Re: RESEARCH - Adipose tissue has anti-inflammatory properties; focus on IL-1 receptor antagonist (IL-1Ra)

[Guest guest]

Can anyone explain this is lay terms?.. Is it saying the obese

patients have more inflammation and bypass patients have less? Or is

the other way around?.. or am I missing the point all together?

--- In , " " <Matsumura_Clan@...>

wrote:

>

> Ann N Y Acad Sci. 2006 Jun;1069:444-53.

>

> Adipose tissue has anti-inflammatory properties: focus on IL-1

receptor antagonist (IL-1Ra).

>

>

> Division of Immunology & Allergy, University Hospital/Faculty of

Medicine, 1211 Geneva 14, Switzerland. jean-michel.dayer@...

> The formation of adipose tissue could result from abnormal

metabolic processes and, at the local level, from chronic

inflammatory processes such as those occurring in the synovial cavity

in rheumatoid arthritis or osteoarthritis, or the peritoneal cavity

in various inflammatory processes of the digestive system. Adipocytes

are said to produce many hormones and proinflammatory mediators. So

far, however, little attention has been paid to cytokine inhibitory

molecules. Based on our observation of high levels of serum

interleukin receptor antagonist (IL-1Ra) in obese patients

contrasting with decreased levels after gastric bypass surgery, we

found white adipose tissue (WAT) in the human system to be the main

source of IL-1Ra. IL-10 was also present in WAT. Furthermore, we

found that interferon-beta (IFN)-beta was the principal cytokine

inducing IL-1Ra in various WAT, such as that present in the synovium.

We suggest that in addition to other functions adipose tissue may

give rise to a host-defense mechanism against local inflammation and

that fibrotic tissue in the vicinity may further induce IL-1Ra in

adipocytes via the production of IFN-beta.

> PMID: 16855172

>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

db=pubmed & cmd=Retrieve & dopt=AbstractPlus & list_uids=16855172Not an

MDI'll tell you where to go!Mayo Clinic in

Rochesterhttp://www.mayoclinic.org/rochesters Hopkins

Medicinehttp://www.hopkinsmedicine.org

>

>

[Guest guest]

Faith,

This study found that adipose tissue (connective tissue that stores cellular

fat) produces antiinflammatory cytokines, specifically, IL-1Ra and IL-10.

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[ ] Re: RESEARCH - Adipose tissue has anti-inflammatory

properties; focus on IL-1 receptor antagonist (IL-1Ra)

> Can anyone explain this is lay terms?.. Is it saying the obese

> patients have more inflammation and bypass patients have less? Or is

> the other way around?.. or am I missing the point all together?

>

>

>>

>> Ann N Y Acad Sci. 2006 Jun;1069:444-53.

>>

>> Adipose tissue has anti-inflammatory properties: focus on IL-1

> receptor antagonist (IL-1Ra).

>>

>>

>> Division of Immunology & Allergy, University Hospital/Faculty of

> Medicine, 1211 Geneva 14, Switzerland. jean-michel.dayer@...

>> The formation of adipose tissue could result from abnormal

> metabolic processes and, at the local level, from chronic

> inflammatory processes such as those occurring in the synovial cavity

> in rheumatoid arthritis or osteoarthritis, or the peritoneal cavity

> in various inflammatory processes of the digestive system. Adipocytes

> are said to produce many hormones and proinflammatory mediators. So

> far, however, little attention has been paid to cytokine inhibitory

> molecules. Based on our observation of high levels of serum

> interleukin receptor antagonist (IL-1Ra) in obese patients

> contrasting with decreased levels after gastric bypass surgery, we

> found white adipose tissue (WAT) in the human system to be the main

> source of IL-1Ra. IL-10 was also present in WAT. Furthermore, we

> found that interferon-beta (IFN)-beta was the principal cytokine

> inducing IL-1Ra in various WAT, such as that present in the synovium.

> We suggest that in addition to other functions adipose tissue may

> give rise to a host-defense mechanism against local inflammation and

> that fibrotic tissue in the vicinity may further induce IL-1Ra in

> adipocytes via the production of IFN-beta.

>> PMID: 16855172

>>

>> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

> db=pubmed & cmd=Retrieve & dopt=AbstractPlus & list_uids=16855172Not an

> MDI'll tell you where to go!Mayo Clinic in

> Rochesterhttp://www.mayoclinic.org/rochesters Hopkins

> Medicinehttp://www.hopkinsmedicine.org