Re: almost healed with tianeptine (stablon)

January 28, 2008

How long were you on risperdal for and what was the

exact dose you were on...Also this is good news i read

about the drug just now overlooking it before... it

seems to do the exact opposite of risperdal...It

regulates the HPA and fixes glutamate which risperdal

f*ks up completely...also changes the serotonin which

could be good or bad for just pssd

sufferers...Hopefully you continue to improve i'm

looking forward to hearing more from you...Also did

your doc prescribe this off-label b/c it says not

prescribed in the US....how did you get it unless you

aren't in the states....

all the best nuretronics!!!

What I like best from here

http://www.tianeptine.com/

" Sustained use of tianeptine tends to " normalise " the

hypothalamic-pituitary-adrenal (HPA) system. "

" Prolonged tianeptine use also reduces some forms of

stress-induced apoptosis ( " programmed cell-death " ),

notably in the temporal cortex and dentate gyrus of

the hippocampus. At the molecular level, tianeptine

exerts profound effects on the glutamate system. The

amino acid glutamate serves as the main excitatory

neurotransmitter in the brain. Its excitatory action

is mediated by via multiple receptor subtypes. The

three main subtypes of glutamate-gated ion channel are

kainate, ampa, and N-methyl-D-aspartate (NMDA).

Tianeptine prevents overstimulation of AMPA/kainate

type glutamate receptors in the hippocampus that

regulate Ca2+ entry into the nerve cell; excess Ca2+

entry into nerve cells is toxic. Tianeptine also

modulates the NMDA glutamate receptors. NMDA receptors

for glutamate play a critical role in mediating the

functional and intracellular effects of stress "

--- jonny_man19 wrote:

>

> Dear all,

>

> I started tianeptine on 2nd of january, and

> my health improved gradually over 4 weeks. Now

> I feel almost biologically healed:

> -Normal emotions (before I had no emotions at all)

> -Normal good skin sensitivity (before i was afraid

> to be touched).

> -Gained command again over my body (can do some

> jogging again,

> before I was not able do do and enjoy any

> effort). Before my

> body felt that bad that i thought it was not mine

> anymore and

> my doctor thought that I had schizophrenia

> -I have much less depersonalization, but I still

> feel a bit strange

> -I read again newspapers, books

> -I have no more problems to control my

> urine(before I had a little

> bit problems)

> -can have some nice sex again, and getting an

> orgasm is nice again.

> -have some libido (girls are more erotic than

> trees again)

> -I can sleep again (before I sometimes slept only

> 2hours and

> when taking Risperdal I slept very much)

> -I am not that anxious anymore (no more free

> floating fear)

> -my apetite is normal again

>

> I hope my health will not deteriorate again

>

> I don't know whether I had PSSD, a clinical

> depression or

> schizophrenia, or some mixture of all these

> illnesses, but my

> Illness started one week after I took seroxat (a

> ssri), almost

> two years ago

> I don't even know if most of the people here have

> the same

> illness or if everyone is a different case, as I am

> one of

> the only ones who improved with tianeptine.

>

> Maybe psychology and god played also a big part in

> the improvement,

> first my trust in god improved, then faith in myself

> came back,

> then I did more resarch on the internet, and thought

> that

> tianeptine fitted my symptoms best, and I calculated

> (sorry I was

> a mathematician) that the probability that I had no

> schizophrenia

> but that it was more clinical depression was one in

> five (probability

> my doctor was wrong), and that tianeptine could cure

> that depression

> given that i had a depression was one in five too,

> so the probability

> to get " healed " by tianeptine was on in 25, thus I

> was quite lucky.

> I was also lucky my doctor was very nice and said

> that i could try

> tianeptine

> Regards and thanks for all your support and help

>

> Jean

>

> This group is for support, discussion, or

> educational purposes only. It does not provide

> psychiatric or medical care. All medications and

> supplements should be taken under a doctor's

> supervision.

>

January 28, 2008

Good story. Being an SSRI antagonist, tianeptine might theoretically

be a cure for PSSD IMHO. It may cause its own side effects though.

More people tried this stuff?

>

> Dear all,

>

> I started tianeptine on 2nd of january, and

> my health improved gradually over 4 weeks. Now

> I feel almost biologically healed:

> -Normal emotions (before I had no emotions at all)

> -Normal good skin sensitivity (before i was afraid to be touched).

> -Gained command again over my body (can do some jogging again,

> before I was not able do do and enjoy any effort). Before my

> body felt that bad that i thought it was not mine anymore and

> my doctor thought that I had schizophrenia

> -I have much less depersonalization, but I still feel a bit strange

> -I read again newspapers, books

> -I have no more problems to control my urine(before I had a little

> bit problems)

> -can have some nice sex again, and getting an orgasm is nice again.

> -have some libido (girls are more erotic than trees again)

> -I can sleep again (before I sometimes slept only 2hours and

> when taking Risperdal I slept very much)

> -I am not that anxious anymore (no more free floating fear)

> -my apetite is normal again

>

> I hope my health will not deteriorate again

>

> I don't know whether I had PSSD, a clinical depression or

> schizophrenia, or some mixture of all these illnesses, but my

> Illness started one week after I took seroxat (a ssri), almost

> two years ago

> I don't even know if most of the people here have the same

> illness or if everyone is a different case, as I am one of

> the only ones who improved with tianeptine.

>

> Maybe psychology and god played also a big part in the improvement,

> first my trust in god improved, then faith in myself came back,

> then I did more resarch on the internet, and thought that

> tianeptine fitted my symptoms best, and I calculated (sorry I was

> a mathematician) that the probability that I had no schizophrenia

> but that it was more clinical depression was one in five (probability

> my doctor was wrong), and that tianeptine could cure that depression

> given that i had a depression was one in five too, so the probability

> to get " healed " by tianeptine was on in 25, thus I was quite lucky.

> I was also lucky my doctor was very nice and said that i could try

> tianeptine

> Regards and thanks for all your support and help

>

> Jean

>

January 28, 2008

uptake of serotonin would increase neural nitric oxide synthesis in

the brain.

>

> >

> > Dear all,

> >

> > I started tianeptine on 2nd of january, and

> > my health improved gradually over 4 weeks. Now

> > I feel almost biologically healed:

> > -Normal emotions (before I had no emotions at all)

> > -Normal good skin sensitivity (before i was afraid

> > to be touched).

> > -Gained command again over my body (can do some

> > jogging again,

> > before I was not able do do and enjoy any

> > effort). Before my

> > body felt that bad that i thought it was not mine

> > anymore and

> > my doctor thought that I had schizophrenia

> > -I have much less depersonalization, but I still

> > feel a bit strange

> > -I read again newspapers, books

> > -I have no more problems to control my

> > urine(before I had a little

> > bit problems)

> > -can have some nice sex again, and getting an

> > orgasm is nice again.

> > -have some libido (girls are more erotic than

> > trees again)

> > -I can sleep again (before I sometimes slept only

> > 2hours and

> > when taking Risperdal I slept very much)

> > -I am not that anxious anymore (no more free

> > floating fear)

> > -my apetite is normal again

> >

> > I hope my health will not deteriorate again

> >

> > I don't know whether I had PSSD, a clinical

> > depression or

> > schizophrenia, or some mixture of all these

> > illnesses, but my

> > Illness started one week after I took seroxat (a

> > ssri), almost

> > two years ago

> > I don't even know if most of the people here have

> > the same

> > illness or if everyone is a different case, as I am

> > one of

> > the only ones who improved with tianeptine.

> >

> > Maybe psychology and god played also a big part in

> > the improvement,

> > first my trust in god improved, then faith in myself

> > came back,

> > then I did more resarch on the internet, and thought

> > that

> > tianeptine fitted my symptoms best, and I calculated

> > (sorry I was

> > a mathematician) that the probability that I had no

> > schizophrenia

> > but that it was more clinical depression was one in

> > five (probability

> > my doctor was wrong), and that tianeptine could cure

> > that depression

> > given that i had a depression was one in five too,

> > so the probability

> > to get " healed " by tianeptine was on in 25, thus I

> > was quite lucky.

> > I was also lucky my doctor was very nice and said

> > that i could try

> > tianeptine

> > Regards and thanks for all your support and help

> >

> > Jean

> >

> > This group is for support, discussion, or

> > educational purposes only. It does not provide

> > psychiatric or medical care. All medications and

> > supplements should be taken under a doctor's

> > supervision.

> >

January 28, 2008

it compounds my theory that the ssris have actually depleted

presynaptic serotonin and this is the problem.

> >

> > Dear all,

> >

> > I started tianeptine on 2nd of january, and

> > my health improved gradually over 4 weeks. Now

> > I feel almost biologically healed:

> > -Normal emotions (before I had no emotions at all)

> > -Normal good skin sensitivity (before i was afraid to be

touched).

> > -Gained command again over my body (can do some jogging again,

> > before I was not able do do and enjoy any effort). Before my

> > body felt that bad that i thought it was not mine anymore and

> > my doctor thought that I had schizophrenia

> > -I have much less depersonalization, but I still feel a bit

strange

> > -I read again newspapers, books

> > -I have no more problems to control my urine(before I had a

little

> > bit problems)

> > -can have some nice sex again, and getting an orgasm is nice

again.

> > -have some libido (girls are more erotic than trees again)

> > -I can sleep again (before I sometimes slept only 2hours and

> > when taking Risperdal I slept very much)

> > -I am not that anxious anymore (no more free floating fear)

> > -my apetite is normal again

> >

> > I hope my health will not deteriorate again

> >

> > I don't know whether I had PSSD, a clinical depression or

> > schizophrenia, or some mixture of all these illnesses, but my

> > Illness started one week after I took seroxat (a ssri), almost

> > two years ago

> > I don't even know if most of the people here have the same

> > illness or if everyone is a different case, as I am one of

> > the only ones who improved with tianeptine.

> >

> > Maybe psychology and god played also a big part in the

improvement,

> > first my trust in god improved, then faith in myself came back,

> > then I did more resarch on the internet, and thought that

> > tianeptine fitted my symptoms best, and I calculated (sorry I was

> > a mathematician) that the probability that I had no schizophrenia

> > but that it was more clinical depression was one in five

(probability

> > my doctor was wrong), and that tianeptine could cure that

depression

> > given that i had a depression was one in five too, so the

probability

> > to get " healed " by tianeptine was on in 25, thus I was quite

lucky.

> > I was also lucky my doctor was very nice and said that i could try

> > tianeptine

> > Regards and thanks for all your support and help

> >

> > Jean

> >

>

January 28, 2008

rite, all my research so far points towards ssris depleting serotonin

from neurons, while you were on ssris the uptake of serotonin into

the neurons was inhibited.

you released serotonin into synapsis when you had a thought or

experienced an emotion, this serotonin was prevented form re-entering

the neurons that it came from. mao destroyed the serotonin that the

ssri's prevented from re-entering the neurons. thus creating a

depletion of serotonin in the actual neuron its self for future use.

when serotonin is released from a neuron in a normal processes (with

out ssri) 10% is broken down by mao, the remaining 90% is what should

have been recycled back into the neuron through the serotonin

transporter (sert) that the ssri has blocked. its reasonable to

assume the 10%lost during normal functioning is replaced through

dietary consumption of tryptophan, this 10% at most is what the

ssri's left us with after we discontinued the treatment. (this is not

enough)(would it be fair to say ssris left us with 10% or less

sexuality?)

also its the re-uptake of serotonin into the neuron that synthesizes

neural nitric oxide (this is prevented by the ssri) and we are left

with so little presynaptic serotonin that reuptake of that small

ammount isnt enough to stimulate enough neural nitric oxide, when you

get an erection its neuronal nitric oxide that is released from the

nerves in the penis that then triggers a rush of blood into the penis

that then triggers more nitric oxide to be released from endothelial

cells in the penis. that first neural nitric oxide signal came from

the brain, so its likely that uptake of serotonin had something to do

with this signal, (the ssri disrupted this because it prevents uptake

of serotonin.)

its unclear to me what would happen to a neuron that is depleted of a

neurotransmitter, but i suppose its reasonable to assume it takes on

a smaller structure and possibly grows new connections in an attempt

to compensate.(neuroplasticity)

if its not clear to any of you what im on about with all this, here

it is in simplest terms. the ssri took serotonin out of your brain

and was the instigator of its destruction. this drug puts it back.

another thing thats good about this drug is its half life is only 2.5

hours so it would be easy to start low and build up then ween off.

http://en.wikipedia.org/wiki/Tianeptine

http://www.servier.com/pro/Neurosciences/stablon/stablon_press.asp

http://www.servier.com/pro/Neurosciences/stablon/stablon_video.asp

January 29, 2008

Couple questions.

1) What is an appropriate daily dosage?

2) How can one get a hold of this since it is not available in the US?

Are sites like this one legal or reputable?

http://www.your-onlinepharmacy.com/dr/n/Tianeptine.shtml

Seems shady to me. But even if my doctor was cool with it, I don't

know how or where I'd get it that would be any different.

3) Does anyone know if this would be relevant to the sort of PSSD that

includes low testosterone levels? Did the first poster have low

testosterone levels? Any theories?

>

> rite, all my research so far points towa

rds ssris depleting serotonin

> from neurons, while you were on ssris the uptake of serotonin into

> the neurons was inhibited.

>

> you released serotonin into synapsis when you had a thought or

> experienced an emotion, this serotonin was prevented form re-entering

> the neurons that it came from. mao destroyed the serotonin that the

> ssri's prevented from re-entering the neurons. thus creating a

> depletion of serotonin in the actual neuron its self for future use.

>

> when serotonin is released from a neuron in a normal processes (with

> out ssri) 10% is broken down by mao, the remaining 90% is what should

> have been recycled back into the neuron through the serotonin

> transporter (sert) that the ssri has blocked. its reasonable to

> assume the 10%lost during normal functioning is replaced through

> dietary consumption of tryptophan, this 10% at most is what the

> ssri's left us with after we discontinued the treatment. (this is not

> enough)(would it be fair to say ssris left us with 10% or less

> sexuality?)

>

> also its the re-uptake of serotonin into the neuron that synthesizes

> neural nitric oxide (this is prevented by the ssri) and we are left

> with so little presynaptic serotonin that reuptake of that small

> ammount isnt enough to stimulate enough neural nitric oxide, when you

> get an erection its neuronal nitric oxide that is released from the

> nerves in the penis that then triggers a rush of blood into the penis

> that then triggers more nitric oxide to be released from endothelial

> cells in the penis. that first neural nitric oxide signal came from

> the brain, so its likely that uptake of serotonin had something to do

> with this signal, (the ssri disrupted this because it prevents uptake

> of serotonin.)

>

> its unclear to me what would happen to a neuron that is depleted of a

> neurotransmitter, but i suppose its reasonable to assume it takes on

> a smaller structure and possibly grows new connections in an attempt

> to compensate.(neuroplasticity)

>

> if its not clear to any of you what im on about with all this, here

> it is in simplest terms. the ssri took serotonin out of your brain

> and was the instigator of its destruction. this drug puts it back.

>

> another thing thats good about this drug is its half life is only 2.5

> hours so it would be easy to start low and build up then ween off.

>

> http://en.wikipedia.org/wiki/Tianeptine

>

> http://www.servier.com/pro/Neurosciences/stablon/stablon_press.asp

>

> http://www.servier.com/pro/Neurosciences/stablon/stablon_video.asp

>

January 29, 2008

I'm very intrigued:

Are there any similar drugs that are easier to get a hold of in the USA?

The recent posts on Tianeptine particularly intrigue me because my

anxiety has lowered along with my blunted emotional and sexual

feeling, and increased anxiety is one of the possible side effects of

this drug which basically does the opposite of an SSRI. Hmm...

I'm very interested in any theory of how this drug might or might not

effect my testosterone level (keeping in mind that I am currently

below normal range).

www.Tianeptine.com offers some VERY interesting suggestions:

" Current evidence suggests that tianeptine acts to prevent and even

reverse stress-induced neural damage, promoting both neuronal survival

and synaptic plasticity. Sustained use of tianeptine tends to

" normalise " the hypothalamic-pituitary-adrenal (HPA) system. "

" The side-effect profile of tianeptine is unusually benign. "

" Since melancholic depression is strongly associated with

hypercortisolaemia, which tianeptine reverses, tianeptine may in fact

offer comparable long-term protection against relapse and recurrence. "

" Unlike SSRIs and other " serotonergic " antidepressants, tianeptine

does not dampen libido or sexual performance. Indeed sexual function

may even be enhanced. "

This seems very promising indeed.

Unfortunately, it also costs a freaking fortune and no help from

insurance is in sight...

How'd you pay for it? Do you plan on staying on it indefinitely?

Please let us know what happens if you discontinue treatment.

~

>

> Dear all,

>

> I started tianeptine on 2nd of january, and

> my health improved gradually over 4 weeks. Now

> I feel almost biologically healed:

> -Normal emotions (before I had no emotions at all)

> -Normal good skin sensitivity (before i was afraid to be touched).

> -Gained command again over my body (can do some jogging again,

> before I was not able do do and enjoy any effort). Before my

> body felt that bad that i thought it was not mine anymore and

> my doctor thought that I had schizophrenia

> -I have much less depersonalization, but I still feel a bit strange

> -I read again newspapers, books

> -I have no more problems to control my urine(before I had a little

> bit problems)

> -can have some nice sex again, and getting an orgasm is nice again.

> -have some libido (girls are more erotic than trees again)

> -I can sleep again (before I sometimes slept only 2hours and

> when taking Risperdal I slept very much)

> -I am not that anxious anymore (no more free floating fear)

> -my apetite is normal again

>

> I hope my health will not deteriorate again

>

> I don't know whether I had PSSD, a clinical depression or

> schizophrenia, or some mixture of all these illnesses, but my

> Illness started one week after I took seroxat (a ssri), almost

> two years ago

> I don't even know if most of the people here have the same

> illness or if everyone is a different case, as I am one of

> the only ones who improved with tianeptine.

>

> Maybe psychology and god played also a big part in the improvement,

> first my trust in god improved, then faith in myself came back,

> then I did more resarch on the internet, and thought that

> tianeptine fitted my symptoms best, and I calculated (sorry I was

> a mathematician) that the probability that I had no schizophrenia

> but that it was more clinical depression was one in five (probability

> my doctor was wrong), and that tianeptine could cure that depression

> given that i had a depression was one in five too, so the probability

> to get " healed " by tianeptine was on in 25, thus I was quite lucky.

> I was also lucky my doctor was very nice and said that i could try

> tianeptine

> Regards and thanks for all your support and help

>

> Jean

>

January 29, 2008

nemo.shark, this kind of post should be in a diferent thread.

This theory doesn't even apply to this guys case because he was on

risperdal for 16 months and that would have caused more sexual

dysfunction than the SSRI.

>

> rite, all my research so far points towards ssris depleting serotonin