Re: Nutmeg, SAMe, L-Tryptophan

[Guest guest]

You can buy nutmeg at the local gorcery store or at an Indian food

store.

I just brought ground nutmeg and took 1-1.5 teaspoons full. Don't take

mor ethan that because it is not good for you.

[Guest guest]

As to the cannibis, what it really does is releaves the sleep problems

and lack of enegry caused by pssd, and also brings back interest in

sex. It also seemed to have orgasmic qualities.

Yeah, I'm more and more convinced by various drugs used that pssd is

mainly caused by serotonin downregulation at particular sites, as well

as some problem with nitric oxide.

[Guest guest]

Nutmeg is the real deal. WOW...you really discovered a find here. I

have taken Cialis, Levitra, Viagra, Requip, Mirapex, and about every

herb know to help with sexual dysfunction. Nutmeg has increased the

pleasure associated with orgasm since I started taking 1 tsp a couple

days ago. Still hasnt helped penile numbness or erectile dysfunction,

but definately has helped orgasm pleasure. Before it was about a 1 on

the pleasure scale 1-10. With nutmeg its about a 3-4. Still a far

cry from where it was, but there is a definate effect. I am

interested in trying Buspar know, since I read this is a 5ht1 agonist.

[Guest guest]

Yeah it really is the real thing.

Its strange that the physical numbness did not go away, mine

definetely did. I don't think that nutmeg is a good long term

strategy. A better option would be to reduce REM sleep a bit or

improve sleep quality (possibly by increasing nitiric oxide before

sleep and to use some kind of drug to reduce REM sleep.

A lot of people are now touting 5ht1a agonists. Nutmeg acts on the

5ht2a receptors, not the 5ht1a receptors.

A drug which acts as a 5ht1a agonist desnsitizes the 5ht1a receptors.

This then causes a huge influx of serotonin in the brain. That's

exactly what ssris also do.

If this seems to happen to you, I would recomend coming off the drug.

[Guest guest]

The sexual stimulating effects of nutmeg have been proven in mice.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=270058

> Nutmeg has increased the

> pleasure associated with orgasm since I started taking 1 tsp a couple

> days ago. Still hasnt helped penile numbness or erectile dysfunction,

> but definately has helped orgasm pleasure. Before it was about a 1 on

> the pleasure scale 1-10. With nutmeg its about a 3-4.

>

[Guest guest]

Nutmeg seems a very interesting herb for the possible treatment of PSSD.

But eating to much nutmeg causes hallucinations and other unwanted

side effects.

>

> Nutmeg is the real deal. WOW...you really discovered a find here. I

> have taken Cialis, Levitra, Viagra, Requip, Mirapex, and about every

> herb know to help with sexual dysfunction. Nutmeg has increased the

> pleasure associated with orgasm since I started taking 1 tsp a couple

> days ago. Still hasnt helped penile numbness or erectile dysfunction,

> but definately has helped orgasm pleasure. Before it was about a 1 on

> the pleasure scale 1-10. With nutmeg its about a 3-4. Still a far

> cry from where it was, but there is a definate effect. I am

> interested in trying Buspar know, since I read this is a 5ht1 agonist.

>

[Guest guest]

http://en.wikipedia.org/wiki/Nutmeg

> Nutmeg is the real deal.

[Guest guest]

An article about the aphrodisiacal properties of Nutmeg:

http://www.aphrodesiology.com/nutmeg

Vornan> > Nutmeg is the real deal.>

[Guest guest]

Yeah, the reason I tried nutmeg in the first place is because it has

similar properties to MDMA. I don't think that it is usefull as a long

term strategy.

I think what most of my experiences with different drugs and sleep

deprivation suggest is that the 5ht2a and 5ht2c receptors, and possibly

the 5ht1a receptors are the primary causes of PSSD. Another possibility

is that the body just does not feel as though it is " waking up " in the

daytime. PSSD seems to be caused by generally poor waking

emotions,which includes more sensitive 5ht2a receptors, higher levels

of grehlin and nitric oxide, higher levels of oxytocin and endorphins,

higher omoxins and removing the inhibition upon the dopamine,

muscarinic, neuroadrenaline and neuropheraphine receptors.

[Guest guest]

I found an article that suggested that ST. 's Wort could

eventually enhance libido, via blockade of the 5ht1a and 5ht2a

receptors. I am not sure how long you would have to take it in order

to get this effect. It seems to go against a lot of the science

relating to reuptake inhibitors, so i would rather check things out

first. I would also like to know how it effects other systems such as

nitric oxide. Obviously whilst taking st. s Wort, it complteley

destroys libido.

Hypericum perforatum (St 's Wort): a non-selective reuptake

inhibitor? A review of the recent advances in its pharmacology

P.J

Brain Sciences Institute, Swinburne University of Technology

Hypericum possesses a unique pharmacology in that it displays the

pharmacology of many classes of antidepressants and new mechanisms

not typical of standard antidepressants. The most potent of all its

action is the moderate to high potency for inhibition of the reuptake

of monoamines, serotonin, dopamine and noradrenaline and the amino-

acid neurotransmitters GABA and glutamate. Unlike standard reuptake

inhibitors, hypericum exerts this reuptake inhibition non-

competitively by enhancing intracellular Na+ ion concentrations. At a

receptor level, chronic treatment with hypericum downregulates b1-

adrenoceptor, upregulates post-synaptic 5-HT1A receptors and 5-HT2

receptors. Although the major constituent responsible for the

antidepressant effect is thought to be hyperforin, other constituents

such as hypericin, pseudohypericin, flavonoids and oligomeric

procyanidines may also play a direct or indirect role. While reuptake

inhibition may more than likely be responsible for most of the

antidepressant effect, other mechanisms may also contribute alone or

in combination to exert the overall antidepressant action

[Guest guest]

Something to remember about St. 's Wort is that is can cause

blood-pressure issues.

pssd24 wrote:

> I found an article that suggested that ST. 's Wort could

> eventually enhance libido, via blockade of the 5ht1a and 5ht2a

> receptors. I am not sure how long you would have to take it in order

> to get this effect. It seems to go against a lot of the science

> relating to reuptake inhibitors, so i would rather check things out

> first. I would also like to know how it effects other systems such as

> nitric oxide. Obviously whilst taking st. s Wort, it complteley

> destroys libido.

>

> Hypericum perforatum (St 's Wort): a non-selective reuptake

> inhibitor? A review of the recent advances in its pharmacology

> P.J

> Brain Sciences Institute, Swinburne University of Technology

>

> Hypericum possesses a unique pharmacology in that it displays the

> pharmacology of many classes of antidepressants and new mechanisms

> not typical of standard antidepressants. The most potent of all its

> action is the moderate to high potency for inhibition of the reuptake

> of monoamines, serotonin, dopamine and noradrenaline and the amino-

> acid neurotransmitters GABA and glutamate. Unlike standard reuptake

> inhibitors, hypericum exerts this reuptake inhibition non-

> competitively by enhancing intracellular Na+ ion concentrations. At a

> receptor level, chronic treatment with hypericum downregulates b1-

> adrenoceptor, upregulates post-synaptic 5-HT1A receptors and 5-HT2

> receptors. Although the major constituent responsible for the

> antidepressant effect is thought to be hyperforin, other constituents

> such as hypericin, pseudohypericin, flavonoids and oligomeric

> procyanidines may also play a direct or indirect role. While reuptake

> inhibition may more than likely be responsible for most of the

> antidepressant effect, other mechanisms may also contribute alone or

> in combination to exert the overall antidepressant action

>

>

>

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[Guest guest]

Hello Everyone,

Long time no post. I've tried numerous things with mixed results. I

became curious after reading pssd24's posts on nutmeg and it's

possible effects. I decided to try a much lower dose than he suggested

due to a sensitive constitution and to be cautious.

A dose of ~1/8th tsp, perhaps less, taken 6 hours ago has had a

noticeably positive effect on emotional depth.

However, I feel physically hot after taking this, so it might have

still been too high of a dose.

I'm working with a chinese herbalist right now, and symptoms like that

indicate too much " heat " in the body.

[Guest guest]

This kind of overheating is most probably caused by the serotonin

receptors. MDMA, which has a similar structure, causes similar effects.

As I have mentioned before, nutmeg is not a cure for pssd. I would not

recomend that you keep taking it.

I think pssd is more likely to be caused by sleep problems due to

problems with 5ht1a receptor, 5ht2a receptor, and nitric oxide.

[Guest guest]

what was chinese herbalist opinion or diagnoses ?

>

> Hello Everyone,

>

> Long time no post. I've tried numerous things with mixed results. I

> became curious after reading pssd24's posts on nutmeg and it's

> possible effects. I decided to try a much lower dose than he suggested

> due to a sensitive constitution and to be cautious.

>

> A dose of ~1/8th tsp, perhaps less, taken 6 hours ago has had a

> noticeably positive effect on emotional depth.

>

> However, I feel physically hot after taking this, so it might have

> still been too high of a dose.

>

> I'm working with a chinese herbalist right now, and symptoms like that

> indicate too much " heat " in the body.

>

[Guest guest]

I was working a stressful IT Job for a while, and I originally went to

see my herbalist for irritability and random nosebleeds I was getting.

He managed to stop both of those with herbs and a little acupuncture

here and there. It took about a month and a half. At one point, the

herbs he had me on were so mellowing, I was actually getting good gas

mileage.

I came in focussed more on stress and general health, rather and

trying to fix PSSD right away, because that mentality made me too

frustrated in the past. So, I only recently brought it up.

Anyway, the diagnosis for Chinese medicine is a little different.

Nosebleeds, Irritability, tension in the neck, and Insomnia were from

excess heat in the body for me. He said that in order to get a clear

picture of underlying imbalances or deficiencies, the heat had to be

cleared (I think that things like D2 agonists, stimulants, typical

libido boosting herbs would be considered heat increasing and were not

appropriate in my case at the time I tried them).

Now he's cleared alot of the heat and is starting to work on different

imbalances in the organ systems. The organ systems are looked at much

differently in Chinese medicine it would take a while to explain.

But how they diagnose you is by looking at your tongue and feeling

pulses of the various organs (yes they consider there to be more than

one pulse). My tongue for example was very red, especially at the tip,

and now it has actually moderated in appearance a good deal.

I can't say how this would correspond to things like dopamine and 5ht2

receptor desensitization, as it's a more holistic system that looks at

the body in a completely different way.

As for nutmeg, it is actually used sometimes in the system, but

usually for certain digestive issues and at low doses. He said it was

definitely warming, but that I could try still it at maybe half the

dose I took, but not very often.

> >

> > Hello Everyone,

> >

> > Long time no post. I've tried numerous things with mixed results. I

> > became curious after reading pssd24's posts on nutmeg and it's

> > possible effects. I decided to try a much lower dose than he suggested

> > due to a sensitive constitution and to be cautious.

> >

> > A dose of ~1/8th tsp, perhaps less, taken 6 hours ago has had a

> > noticeably positive effect on emotional depth.

> >

> > However, I feel physically hot after taking this, so it might have

> > still been too high of a dose.

> >

> > I'm working with a chinese herbalist right now, and symptoms like that

> > indicate too much " heat " in the body.

> >

>

[Guest guest]

Whatever. It increases heat because it stimulates 5ht receptors.

[Guest guest]

Ive always noticed when I was on ssri and off of it afterward I would

always burn up easily and feel extremely hot. Im not sure if this is

due to because my body is acutally getting hotter or colder

since when we catch a flu or cold , we acutally feel cold or freezing

when acutally our body temp goes up. When sometimes I experienced

relief from Pssd I noticed I was less hot ,colder and felt less

physical pain. Like youve mentioned I also experienced when I tried

sex herbs or dopamine supplements I experienced even more heat and

anger. I dont know exactly whats going on but Im very hot flashy,

angry , and reduced ability to fight physical pain. I feels like my

whole body is inflamed or bloated. Its wierd that i feel now that I

have less fat than I used to and more cut with defined muscles but

interestnly muscles seem a lot flabby.

> > >

> > > Hello Everyone,

> > >

> > > Long time no post. I've tried numerous things with mixed

results. I

> > > became curious after reading pssd24's posts on nutmeg and it's

> > > possible effects. I decided to try a much lower dose than he

suggested

> > > due to a sensitive constitution and to be cautious.

> > >

> > > A dose of ~1/8th tsp, perhaps less, taken 6 hours ago has had a

> > > noticeably positive effect on emotional depth.

> > >

> > > However, I feel physically hot after taking this, so it might

have

> > > still been too high of a dose.

> > >

> > > I'm working with a chinese herbalist right now, and symptoms

like that

> > > indicate too much " heat " in the body.

> > >

> >

>

[Guest guest]

When you first start taking ssri's, there is a massive amount of

serotonin stimulating the 5ht1a receptors. This causes increase in body

temperature, because the 5ht1a receptors are involved in regulating

temperature. Some people also experience extreme heat, fever,

hallucinations etc. this is a sign of serotonin syndrome, when huge

amounts of serotnin are released upon 5ht1a and possibly 5ht2a

receptors. If serotonin syndrome gets really bad you can feint, or even

die.

After a while, your 5ht1a receptors downregulate, which makes you heat

up less due to the increase of serotonin. This also causes an increse

in the serotonin and gaba released.