Guest guest Posted January 16, 2008 Report Share Posted January 16, 2008 I have seen the site before. Your theories on what causes pssd are all very speculative. The experiment on rats from the 1970's that invisaged pssd showed that pssd causes desensitization of the dopamine receptors. I assumed that what happened was that the dopamine receptors did not work as well any more. Most people with pssd have poor dopaimine, for instance some have signs of restless leg syndrome. There is no proof that people with pssd have low protaclin. Protaclin is not only released by orgasm, it is also released by other things. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 16, 2008 Report Share Posted January 16, 2008 can you put a link up for the research done on rats? ive wanted to read this for some time, is the same research that found changes in gene expression? id like to read that also if you have a link. thanks! if what you said is correct, then treatments for parkinson's is a possibility maybe. are sexual problems common in parkinson's? can the dopamine receptor be re-sensitised maybe? i would have thought that low dopamine would increase dopamine receptor sensitivity or density? if it doesn't ldopa may resencitise them. or even surges of prolactin. > > I have seen the site before. Your theories on what causes pssd are all > very speculative. The experiment on rats from the 1970's that invisaged > pssd showed that pssd causes desensitization of the dopamine receptors. > I assumed that what happened was that the dopamine receptors did not > work as well any more. > > Most people with pssd have poor dopaimine, for instance some have signs > of restless leg syndrome. There is no proof that people with pssd have > low protaclin. Protaclin is not only released by orgasm, it is also > released by other things. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 16, 2008 Report Share Posted January 16, 2008 Drugs that may increase prolactin include phenothiazines, oral contraceptives, opiates, histamine antagonists, monoamine oxidase inhibitors (MAO inhibitors), estrogen, and antihistamines. Drugs that can decrease values include levodopa and dopamine. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 16, 2008 Report Share Posted January 16, 2008 vornan seen an improvement after being on Moclobemide this also raises prolactin as well as other things, but the raised prolactin could have had a role to play in the positive effects he had on it. he said it was when he started to tapper off the drug that he seen the most interesting effects. temporary elevation of prolactin could have had a role to play in this effect, especially when dopamine started to function properly after coming off it. if you think about it this drug also raises all the other monoamine transmitters, but its dopamine that would have had the least amount of elevation or activity due to the drugs effects on prolactin. http://en.wikipedia.org/wiki/Moclobemide > > > Drugs that may increase prolactin include phenothiazines, oral > contraceptives, opiates, histamine antagonists, monoamine oxidase > inhibitors (MAO inhibitors), estrogen, and antihistamines. Drugs that > can decrease values include levodopa and dopamine. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 17, 2008 Report Share Posted January 17, 2008 Actually, MDMA may have a similar effect. it raises prolactin for some time and also stops the reuptake of serotonin, dopamine, and adrenaline. But I always assumed that we always had high prolactin due to poor dopamine neurotransmission? At the moment I am taking bupropion plus 5HTP. I am hoping that this will normalise my serotonin receptors and also at the same time improve dopamine and adrenaline. After that I am going to try doing loads of swimming because I am pretty certain that every time I have had improvements it has been due partly to endorphins. However, even as my libido raises with the bupropion I still have a low sex drive and don't get regular erections. Therefe I am getting my testosterone checked as well. I am also going to switch from a bupropion to an agonist asap, because I think they are more healthy in the long run. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 17, 2008 Report Share Posted January 17, 2008 I have posted up the whole experiment as it is not that long, but you can see it yourself on the link from the wikipedia site. Department of Anatomy, Radboud University Nijmegen Medical Centre, (Intern Mail Nr. 230) Postbus 9101 6500 HB, Nijmegen, The Netherlands. t.dejong@... Selective Serotonin Reuptake Inhibitors (SSRIs) are designed to treat adults, but are increasingly prescribed for adolescents. SSRIs might cause permanent changes in serotonin-related behavior in adolescents, since their serotonergic system is still developing. Male Wistar rats were treated with paroxetine (15 mg/kg p.o.) or fluvoxamine (30 mg/kg p.o.) throughout adolescence. After a washout period their behavior in the elevated plus-maze, prepulse inhibition test, Forced swimming test and elevated T-maze were studied. In addition, the effects of the 5-HT(1A) receptor agonist 8-OH-DPAT on sexual behavior and lower lip retraction were measured. Paroxetine mildly inhibited weight gain during treatment. Both SSRIs caused a reduction in ejaculation frequency and in time spent on the open arm of the elevated plus-maze in adult rats. Fluvoxamine slightly increased avoidance latency in the elevated T-maze compared to paroxetine. No differences between the groups were found in the other tests. Apparently, chronic treatment with SSRIs during adolescence may cause mild changes in adult behavior. Hm, not much help there, although it does mention the 5-HT receptor. It is possible to improve that recpetor using an agonist. Yes you are right about the Parkinson's disease drugs, they are commonly used to raise libido in people suffering from PSSD. Most people who have taken dopamine agonsits or reuptake inhibitors (including me) say that they notice a return of sexual interest. But it is a matter of finding the right one, and hitting the right combination of receptors. As far as I am aware, what agonsits do is essentially to " trigger " certain receptors. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 17, 2008 Report Share Posted January 17, 2008 I found something on dopamine agonists from a guy called biker, but he posted this and then I dont think he ever posted again. Ritalin is much more affordable than dostinex I think, and probably far more tollerable: beezly, unfortunately I can not access Yahoo groups from work because Yahoo groups and e-mail are blocked by the server in our head office. In addition to that I have to travel a lot in my job. I rarely find the time and energy to post when I'm home. I work long hours, go to the gym and that pretty much sums up my day. I do want to keep you all updated and I will do that as promised. My good experience with Ritalin (Concerta) was an incredible one. And yes, the stuff still works. As I stopped taking it the effect lasted for five days. On the sixth day my libido started diminishing slowly, and my skin sensitivity got worse. Then I had to go on a business trip to Germany and there I took Concerta again for four days. For the first three days I felt no different. My libido was almost non- existant again and genital sensitivity was pretty poor. But as the fourth day on Ritalin had gone by it happened again. Boom. Libido and skin sensitivity both came back. And this time the effect was even stronger than before! I caught a bad stomach flu in Germany and was actually hospitalized as I got back home to Finland. I lost over 12 pounds inside 48 hours. Despite my terrible nausea, cramps and headache I felt horny. Now that is a good sign, isn't it? =) It's been over ten days since my last dose of Concerta and I'm still feeling good. Libido is not quite as strong as it was right after taking the drug, but I have a feeling things get better and better every time I try the stimulants. The effect stays on longer and longer and I feel I'm slowly getting better for good. I'll take another cycle of Concerta or Adderall (if I can get my hands on it) next week and hopefully things will keep improving. I would not feel ashamed for telling you bad news. I've had to do that too in the past. I do not feel shame because of pssd. And I do not feel shame for fighting it and reporting the news. Good or bad. Biker Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 17, 2008 Report Share Posted January 17, 2008 yep i think agoinst makes a receptor more receptive. i suppose when they say " after a wash out phase " they mean a period of time without the administration of the drug. but they dont say how long this wash out phase was or how long the observations went on for and theres no mention of physical changes in the brain. (at least i dont think there is) > > I have posted up the whole experiment as it is not that long, but you > can see it yourself on the link from the wikipedia site. > > Department of Anatomy, Radboud University Nijmegen Medical Centre, > (Intern Mail Nr. 230) Postbus 9101 6500 HB, Nijmegen, The > Netherlands. t.dejong@... > > Selective Serotonin Reuptake Inhibitors (SSRIs) are designed to treat > adults, but are increasingly prescribed for adolescents. SSRIs might > cause permanent changes in serotonin-related behavior in adolescents, > since their serotonergic system is still developing. Male Wistar rats > were treated with paroxetine (15 mg/kg p.o.) or fluvoxamine (30 mg/kg > p.o.) throughout adolescence. After a washout period their behavior > in the elevated plus-maze, prepulse inhibition test, Forced swimming > test and elevated T-maze were studied. In addition, the effects of > the 5-HT(1A) receptor agonist 8-OH-DPAT on sexual behavior and lower > lip retraction were measured. Paroxetine mildly inhibited weight gain > during treatment. Both SSRIs caused a reduction in ejaculation > frequency and in time spent on the open arm of the elevated plus- maze > in adult rats. Fluvoxamine slightly increased avoidance latency in > the elevated T-maze compared to paroxetine. No differences between > the groups were found in the other tests. Apparently, chronic > treatment with SSRIs during adolescence may cause mild changes in > adult behavior. > > Hm, not much help there, although it does mention the 5-HT receptor. > It is possible to improve that recpetor using an agonist. > > Yes you are right about the Parkinson's disease drugs, they are > commonly used to raise libido in people suffering from PSSD. Most > people who have taken dopamine agonsits or reuptake inhibitors > (including me) say that they notice a return of sexual interest. But > it is a matter of finding the right one, and hitting the right > combination of receptors. As far as I am aware, what agonsits do is > essentially to " trigger " certain receptors. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 17, 2008 Report Share Posted January 17, 2008 i believe Ritalin is a cns stimulant, so is caffeine (i think) ive had a couple of strange returns in libido after doing a few coffee enemas. also i read some time ago that co-enzyme q10 taken at a high dose gives similar cns stimulation as Ritalin. im not sure if these things are dopamine agonists though. > > I found something on dopamine agonists from a guy called biker, but > he posted this and then I dont think he ever posted again. Ritalin is > much more affordable than dostinex I think, and probably far more > tollerable: > > beezly, unfortunately I can not access Yahoo groups from work > because Yahoo groups and e-mail are blocked by the server in our head > office. In addition to that I have to travel a lot in my job. I rarely > find the time and energy to post when I'm home. I work long hours, go > to the gym and that pretty much sums up my day. I do want to keep you > all updated and I will do that as promised. > > My good experience with Ritalin (Concerta) was an incredible one. And > yes, the stuff still works. As I stopped taking it the effect lasted > for five days. On the sixth day my libido started diminishing slowly, > and my skin sensitivity got worse. Then I had to go on a business trip > to Germany and there I took Concerta again for four days. > > For the first three days I felt no different. My libido was almost > non- > existant again and genital sensitivity was pretty poor. But as the > fourth day on Ritalin had gone by it happened again. Boom. Libido and > skin sensitivity both came back. And this time the effect was even > stronger than before! > > I caught a bad stomach flu in Germany and was actually hospitalized as > I got back home to Finland. I lost over 12 pounds inside 48 hours. > Despite my terrible nausea, cramps and headache I felt horny. Now that > is a good sign, isn't it? =) > > It's been over ten days since my last dose of Concerta and I'm still > feeling good. Libido is not quite as strong as it was right after > taking the drug, but I have a feeling things get better and better > every time I try the stimulants. The effect stays on longer and longer > and I feel I'm slowly getting better for good. > > I'll take another cycle of Concerta or Adderall (if I can get my hands > on it) next week and hopefully things will keep improving. > > I would not feel ashamed for telling you bad news. I've had to do that > too in the past. I do not feel shame because of pssd. And I do not > feel > shame for fighting it and reporting the news. Good or bad. > > > Biker > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 17, 2008 Report Share Posted January 17, 2008 i dont think the problem lies with low dopamine but probably more to do with dopamine receptors or dopamine releace. a thing that i keep finding strange is, this hole pssd thing gets me down but i feel emotionally and physically the best ive ever felt. i sometimes choose to think about pssd until it really gets me literally depressed (or unavoidably start to think about it until it depresses me) but even when im like this i still sort of feel good or good ov sorts kind ov weired thing to describe! but this is what ive noticed when i choose or just get dragged down by depressive thoughts, after a period of time thinking depressive thoughts my libido or at least the response to erotic thoughts seem to have more of an emotional and physical response. its like making myself feel bad makes it easier to think positively about sex and realise its an enjoyable thing, its only when im feeling just fine when the erotic thoughts seem to be something im just not interested in. i know this sounds weired and you probably dont understand what im on about, its hard to put into words. > > Actually, MDMA may have a similar effect. it raises prolactin for some > time and also stops the reuptake of serotonin, dopamine, and > adrenaline. But I always assumed that we always had high prolactin due > to poor dopamine neurotransmission? > > At the moment I am taking bupropion plus 5HTP. I am hoping that this > will normalise my serotonin receptors and also at the same time improve > dopamine and adrenaline. After that I am going to try doing loads of > swimming because I am pretty certain that every time I have had > improvements it has been due partly to endorphins. > > However, even as my libido raises with the bupropion I still have a low > sex drive and don't get regular erections. Therefe I am getting my > testosterone checked as well. > > I am also going to switch from a bupropion to an agonist asap, because > I think they are more healthy in the long run. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 17, 2008 Report Share Posted January 17, 2008 Have you not tried a dopamine agonist or anything like that yet? I would recomend you do. If you are feeling depressed, might want to try some 5HTP. I dunno about dopamine release tbh. Is there anyone in the group with more knowledge of this kind of thing? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 17, 2008 Report Share Posted January 17, 2008 I remember messages reporting mental clarity of the kind you mention never happened before. So including myself i can say we perfectly understand you. > > > > Actually, MDMA may have a similar effect. it raises prolactin for > some > > time and also stops the reuptake of serotonin, dopamine, and > > adrenaline. But I always assumed that we always had high prolactin > due > > to poor dopamine neurotransmission? > > > > At the moment I am taking bupropion plus 5HTP. I am hoping that > this > > will normalise my serotonin receptors and also at the same time > improve > > dopamine and adrenaline. After that I am going to try doing loads > of > > swimming because I am pretty certain that every time I have had > > improvements it has been due partly to endorphins. > > > > However, even as my libido raises with the bupropion I still have a > low > > sex drive and don't get regular erections. Therefe I am getting my > > testosterone checked as well. > > > > I am also going to switch from a bupropion to an agonist asap, > because > > I think they are more healthy in the long run. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 18, 2008 Report Share Posted January 18, 2008 im not depressed, thinking about pssd makes gets me down but periods of feeling down makes it much easier to initiate a sexual response to any thing. its weired. i think serotonin transmission is what is getting in the way of normal sexual responses. feeling down or depressed its much easier to switch on to sex than feeling just fine or better than just fine. i dont think its dopamine that's two low i think its serotonin or serotonin activity that's two high for a dopamine response to break through. > > Have you not tried a dopamine agonist or anything like that yet? I > would recomend you do. If you are feeling depressed, might want to try > some 5HTP. > > I dunno about dopamine release tbh. Is there anyone in the group with > more knowledge of this kind of thing? > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 18, 2008 Report Share Posted January 18, 2008 i feel permanently hard wired for happy feelings but i can still think about the worce things in the world that make me sad & depressed until it gets me down or depressed of sorts, but still sometimes im really feeling sorry for myself about pssd and other things in general that im missing out on at this time in my life. while this is happening though its hard to feel emotionally sad, even while im thinking about the worce things ever in the world i find a smile going onto my face its fucking crazy! i feel like crying when this happens but still i cant. one thing is for sure though if all those shootings in the u.s over recent years had any thing to do with this kind of experience, i can fully understand why someone might be that pissed of with the world to do it! > > > > > > Actually, MDMA may have a similar effect. it raises prolactin for > > some > > > time and also stops the reuptake of serotonin, dopamine, and > > > adrenaline. But I always assumed that we always had high prolactin > > due > > > to poor dopamine neurotransmission? > > > > > > At the moment I am taking bupropion plus 5HTP. I am hoping that > > this > > > will normalise my serotonin receptors and also at the same time > > improve > > > dopamine and adrenaline. After that I am going to try doing loads > > of > > > swimming because I am pretty certain that every time I have had > > > improvements it has been due partly to endorphins. > > > > > > However, even as my libido raises with the bupropion I still have a > > low > > > sex drive and don't get regular erections. Therefe I am getting my > > > testosterone checked as well. > > > > > > I am also going to switch from a bupropion to an agonist asap, > > because > > > I think they are more healthy in the long run. > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 18, 2008 Report Share Posted January 18, 2008 This sounds wonderful. I assume you are male. Do you think that Ritalin will work for females? I have been on SSRI,s for years and miss having orgasms. Prior to SSRI I was very capable of orgasm, it was always intense. I could only have one per night or day but it was very intense knock you out asleep good! Another strange thing. I have read posts from males about sleep and orgasm. I sometimes have very intense dreams where I am going into a fantastic orgasm [like the good old days] and suddenly I wake up wet and unfulfilled. Damn it. It is like orgasm is not possible . I think serotonin or dopamine are conflicted with sleep and being awake. very weird how I am going into a big O and then I wake up unfulfilled and very upset. JD Re: dopamine prolactin orgasm I found something on dopamine agonists from a guy called biker, but he posted this and then I dont think he ever posted again. Ritalin is much more affordable than dostinex I think, and probably far more tollerable:beezly, unfortunately I can not access Yahoo groups from workbecause Yahoo groups and e-mail are blocked by the server in our headoffice. In addition to that I have to travel a lot in my job. I rarelyfind the time and energy to post when I'm home. I work long hours, goto the gym and that pretty much sums up my day. I do want to keep youall updated and I will do that as promised.My good experience with Ritalin (Concerta) was an incredible one. Andyes, the stuff still works. As I stopped taking it the effect lastedfor five days. On the sixth day my libido started diminishing slowly,and my skin sensitivity got worse. Then I had to go on a business tripto Germany and there I took Concerta again for four days.For the first three days I felt no different. My libido was almost non-existant again and genital sensitivity was pretty poor. But as thefourth day on Ritalin had gone by it happened again. Boom. Libido andskin sensitivity both came back. And this time the effect was evenstronger than before!I caught a bad stomach flu in Germany and was actually hospitalized asI got back home to Finland. I lost over 12 pounds inside 48 hours.Despite my terrible nausea, cramps and headache I felt horny. Now thatis a good sign, isn't it? =)It's been over ten days since my last dose of Concerta and I'm stillfeeling good. Libido is not quite as strong as it was right aftertaking the drug, but I have a feeling things get better and betterevery time I try the stimulants. The effect stays on longer and longerand I feel I'm slowly getting better for good.I'll take another cycle of Concerta or Adderall (if I can get my handson it) next week and hopefully things will keep improving.I would not feel ashamed for telling you bad news. I've had to do thattoo in the past. I do not feel shame because of pssd. And I do not feelshame for fighting it and reporting the news. Good or bad.Biker Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 19, 2008 Report Share Posted January 19, 2008 that was happening to me for a while id wake up in half like dream state with an erection having an erotic dream. when i fully woke up the erection would just drop and there was no way i could keep it up, after time its started to over lap and im able to keep the feelings in the dream with me for longer after im fully awake. note that when your in rem sleep phase (dreaming phase of sleep) monoamine neurotransmitters are shut down and yes thats dopamine and serotonin. > > > This sounds wonderful. I assume you are male. Do you think that Ritalin will work for females? > I have been on SSRI,s for years and miss having orgasms. Prior to SSRI I was very capable of orgasm, it was always intense. I could only have one per night or day but it was very intense knock you out asleep good! > Another strange thing. I have read posts from males about sleep and orgasm. I sometimes have very intense dreams where I am going into a fantastic orgasm [like the good old days] > and suddenly I wake up wet and unfulfilled. Damn it. It is like orgasm is not possible . I think serotonin or dopamine are conflicted with sleep and being awake. very weird how I am going into a big O and then I wake up unfulfilled and very upset. > JD > Re: dopamine prolactin orgasm > > > I found something on dopamine agonists from a guy called biker, but > he posted this and then I dont think he ever posted again. Ritalin is > much more affordable than dostinex I think, and probably far more > tollerable: > > beezly, unfortunately I can not access Yahoo groups from work > because Yahoo groups and e-mail are blocked by the server in our head > office. In addition to that I have to travel a lot in my job. I rarely > find the time and energy to post when I'm home. I work long hours, go > to the gym and that pretty much sums up my day. I do want to keep you > all updated and I will do that as promised. > > My good experience with Ritalin (Concerta) was an incredible one. And > yes, the stuff still works. As I stopped taking it the effect lasted > for five days. On the sixth day my libido started diminishing slowly, > and my skin sensitivity got worse. Then I had to go on a business trip > to Germany and there I took Concerta again for four days. > > For the first three days I felt no different. My libido was almost > non- > existant again and genital sensitivity was pretty poor. But as the > fourth day on Ritalin had gone by it happened again. Boom. Libido and > skin sensitivity both came back. And this time the effect was even > stronger than before! > > I caught a bad stomach flu in Germany and was actually hospitalized as > I got back home to Finland. I lost over 12 pounds inside 48 hours. > Despite my terrible nausea, cramps and headache I felt horny. Now that > is a good sign, isn't it? =) > > It's been over ten days since my last dose of Concerta and I'm still > feeling good. Libido is not quite as strong as it was right after > taking the drug, but I have a feeling things get better and better > every time I try the stimulants. The effect stays on longer and longer > and I feel I'm slowly getting better for good. > > I'll take another cycle of Concerta or Adderall (if I can get my hands > on it) next week and hopefully things will keep improving. > > I would not feel ashamed for telling you bad news. I've had to do that > too in the past. I do not feel shame because of pssd. And I do not > feel > shame for fighting it and reporting the news. Good or bad. > > Biker > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 19, 2008 Report Share Posted January 19, 2008 What is the experience of using Ritalin / low-dose CNS for PSSD? Is there anybody who has gotten got improvements on a more permanent basis from it - is it worth a try? Ritalin/Concerta et al can also address some of the mood/cognition-related issues that SSRI:s are supposed to address, so if they alleviate PSSD it could be a gain on two fronts. Nemo quoted from what I believe is an old post from Biker: // UIf "My good experience with Ritalin (Concerta) was an incredible one. And yes, the stuff still works. As I stopped taking it the effect lastedfor five days. On the sixth day my libido started diminishing slowly, and my skin sensitivity got worse. Then I had to go on a business trip to Germany and there I took Concerta again for four days.For the first three days I felt no different. My libido was almost nonexistant again and genital sensitivity was pretty poor. But as thefourth day on Ritalin had gone by it happened again. Boom. Libido and skin sensitivity both came back. And this time the effect was evenstronger than before!..... It's been over ten days since my last dose of Concerta and I'm stillfeeling good. Libido is not quite as strong as it was right aftertaking the drug, but I have a feeling things get better and betterevery time I try the stimulants. The effect stays on longer and longer and I feel I'm slowly getting better for good"Biker And an old post from Vornan that I found: "I think adderall is worth a try, but that's not the right way to do it. You should take it in two-week on/off cycles and not go above 5mg/day. When you take a stimulant like adderall or ritalin there are basically two ways your brain can react to it, and they are kind of opposites. The first way is desensitization and this usually happens when you take high doses (like 30 mg/day) for long periods of time. It's probably caused by downregulation of receptors. That's why some people who take ritalin or adderall initially get a huge increase in libido but inevitably lose it after some time. The second, and opposite, way is called sensitization and it usually happens when you take *low* doses of a stimulant intermittently. Somehow an opposite kind of adpatation occurs and the brain actually becomes more sensitive to the drug so you need to take less and less to get good results.This is what I recommended to Biker and with each cycle he seems to be getting better and better. I think he will fully recover in time....... Of course, this program should only be done with a doctor's prescription" Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 20, 2008 Report Share Posted January 20, 2008 Vornan I don't thinK I have spoken to you at all yet. I have had similar experiences with bupropion. I have also tried speed, MDMA, monafinil, and sleep deprivation seems to have a smilar response. I agree with all of thsi stuff about needing to take it on/off. I think the resoning makes sense too. I hope this is not too off topic, but I find even though my libido raises a lot, I still cannot get spontanious erections at all, and I am still physically unable to cry (maybe a bit more so). This is strange because I am also taking 5HTP. When I was suffering from sleep deprivation I got completely better for a few days, which I had assumed to be the strange effects of dopamine/serotonin on the brain. But do you think its possible that ssris also effect the muscarinic neurotransmittors? For instance they could do so indirectly by inhibiting REM sleep? If so, should we consider mixing a dopamine agonsit with a muscarinic agonist? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 20, 2008 Report Share Posted January 20, 2008 Oh sorry, that wasn't a post from vornan, just a copy! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 13, 2008 Report Share Posted February 13, 2008 I've been going back to this post. I believe adderal is probably worth a try if things like bupropion and dostinex do not work for you. I'm pretty certain that when I started getting better for a couple of weeks (whilst comoing down from MDMA) I was also eating loads of dark chocolate (88%). I didn't see the connection back then, but surely this must have benefits also? Nemo and I have both been lookign into the problems caused by Nitric Oxide. I now believe that the main problem is that nitric oxide is not sent to the genitals in high enough levles due to problems with Phenethylamines, dopamine and norepinphrine. I think it is most likely to be a distubbance in these chemicals/ neurotransmittors that induces an inability to cry, inability to love, loss of emotions, poor concentration. I think it is unliklely to be a disturbance in serotonin that produces an inability to cry. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 14, 2008 Report Share Posted February 14, 2008 I have seen this theory before. I believe it is wrong. Yes I realised today that dark chocolate contains large amounts of tryptophan. First of all, I think that people with pssd probably don't have raised serotonin levles. i think it proably normalises over time. Secondly the only 2 times I got natural erections were during sleep deprivation and also whilst taking MDMA. This seems to suggest that you can raise serotonin and still get natural erections. I think if you were not producing enough nitric oxide synthase, your heart would be slowing down, your arteries would be hardening etc. I still think you shoudl look at my last post about the nitric oxide signalling. > > > > I've been going back to this post. I believe adderal is probably > worth > > a try if things like bupropion and dostinex do not work for you. > > > > I'm pretty certain that when I started getting better for a couple > of > > weeks (whilst comoing down from MDMA) I was also eating loads of > dark > > chocolate (88%). I didn't see the connection back then, but surely > this > > must have benefits also? > > > > Nemo and I have both been lookign into the problems caused by > Nitric > > Oxide. I now believe that the main problem is that nitric oxide is > not > > sent to the genitals in high enough levles due to problems with > > Phenethylamines, dopamine and norepinphrine. > > > > I think it is most likely to be a distubbance in these chemicals/ > > neurotransmittors that induces an inability to cry, inability to > love, > > loss of emotions, poor concentration. I think it is unliklely to be > a > > disturbance in serotonin that produces an inability to cry. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2008 Report Share Posted February 15, 2008 do you think that if your not producing enough *nural* nitric oxide sythesis your heart would slow down ect? put a link up to the post you want me to read? > > > > > > I've been going back to this post. I believe adderal is probably > > worth > > > a try if things like bupropion and dostinex do not work for you. > > > > > > I'm pretty certain that when I started getting better for a > couple > > of > > > weeks (whilst comoing down from MDMA) I was also eating loads of > > dark > > > chocolate (88%). I didn't see the connection back then, but > surely > > this > > > must have benefits also? > > > > > > Nemo and I have both been lookign into the problems caused by > > Nitric > > > Oxide. I now believe that the main problem is that nitric oxide > is > > not > > > sent to the genitals in high enough levles due to problems with > > > Phenethylamines, dopamine and norepinphrine. > > > > > > I think it is most likely to be a distubbance in these chemicals/ > > > neurotransmittors that induces an inability to cry, inability to > > love, > > > loss of emotions, poor concentration. I think it is unliklely to > be > > a > > > disturbance in serotonin that produces an inability to cry. > > > > > > Quote Link to comment Share on other sites More sharing options...
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