Re: gilberts syndrome

[Guest guest]

after gaining a bit more of an understanding into gilberts syndrome

it seems that about 1 in 100 people have it.

there seems to be about 10-15 people on here that post regular and 3

people out of those regulars have gilberts syndrome.

also some people seem to be having positive results in regard to pssd

after undergoing some sort of detox, or taking something that effects

phase two detoxification in a positive way (sam'e being one of them)

or slows down phase one.(grapefruit juice)

there seems to be different stages of gilberts syndrome with

different degrees of severity, linked to surtain genes & mutations of

genes which effect liver metabolism & detoxification.

possibly some of these mutations are present in other people but they

do not effect blood levels of bilirubin enough for it to be picked up

in a routine blood test, so these people have some form of impaired

metabolism/detoxification that does not effect the detectable

indicator of gilberts syndrome.

one thing is for sure though all of us on here had a bad reaction to

these drugs and it seems more prevalent in those with gilberts

syndrome.

im thinking is it possible for some of these gene mutations to be

present in all of us on here? and this is the similarity between all

of us that are experiencing pssd......

one of the enzymes deficient in gilberts syndrome is the one

responsible for elimination of estrogen's! (this would explain my

high estrogen to testosterone ratio)

bacically we will become more feminised as we age and more so when

this enzyme is compromised by taking drugs or consuming chemicals

that require it for elimination.

one interesting thing i came across was a connection with gilberts

syndrome and hypothyroidism (low thyroid) it seems that border line

or full blown hypothyroidism is more prevalent in people with

gilberts syndrome and most people on here seem to have low thyroid

symptoms!

it seems there's a protein that attaches to bilirubin that is also

responsible for the transportation of thyroid hormone, so high

bilirubin could leave less of this protein available for the

transportation of thyroid hormone.

apparently caffeine can detach the bilirubin from this protein and

possibly free the protein up for better thyroid distribution. (this

is a theory by the guy that created gilberts syndrome.com) but this

could also explain why i temporarily got my libido back the night i

did a really strong coffee enema.

it seems there's a few things you can take to improve gilberts

syndrome or phase two detoxification pathways.

Phenobarbital is one thing but it kind of scares me as its a powerful

drug, but on the gilberts syndrome web sight there's a few people

that say it works for them, they take it for a couple of weeks and

they say its effects clear there systems for about six months before

they need it again.

http://en.wikipedia.org/wiki/Phenobarbital

another thing is u.v light sunlight breaks down bilirubin so the

lesser amount would free up the protein that transports thyroid

hormone and possibly bring back some sex drive due to a higher

thyroid level. (just a theory but could this explain the consistently

higher amount of pssd posts 3 years on the run during the winter

months?)

http://health.groups.yahoo.com/group/SSRIsex/

im looking into supplements for gilberts syndrome at the moment and

will post the ones i find beneficial here.

but one thing i did come across is b3 (niacin) apparently it

shouldn't be taken by people with gilberts syndrome as it does

increase serum levels of bilirubin shortly after consumption, i found

this interesting because i know some people on here have been taking

it in high amounts accompanying it with infra red saunas.

i know at least one of you that's done this has had a dramatic

improvement from pssd (bicker, i think) and he noticed that his pssd

got worce while doing this and his improvement came on later.

high dose b3 would have increased his bilirubin levels even if he

didn't have gilberts syndrome, but even though b3 increases bilirubin

levels it still could be this increase and expulsion of bilirubin

that contributed to his improvments.

personally speaking, i think its possible for most if not all of us

on here to have some or one of the gene's or mutations in gene's

associated with gilberts syndrome and its this that's effected the

ssris metabolism.

>

> seen as though some people on here ive spoke to have gilberts

syndrome

> as well as my self, i thought id start this post to discuss it and

put

> this link up with comprehensive information about the condition.

>

> http://www.gilbertssyndrome.com/

>

[Guest guest]

Nemo,

I just looked into gilberts syndrome. Although i

have not been diagnosed with it,i can say that i

suffer from most of the symptoms, with the exception

of yellow eyes and skin. Not that this means

anything--it could be CFS, fibromyalgia, tertiary lyme

disease, etc etc--many symptoms can be attributed to

several other diseases/syndromes. I went to your link

for gilberts syndrome and found all of the symptoms

such as body aches, anxiety, heart palpitations, etc

etc--then i went to wikipedia and looked, and NONE of

those symptoms are listed. What the heck is up with

that???

--- " nemo.shark " wrote:

> after gaining a bit more of an understanding into

> gilberts syndrome

> it seems that about 1 in 100 people have it.

>

> there seems to be about 10-15 people on here that

> post regular and 3

> people out of those regulars have gilberts syndrome.

>

> also some people seem to be having positive results

> in regard to pssd

> after undergoing some sort of detox, or taking

> something that effects

> phase two detoxification in a positive way (sam'e

> being one of them)

> or slows down phase one.(grapefruit juice)

>

> there seems to be different stages of gilberts

> syndrome with

> different degrees of severity, linked to surtain

> genes & mutations of

> genes which effect liver metabolism &

> detoxification.

>

> possibly some of these mutations are present in

> other people but they

> do not effect blood levels of bilirubin enough for

> it to be picked up

> in a routine blood test, so these people have some

> form of impaired

> metabolism/detoxification that does not effect the

> detectable

> indicator of gilberts syndrome.

>

> one thing is for sure though all of us on here had a

> bad reaction to

> these drugs and it seems more prevalent in those

> with gilberts

> syndrome.

>

> im thinking is it possible for some of these gene

> mutations to be

> present in all of us on here? and this is the

> similarity between all

> of us that are experiencing pssd......

>

> one of the enzymes deficient in gilberts syndrome is

> the one

> responsible for elimination of estrogen's! (this

> would explain my

> high estrogen to testosterone ratio)

>

> bacically we will become more feminised as we age

> and more so when

> this enzyme is compromised by taking drugs or

> consuming chemicals

> that require it for elimination.

>

> one interesting thing i came across was a connection

> with gilberts

> syndrome and hypothyroidism (low thyroid) it seems

> that border line

> or full blown hypothyroidism is more prevalent in

> people with

> gilberts syndrome and most people on here seem to

> have low thyroid

> symptoms!

>

> it seems there's a protein that attaches to

> bilirubin that is also

> responsible for the transportation of thyroid

> hormone, so high

> bilirubin could leave less of this protein available

> for the

> transportation of thyroid hormone.

>

> apparently caffeine can detach the bilirubin from

> this protein and

> possibly free the protein up for better thyroid

> distribution. (this

> is a theory by the guy that created gilberts

> syndrome.com) but this

> could also explain why i temporarily got my libido

> back the night i

> did a really strong coffee enema.

>

> it seems there's a few things you can take to

> improve gilberts

> syndrome or phase two detoxification pathways.

>

> Phenobarbital is one thing but it kind of scares me

> as its a powerful

> drug, but on the gilberts syndrome web sight there's

> a few people

> that say it works for them, they take it for a

> couple of weeks and

> they say its effects clear there systems for about

> six months before

> they need it again.

>

> http://en.wikipedia.org/wiki/Phenobarbital

>

>

> another thing is u.v light sunlight breaks down

> bilirubin so the

> lesser amount would free up the protein that

> transports thyroid

> hormone and possibly bring back some sex drive due

> to a higher

> thyroid level. (just a theory but could this explain

> the consistently

> higher amount of pssd posts 3 years on the run

> during the winter

> months?)

>

> http://health.groups.yahoo.com/group/SSRIsex/

>

> im looking into supplements for gilberts syndrome at

> the moment and

> will post the ones i find beneficial here.

>

> but one thing i did come across is b3 (niacin)

> apparently it

> shouldn't be taken by people with gilberts syndrome

> as it does

> increase serum levels of bilirubin shortly after

> consumption, i found

> this interesting because i know some people on here

> have been taking

> it in high amounts accompanying it with infra red

> saunas.

>

> i know at least one of you that's done this has had

> a dramatic

> improvement from pssd (bicker, i think) and he

> noticed that his pssd

> got worce while doing this and his improvement came

> on later.

>

> high dose b3 would have increased his bilirubin

> levels even if he

> didn't have gilberts syndrome, but even though b3

> increases bilirubin

> levels it still could be this increase and expulsion

> of bilirubin

> that contributed to his improvments.

>

> personally speaking, i think its possible for most

> if not all of us

> on here to have some or one of the gene's or

> mutations in gene's

> associated with gilberts syndrome and its this

> that's effected the

> ssris metabolism.

>

>

>

>

>

>

>

>

> >

> > seen as though some people on here ive spoke to

> have gilberts

> syndrome

> > as well as my self, i thought id start this post

> to discuss it and

> put

> > this link up with comprehensive information about

> the condition.

> >

> > http://www.gilbertssyndrome.com/

> >

>

>

>

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[Guest guest]

i believe its got something to do with the medical profession wanting

to regard it as something that's not really an issue. (OR BECAUSE ITS

SOMETHING THEY WANT TO COVER UP, AS IT COULD PROVE TO BE THE REASON

FOR MILLIONS OF PEOPLES ADVERCE DRUG REACTIONS & INJURRYS! & THE FACT

THEY NEVER INCLUDE ANYONE WITH ANY OF THE ASSOSIATED GENES IN ANY

CLININCAL TRIALS, TO MAKE THERE DRUGS LOOK SQUICKY CLEAN)

having read into it its complex at best and they have no real way to

treat it.

the different gene mutations they have found in gilberts says that

everyone is different or could possibly be categorised as type 1 or 2

and so on, any treatments developed would have to take this into

account and its only recently that genetic tests have become

available to differentiate between them.

the drug company's arnt going to spend money looking for physical

reasons why a percentage of the population dont require there

psychiatric drugs, its much easier to tell them whats wrong with them

is psychological & then try to get them hooked on a psych drug that

will cause problems which will require other drugs and when the

person turns round to them and says your drug caused this to happen

to me! they turn round and say you need another drug.

an interesting thing about gilberts syndrome is its more prevalent in

men than women, the enzyme that is deficient is the one that is

directly used for elimination of sex hormones, it doesn't show up on

any tests before puberty because the increase in sex hormones hasn't

compromised the deficient enzyme enough for it to start showing an

elevated bilirubin level on a routine blood test.

this is interesting because you still have got the condition i.e. the

genes and mutations of the genes to cause the condition but you

haven't been diagnosed. (i had a blood test when i was 8 & there was

nothing wrong with it, i didn't have gilberts syndrome)

guys have more sex hormones than women (enough to compromise the

enzyme & show up on a test) and this could be the reason why its more

prevalent in men than women, it doesn't mean that the women not

diagnosed with it dont have some at least of the responsible genes or

gene mutations!

its even possible for guys that haven't been diagnosed with it to

have some of these genes!

reading that web sight there's even links to some of the genes and

mutations regarding serotonin! (which was really interesting to find,

because its maybe possible for some people on here to also have them,

even if they haven't been diagnosed with gilberts syndrome!)

here's some links of links associated with some of these genes and

serotonin.

http://www.ncbi.nlm.nih.gov/pubmed/15761113?dopt=Abstract

" This appears to be saying that the UGT1A6(*2) polymorphism

associated with Gilbert's Syndrome causes glucuronidation twice as

fast as normal. Substrates of UGT1A6 include serotonin, 5-

hydroxytryptophol, 4-nitrophenol, acetaminophen, and valproic acid "

http://dmd.aspetjournals.org/cgi/content/full/31/1/133

" Serotonin is a highly selective substrate for UGT1A6. Serotonin UGT

activity varied by more than 40-fold among human livers. "

theses a possibility that there maybe something behind all this,

here's a link to the gene mutations associated with gilberts syndrome

(that other undiagnosed people could be carriers of)

http://gilbertssyndrome.com/mutations.php

> > >

> > > seen as though some people on here ive spoke to

> > have gilberts

> > syndrome

> > > as well as my self, i thought id start this post

> > to discuss it and

> > put

> > > this link up with comprehensive information about

> > the condition.

> > >

> > > http://www.gilbertssyndrome.com/

> > >

> >

> >

> >

>

>

>

>

______________________________________________________________________

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> Be a better friend, newshound, and

> know-it-all with Yahoo! Mobile. Try it now.

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>

[Guest guest]

not to rule out the possible presence of one of the genes or gene

mutations involved in gilberts syndrome though causing similar

effects.

or possibly the element of slight hypothyroidism.

> >

> > Nemo,

> >

> > I just looked into gilberts syndrome. Although i

> > have not been diagnosed with it,i can say that i

> > suffer from most of the symptoms, with the exception

> > of yellow eyes and skin.

>

[Guest guest]

*bingo* just found some evidence that backs up my theory about a

genetic link with pssd, gilberts syndrome & those with pssd that

haven't got gilberts syndrome.

it does seem to be correct that other people that have not been

diagnosed with gilberts syndrome can be carriers of at least one of

the genes involved in the condition with out having gilberts syndrome.

" more than half the people in the general population carry one copy

of this abnormal gene, making it very common. If two people with this

abnormal gene have a child, they may pass along the genetic defect

that causes Gilbert's — but not always. Not everyone who has two

copies of this abnormal gene gets Gilbert's syndrome. This means you

may have the condition without a family history of it. In contrast,

everyone with Gilbert's does have two copies of this abnormal gene. "

after finding out this information i think it very possible that a

common denominator in most if not all with pssd could be this gene, i

suppose its also possible for even someone that is just a carrier of

one gene to also have some or one of the subsection mutations

involved in the condition.

http://edition.cnn.com/HEALTH/library/DS/00743.html

> > >

> > > Nemo,

> > >

> > > I just looked into gilberts syndrome. Although i

> > > have not been diagnosed with it,i can say that i

> > > suffer from most of the symptoms, with the exception

> > > of yellow eyes and skin.

> >

>

[Guest guest]

As of yet there is no " evidence " as such that there is a link.

You think tat there is a link, and some people have found that they

have similar symptoms to that syndrome. However, there is no " evidence "

of a link as far as I can see, or maybe I missed it.

You have to remember that when people are suffering from symptoms like

this, it is very easy to imagine that they have every disease in the

medical book. For instance, I thought I had a bacterial infection that

I had read about.

To mention " evidence " at the beggining may be misleading. If you beleve

that there is a link, maybe you could ask your G.P about it?

[Guest guest]

theres about 10-15 people on here that post regular, out of those 10-

15 with pssd there is 3 with gilberts, pssd seems more prevalent in

those that have gilberts or they are more susceptible to pssd. only

1 in 100 people have gilberts.

3 in 15 could be a coincidence, however statistically speaking its

remarkable that there is 1 at all amongst the 10-15 people on here

that ive spoken to.

ive recently found out that 50% of the population are carriers of at

least one of the genes involved in gilberts but they dont have the

condition.

i recon this points to somthing, its just my oppinion but id bet

money on the fact that the vast majority with pssd have one of the

genes involved and not just 50%.

ive found links with the genes effects on serotonin, this also points

to some thing in my oppinion.

>

> As of yet there is no " evidence " as such that there is a link.

>

> You think tat there is a link, and some people have found that they

> have similar symptoms to that syndrome. However, there is

no " evidence "

> of a link as far as I can see, or maybe I missed it.

>

> You have to remember that when people are suffering from symptoms

like

> this, it is very easy to imagine that they have every disease in

the

> medical book. For instance, I thought I had a bacterial infection

that

> I had read about.

>

> To mention " evidence " at the beggining may be misleading. If you

beleve

> that there is a link, maybe you could ask your G.P about it?

>