Re: Depression and gene expression, partial reversal by imipramine

[Guest guest]

Imipramine upregulates 5ht2c receptors and also increases nitric

oxide. 5ht2c receptors cause release of dopamine and induce erections.

> > >

> > >

> > > http://www.nimh.nih.gov/press/bdnfmethylation.cfm

> > > <http://www.nimh.nih.gov/press/bdnfmethylation.cfm>

> > >

> > > I think there are some insights into PSSD here, although the

> paper is

> > > not specifically about that.

> > >

> > > Vornan

> > >

> >

>

[Guest guest]

Are there other studies about imapramine that I'm not aware of? I'm

not seeing anything in this one about sexuality.

The thing that jumps out to me the most about this study is how messed

up the rats were based on stress alone. My symptoms began after

switching from Celexa to Fluoxetine, it's true, but the REASON I

switched was because of a great deal of stress - which was closely

connected to an extended and constant barrage of social defeat, just

like those rats. This is not something I can overlook - it was 18

months of a very bad situation that led up to my decision to quit, and

Celexa never affected me this way at all.

What kinds of drugs are used for stress-related conditions? I'm not

talking about depression, I'm talking about trauma that has left a

real mark. Maybe that's what I should be looking at.

--

> >

> >

> > http://www.nimh.nih.gov/press/bdnfmethylation.cfm

> > <http://www.nimh.nih.gov/press/bdnfmethylation.cfm>

> >

> > I think there are some insights into PSSD here, although the paper is

> > not specifically about that.

> >

> > Vornan

> >

>

[Guest guest]

If you're talking about stress, as in PTSD, there are

no medications that effective. The procedure for

treating PTSD with drugs is to treat it

symptomatically (insomnia, depression, anxiety,

etc...) not treat the PTSD directly with any specific

drugs.

--- mrmanguy84 wrote:

> Are there other studies about imapramine that I'm

> not aware of? I'm

> not seeing anything in this one about sexuality.

>

> The thing that jumps out to me the most about this

> study is how messed

> up the rats were based on stress alone. My symptoms

> began after

> switching from Celexa to Fluoxetine, it's true, but

> the REASON I

> switched was because of a great deal of stress -

> which was closely

> connected to an extended and constant barrage of

> social defeat, just

> like those rats. This is not something I can

> overlook - it was 18

> months of a very bad situation that led up to my

> decision to quit, and

> Celexa never affected me this way at all.

>

> What kinds of drugs are used for stress-related

> conditions? I'm not

> talking about depression, I'm talking about trauma

> that has left a

> real mark. Maybe that's what I should be looking at.

>

> --

>

>

>

>

>

> > >

> > >

> > >

> http://www.nimh.nih.gov/press/bdnfmethylation.cfm

> > >

> <http://www.nimh.nih.gov/press/bdnfmethylation.cfm>

> > >

> > > I think there are some insights into PSSD here,

> although the paper is

> > > not specifically about that.

> > >

> > > Vornan

> > >

> >

>

>

>

[Guest guest]

I've really found that tumeric may be one of the best things for

depression and stress. People are often reluctant to belive that

something so basic cvould work, but if you look, it upregulates 5ht1a

receptors, also interacts with 5ht1b and 5htt2c receptors, and raises

both serotonin and dopamine levels. It has been used in China for

thousands of years.

However, I do think that some of the advice you have been given below

is correct. For very traumatic events maybe seek therapy or a

psyuchologist. Medication itself would only act as a buffer.

> > > >

> > > >

> > > >

> > http://www.nimh.nih.gov/press/bdnfmethylation.cfm

> > > >

> > <http://www.nimh.nih.gov/press/bdnfmethylation.cfm>

> > > >

> > > > I think there are some insights into PSSD here,

> > although the paper is

> > > > not specifically about that.

> > > >

> > > > Vornan

> > > >

> > >

> >

> >

> >

>