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I have had my bioavailable testosterone checked. It is actually mid-

high!

Nitro FX, which raises Nitric Oxide levels is quite usefull. It isn't

really great as far as I can tell though.

I've been wondering recently, is one of the major problems with pssd

having really sevre tension, stress and poor concentration?

I have very bad backache, suffer from sevre tension, irritable bowel

syndrome, irritability, innability to concentrate, and really severe

tiredness and fatigue.

I have stopped masturbating for a while. This seems to have improved

things a bit, like now I am getting erections at night time again. I

think maybe it is important to have a break every now and again in

order to recover dopamine levels etc.

However, even when my dopamine was really high I could not get

erections (this was whilst taking zyban).

I belive that there may also be a link with Nitric Oxide as well, but

morover I feel like my body is too stressed and fatigued to get proper

erections. This seems to express itself as pains in various parts of my

body and very bad concentration etc.

Does anyone else have sympoms like this? I would like to know as I may

have other problems that are unrelated to pssd.

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My husband had pretty much identical symptoms and went repeatedly to

the doctor every couple of months for about a year saying " something is

WRONG " . (This started at pretty much the same time as the PSSD.)

The doc would test his blood and tell him everything was fine. Then a

few months a go one test came back that his thyroid was low, so they

started him on desiccated thyroid. It helped for a while but not for

long so he went back. Next test showed that his thyroid was even

lower, so they upped the thyroid meds.

This cycle kept repeating itself until his thyroid meds are now quite

high. He felt good for about a month on this last increase, but is

starting to feel tired again.

My suggestion, have your thyroid tested ... repeatedly. For some

reason low thyroid hormones seem to take a long time to show up on the

tests. If it's low, see if your doctor will prescribe the desiccated

thyroid (Armour thyroid) as it contains both t-3 and t-4 while most of

the synthetic thyroid only contains t-4 which doesn't always help

fatigue levels.

For more information on this check out the comprehensive site:

http://www.stopthethyroidmadness.com/

>

>

> I have very bad backache, suffer from sevre tension, irritable bowel

> syndrome, irritability, innability to concentrate, and really severe

> tiredness and fatigue.

>

>

> Does anyone else have sympoms like this? I would like to know as I

may

> have other problems that are unrelated to pssd.

>

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I have already had my thyroid tested several times and it was fine on

the last check. I believe my problems are more likely to be caused by

depression. I am hoping that stablon will help to improve things.

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nitro fx like noni juce will only put more nitric oxide into your

blood and that is broken down by the enzyme pde5.

its nitric oxide synthesis thats the real problem.

some of things you have said could be put down to hypothyroid.

>

> I have had my bioavailable testosterone checked. It is actually mid-

> high!

>

> Nitro FX, which raises Nitric Oxide levels is quite usefull. It

isn't

> really great as far as I can tell though.

>

> I've been wondering recently, is one of the major problems with

pssd

> having really sevre tension, stress and poor concentration?

>

> I have very bad backache, suffer from sevre tension, irritable

bowel

> syndrome, irritability, innability to concentrate, and really

severe

> tiredness and fatigue.

>

> I have stopped masturbating for a while. This seems to have

improved

> things a bit, like now I am getting erections at night time again.

I

> think maybe it is important to have a break every now and again in

> order to recover dopamine levels etc.

>

> However, even when my dopamine was really high I could not get

> erections (this was whilst taking zyban).

>

> I belive that there may also be a link with Nitric Oxide as well,

but

> morover I feel like my body is too stressed and fatigued to get

proper

> erections. This seems to express itself as pains in various parts

of my

> body and very bad concentration etc.

>

> Does anyone else have sympoms like this? I would like to know as I

may

> have other problems that are unrelated to pssd.

>

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did they just do a tsh test? or did they do a full thyroid panel?

the tsh test is useless in detecting border line hyper or hypo

thyroid.

>

> I have already had my thyroid tested several times and it was fine

on

> the last check. I believe my problems are more likely to be caused

by

> depression. I am hoping that stablon will help to improve things.

>

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I believe it is a problem with the entire nervous system in my case.

I have been abel to get very strong erections using levitra and amyl

nitrates. However, I still cannot get spontanious erections, even

though after a while I can get very strong erections.

Take another good look at the post I made on nitric oxide signalling.

Like I said, whilst taking MDMA I was able to get erections. I

believe that this was caused via the same system.

> >

> > I have had my bioavailable testosterone checked. It is actually

mid-

>

> > high!

> >

> > Nitro FX, which raises Nitric Oxide levels is quite usefull. It

> isn't

> > really great as far as I can tell though.

> >

> > I've been wondering recently, is one of the major problems with

> pssd

> > having really sevre tension, stress and poor concentration?

> >

> > I have very bad backache, suffer from sevre tension, irritable

> bowel

> > syndrome, irritability, innability to concentrate, and really

> severe

> > tiredness and fatigue.

> >

> > I have stopped masturbating for a while. This seems to have

> improved

> > things a bit, like now I am getting erections at night time

again.

> I

> > think maybe it is important to have a break every now and again

in

> > order to recover dopamine levels etc.

> >

> > However, even when my dopamine was really high I could not get

> > erections (this was whilst taking zyban).

> >

> > I belive that there may also be a link with Nitric Oxide as well,

> but

> > morover I feel like my body is too stressed and fatigued to get

> proper

> > erections. This seems to express itself as pains in various parts

> of my

> > body and very bad concentration etc.

> >

> > Does anyone else have sympoms like this? I would like to know as

I

> may

> > have other problems that are unrelated to pssd.

> >

>

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if mdma increases serotonin its likely the increase is being recycled

through the serotonin transporter as it should do.

its uptake of serotonin that synthesis nitric oxide in the brain,

they mediate each other and this mediation should be ballenced. the

ssris have upset this balance, when you get tired serotonin decreases

allowing you to more easily respond to sexual thoughts as serotonin

is not getting in the way as much.

its enhancement of serotonin pathways thats getting in the way of

responding to anything erotic.

maybe an fmri brain scan is enough to damage the new probably more

delicate connections that have been made in the brain.

> > >

> > > I have had my bioavailable testosterone checked. It is actually

> mid-

> >

> > > high!

> > >

> > > Nitro FX, which raises Nitric Oxide levels is quite usefull. It

> > isn't

> > > really great as far as I can tell though.

> > >

> > > I've been wondering recently, is one of the major problems with

> > pssd

> > > having really sevre tension, stress and poor concentration?

> > >

> > > I have very bad backache, suffer from sevre tension, irritable

> > bowel

> > > syndrome, irritability, innability to concentrate, and really

> > severe

> > > tiredness and fatigue.

> > >

> > > I have stopped masturbating for a while. This seems to have

> > improved

> > > things a bit, like now I am getting erections at night time

> again.

> > I

> > > think maybe it is important to have a break every now and again

> in

> > > order to recover dopamine levels etc.

> > >

> > > However, even when my dopamine was really high I could not get

> > > erections (this was whilst taking zyban).

> > >

> > > I belive that there may also be a link with Nitric Oxide as

well,

> > but

> > > morover I feel like my body is too stressed and fatigued to get

> > proper

> > > erections. This seems to express itself as pains in various

parts

> > of my

> > > body and very bad concentration etc.

> > >

> > > Does anyone else have sympoms like this? I would like to know

as

> I

> > may

> > > have other problems that are unrelated to pssd.

> > >

> >

>

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Actually I think MDMA forces all the serotonin into the synapse and

also inhibits its reuptake.

However, I think it also stimulates the central nervouse system. In the

later stages it also forces dopamine and MAO into the synapses (which

is toxic) and increases NO.

At the same time it inhibits the reuptake of dopamine and increaes

oxytopin.

Scientists do not know why it enhances libido. Some scientists say that

it does not (probably because they do not understand how it works).

I got this information from that article I found on MDMA, cocain, and

slepp deprivation ages ago. I will try to post it again this week.

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i think its effects are because lots of serotonin is released but its

also taken back up by the transporter which stimulates nitric oxide

synthesis.

>

> Actually I think MDMA forces all the serotonin into the synapse and

> also inhibits its reuptake.

>

> However, I think it also stimulates the central nervouse system. In

the

> later stages it also forces dopamine and MAO into the synapses

(which

> is toxic) and increases NO.

>

> At the same time it inhibits the reuptake of dopamine and increaes

> oxytopin.

>

> Scientists do not know why it enhances libido. Some scientists say

that

> it does not (probably because they do not understand how it works).

>

> I got this information from that article I found on MDMA, cocain,

and

> slepp deprivation ages ago. I will try to post it again this week.

>

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No, I don't think it's that. MDMA increases orgasm quality, and

libido as well. It is proabably a coctail of chemicals such as

oxytopin, dopamine and adrenaline. The serotonin stops the effects of

the erection. Like I have said MDMA causes a toxic reaction, it

forces dopamine and MAO into the serotonin synapse. This causes

release of nitric oxide.

You are placing too much on the idea of raised blood serotonin and

No.

> >

> > Actually I think MDMA forces all the serotonin into the synapse

and

> > also inhibits its reuptake.

> >

> > However, I think it also stimulates the central nervouse system.

In

> the

> > later stages it also forces dopamine and MAO into the synapses

> (which

> > is toxic) and increases NO.

> >

> > At the same time it inhibits the reuptake of dopamine and

increaes

> > oxytopin.

> >

> > Scientists do not know why it enhances libido. Some scientists

say

> that

> > it does not (probably because they do not understand how it

works).

> >

> > I got this information from that article I found on MDMA, cocain,

> and

> > slepp deprivation ages ago. I will try to post it again this week.

> >

>

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ive not even mentioned blood serotonin, what im referring to is

synaptic serotonin and the mutated synaptic connections created by

the ssris.

> > >

> > > Actually I think MDMA forces all the serotonin into the synapse

> and

> > > also inhibits its reuptake.

> > >

> > > However, I think it also stimulates the central nervouse

system.

> In

> > the

> > > later stages it also forces dopamine and MAO into the synapses

> > (which

> > > is toxic) and increases NO.

> > >

> > > At the same time it inhibits the reuptake of dopamine and

> increaes

> > > oxytopin.

> > >

> > > Scientists do not know why it enhances libido. Some scientists

> say

> > that

> > > it does not (probably because they do not understand how it

> works).

> > >

> > > I got this information from that article I found on MDMA,

cocain,

> > and

> > > slepp deprivation ages ago. I will try to post it again this

week.

> > >

> >

>

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There is no way of knowing that you do have raised serotonin levels.

You say that you feel happy and relaxed a lot of the time. I think this

could be caused by problems with REM sleep. It could be desensitized

5htp1a receptors in the forebrain causing problems with deep sleep.

These problems with sleep could make you feel more spaced out, day-

dreamy, relaxed, underexcited. These changes in sleep are likely to

lead to changes in brainwaves.

In some respects I agree with you. However, not for the same reasons.I

think that lowered levels of grehlin lead to incvreased serotonin

release.

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you mean changes in sleep would effect daytime brainwave patterns?

>

> There is no way of knowing that you do have raised serotonin

levels.

> You say that you feel happy and relaxed a lot of the time. I think

this

> could be caused by problems with REM sleep. It could be

desensitized

> 5htp1a receptors in the forebrain causing problems with deep sleep.

>

> These problems with sleep could make you feel more spaced out, day-

> dreamy, relaxed, underexcited. These changes in sleep are likely to

> lead to changes in brainwaves.

>

> In some respects I agree with you. However, not for the same

reasons.I

> think that lowered levels of grehlin lead to incvreased serotonin

> release.

>

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It is the sleep deprivation caused by ssri's that causes dopamine to

be downgraded. Certain typers of sleep downgrade dopamine. If REM

sleep is supressed, dopamine will also be disrupted. Dopamine is

generally upregulated at night during sleep. The dhtp1a repectors are

integral for sleep maintanance.

http://www.springerlink.com/index/EEEX04HH9RY84AP2.pdf

We always look at the serotonin system as the " happy " system, but

that is an oversimplification. The 5htp1a receptors (which are the

most badly damaged during serotonin toxidity) actually control sleep

and eating.

Therefore, if you damage those nerve endings, you get weird sleeping

patters, making you feel fuzzy, sleepy and happy in the morning, and

really run down and agitated in the evening. If you look at what it's

actually doing to us, it is probably quite close to parkinsons, or

narcolepsy.

If you damaged that, it would also cause problems with hunger. Hunger

promotes greater nitric oxide and upgrades the arousal system.

All of this stuff is caused by serotnin syndrome, which damages the

5htp1a receptors.

Its possible that it damages the 5htp2 receptors too. I'm not sure.

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monoamine neurotransmitters are shut down during rem sleep, this is

when you get night time erections.

>

> It is the sleep deprivation caused by ssri's that causes dopamine

to

> be downgraded. Certain typers of sleep downgrade dopamine. If REM

> sleep is supressed, dopamine will also be disrupted. Dopamine is

> generally upregulated at night during sleep. The dhtp1a repectors

are

> integral for sleep maintanance.

>

> http://www.springerlink.com/index/EEEX04HH9RY84AP2.pdf

>

> We always look at the serotonin system as the " happy " system, but

> that is an oversimplification. The 5htp1a receptors (which are the

> most badly damaged during serotonin toxidity) actually control

sleep

> and eating.

>

> Therefore, if you damage those nerve endings, you get weird

sleeping

> patters, making you feel fuzzy, sleepy and happy in the morning,

and

> really run down and agitated in the evening. If you look at what

it's

> actually doing to us, it is probably quite close to parkinsons, or

> narcolepsy.

>

> If you damaged that, it would also cause problems with hunger.

Hunger

> promotes greater nitric oxide and upgrades the arousal system.

>

> All of this stuff is caused by serotnin syndrome, which damages the

> 5htp1a receptors.

>

> Its possible that it damages the 5htp2 receptors too. I'm not sure.

>

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