Difficulty finding reliable articles about 5ht1a and 5ht2a upregulation

[Guest guest]

I am finding that a lot of articles about 5ht1a and 5ht2a upregulation

are just not matching up.

Some articles suggest that 5ht1a agonists " resensitize, "

or " upregulate " 5ht1a receptors.

Other articles suggest the opposite, that 5ht1a agonists

gradually " downregulate " 5ht1a receptors, exerting a similar effect to

ssris.

I tried a 5ht1a agonist for a few days, although I felt very tired at

the time. I remember that after a few ays I started to have an unusual

improvement in energy and awakeness.