RESEARCH - Intraarticular drug delivery in osteoarthritis

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Adv Drug Deliv Rev. 2006 May 20;58(2):226-42. Epub 2006 Feb 23.

Intraarticular drug delivery in osteoarthritis.

Bone and Cartilage Research, Novartis Institutes for BioMedical Research,

Novartis Pharma AG, WKL-125.13.59, CH-4002 Basel, Switzerland.

nicole.gerwin@...

Osteoarthritis (OA) is a primarily non-inflammatory, degenerative joint

disease characterized by progressive loss of articular cartilage,

subchondral bone sclerosis, osteophyte formation, changes in the synovial

membrane, and an increased volume of synovial fluid with reduced viscosity

and hence changed lubrication properties. As OA is the most common type of

arthritis and a leading cause of disability, there is a largely unmet

medical need for disease-modifying and symptomatic treatment. Due to the

localized nature of the disease, intraarticular (IA) drug injection is an

attractive treatment approach for OA. The various glucocorticoid and

hyaluronic acid (HA) formulations, which are currently available on the

market for IA treatment, provide only short-term pain relief or/and often do

not provide adequate pain relief. The available oral drugs for symptomatic

treatment also have shortcomings, most notably side effects. Therefore,

there is still a large unmet need for novel OA drugs, which provide

effective long-term pain relief and/or have disease-modifying properties. To

achieve long-term drug exposure, different established formulations such as

suspensions and hydrogels, and also novel approaches such as lipid based

formulations and nano- or microparticles are currently in development. The

development of novel drugs in combination with new formulations for IA

treatment of OA, represents a promising approach in this challenging area of

research.

PMID: 16574267

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrieve & dopt=Abstra\

ctPlus & list_uids=16574267

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