Re: RESEARCH - Adipose tissue has anti-inflammatory properties; focus on IL-1 re

[Guest guest]

Actually, I've just skimmed the artical, but to put it in lay terms...

Inflamation can make you fat!!

It isn't unusual, if you consider that certain fats and oils can cause

or foster inflamation in the tissues of the body. I am thinking of all

the deep fried and fatty food Americans eat. Our diet is loaded with

things that make inflamation WORSE. Inflamation is one of the major

avenues of cardiovascular disease [ another problem for those with RA,

risks are CVD are increased due to systemic inflamation]

Considering, from the subjective reports of others in my group, almost

everyone of the RA patients I know actually put on weight at the

outset of their illness, [ACR's stated syptom of weight loss] and

actually lost the " extra " weight without diet or exercise when their

inflamatory process was abated [ with a medication that was not a

steroid].

The bypass patients will have less inflamation because they will lose

white fat [ which is the more inert fat on the body that houses . The

metabolically active fat on the body is brown fat and this does not

contribute to inflamation].. basically white fat is like missile

silos for the immune system. this tissue house hormones and inflamtory

mediators just waiting for to go off...

Now another reason to keep your body fat down , but also a reason if

your have an inflamatory disease you might have trouble losing

weight... even if you diet and exercise....

> >

> > Ann N Y Acad Sci. 2006 Jun;1069:444-53.

> >

> > Adipose tissue has anti-inflammatory properties: focus on IL-1

> receptor antagonist (IL-1Ra).

> >

> >

> > Division of Immunology & Allergy, University Hospital/Faculty of

> Medicine, 1211 Geneva 14, Switzerland. jean-michel.dayer@

> > The formation of adipose tissue could result from abnormal

> metabolic processes and, at the local level, from chronic

> inflammatory processes such as those occurring in the synovial cavity

> in rheumatoid arthritis or osteoarthritis, or the peritoneal cavity

> in various inflammatory processes of the digestive system. Adipocytes

> are said to produce many hormones and proinflammatory mediators. So

> far, however, little attention has been paid to cytokine inhibitory

> molecules. Based on our observation of high levels of serum

> interleukin receptor antagonist (IL-1Ra) in obese patients

> contrasting with decreased levels after gastric bypass surgery, we

> found white adipose tissue (WAT) in the human system to be the main

> source of IL-1Ra. IL-10 was also present in WAT. Furthermore, we

> found that interferon-beta (IFN)-beta was the principal cytokine

> inducing IL-1Ra in various WAT, such as that present in the synovium.

> We suggest that in addition to other functions adipose tissue may

> give rise to a host-defense mechanism against local inflammation and

> that fibrotic tissue in the vicinity may further induce IL-1Ra in

> adipocytes via the production of IFN-beta.

> > PMID: 16855172

> >

> > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

> db=pubmed & cmd=Retrieve & dopt=AbstractPlus & list_uids=16855172Not an

> MDI'll tell you where to go!Mayo Clinic in

> Rochesterhttp://www.mayoclinic.org/rochesters Hopkins

> Medicinehttp://www.hopkinsmedicine.org

> >

> >