Re: High-dose Fish Oil has positive effect on neurotransmitters and brain health

[Guest guest]

DHA from Omega-3 found in Fish Oil:

1: Prostaglandins Leukot Essent Fatty Acids. 2006 Sep;75(3):203-11. Epub 2006 Jul 12.

Versatile roles of docosahexaenoic acid in the prenatal brain: from pro- and anti-oxidant features to regulation of gene expression.

Yavin E.

Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel. ephraim.yavin@...

Docosahexaenoic acid (DHA) is the most ubiquitous polyunsaturated fatty acid (FA) in brain tissue. It is selectively esterified to amino phospholipids (PL) and therefore it is highly prevalent at the cytofacial site of the plasma membrane where it may specifically participate in intracellular events. A highly selective DHA accumulation prior to birth is the result of maternal supply via the placenta through a bio-magnification process. Supplements of DHA via the intra-amniotic route to the fetal rat increase brain DHA levels and also confer neuroprotection to fetuses subjected to global ischemic stress. The protective effect has been attributed to an enhanced free radical scavenging capacity of DHA. Dietary deprivation of linolenic acid (LNA) during the perinatal life on the other hand, resulted in losses of DHA from cerebral PLs [M. Schiefermeier, E. Yavin, n-3 deficient and DHA-enriched diets during critical periods of the developing prenatal rat brain, J. Lipid Res. 43 (2002) 124-131]. LNA deprivation also caused changes in a number of gene markers the identification of which was attained by a labor-intensive suppression subtractive hybridization protocol using mRNA from 2-week-old postnatal brains [E. Yakubov, P. Dinerman, F. Kuperstein, S. Saban, E. Yavin, Improved representation of gene markers on microarray by PCR-select subtracted cDNA targets, Mol. Brain Res. 137 (2005) 110-118]. Most notable was a remarkable elevation of dopamine (DA) receptor (D1 and D2) genes as evaluated by quantitative RT-PCR, SDS-PAGE gel electrophoresis and immunochemical staining [F. Kuperstein, E. Yakubov, P. Dinerman, S. Gil, R. Eylam, N. Salem Jr., E. Yavin, Overexpression of dopamine receptor genes and their products in the postnatal rat brain following maternal n-3 FA dietary deficiency, J. Neurochem. 95 (2005) 1550-1562]. Over-expression of DA receptors has been attributed to a compensatory mechanism resulting from impairment in DA neurotransmitter production, storage and processing. In conclusion, DHA is a versatile molecule with a wide range of actions spanning from participation in cellular oxidative processes and intracellular signaling to modulatory roles in gene expression and growth regulation.

PMID: 16839753 [PubMed - indexed for MEDLINE]

[Guest guest]

According to Dr Stoll and Dr Puri it is best to avoid omega 3

capsules that contain DHA if you want to rebuild your brain and

overcome depression. There are now two makes on the market, VegEpa

and PurEpa. PurEpa seems slightly better. The body can make DHA from

EPA if needed.

I've done my internet searches and taking more than 3.5 mg of DHEA

chronically is not wise. Not only do the effects begin to wear off it

can create other problems in the long run. I take 3.5mg by cutting a

tablet up.

I think any substance that artificially increases serotonin might bad

in the long run. I've just stopped taking 5HTP and I doubt whether

SAM-e is good for you at all. If it is helping you 5HTP might be OK

but have frequent breaks from it.

Taking psycheldelic drugs can mess up your serotonin recepters and

cause HPPD (Hallucigenic Persistant Perception Disorder). Also, they

can trigger depression.

Make sure you are getting plenty of sunlight (30 minutes a day for

four days a week) or take a very high dose of vitamin D a day -

1000IU to 2000IU. It is best to get in the sun between 12 and 3 and

just go slightly pink but no more because if you tan you will stop

making vitamin D. You need the UVB so sunbeds are no good. UVB is

filtered out outside the hours of 12 and 3pm. UVA just ages the skin

and is strong all day.

Make sure you are getting plenty of exercise as this rebuilds the

brain.

They really messed us up didn't they?

Kavy.

>

>

> <http://www.afterthediet.com/omega3.htm>

>

> DHA from Omega-3 found in Fish Oil:

>

>

>

> 1: Prostaglandins Leukot Essent Fatty Acids. 2006 Sep;75(3):203-11.

Epub

> 2006 Jul 12.

>

>

> Versatile roles of docosahexaenoic acid in the prenatal brain: from

pro-

> and anti-oxidant features to regulation of gene expression.

> Yavin E

> <http://www.ncbi.nlm.nih.gov/sites/entrez?

Db=pubmed & Cmd=Search & Term=%22Y\

> avin%20E%22%5BAuthor%

5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Result\

> sPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus> .

>

> Department of Neurobiology, Weizmann Institute of Science, Rehovot,

> Israel. ephraim.yavin@...

>

> Docosahexaenoic acid (DHA) is the most ubiquitous polyunsaturated

fatty

> acid (FA) in brain tissue. It is selectively esterified to amino

> phospholipids (PL) and therefore it is highly prevalent at the

> cytofacial site of the plasma membrane where it may specifically

> participate in intracellular events. A highly selective DHA

accumulation

> prior to birth is the result of maternal supply via the placenta

through

> a bio-magnification process. Supplements of DHA via the intra-

amniotic

> route to the fetal rat increase brain DHA levels and also confer

> neuroprotection to fetuses subjected to global ischemic stress. The

> protective effect has been attributed to an enhanced free radical

> scavenging capacity of DHA. Dietary deprivation of linolenic acid

(LNA)

> during the perinatal life on the other hand, resulted in losses of

DHA

> from cerebral PLs [M. Schiefermeier, E. Yavin, n-3 deficient and

> DHA-enriched diets during critical periods of the developing

prenatal

> rat brain, J. Lipid Res. 43 (2002) 124-131]. LNA deprivation also

caused

> changes in a number of gene markers the identification of which was

> attained by a labor-intensive suppression subtractive hybridization

> protocol using mRNA from 2-week-old postnatal brains [E. Yakubov, P.

> Dinerman, F. Kuperstein, S. Saban, E. Yavin, Improved

representation of

> gene markers on microarray by PCR-select subtracted cDNA targets,

Mol.

> Brain Res. 137 (2005) 110-118]. Most notable was a remarkable

elevation

> of dopamine (DA) receptor (D1 and D2) genes as evaluated by

quantitative

> RT-PCR, SDS-PAGE gel electrophoresis and immunochemical staining [F.

> Kuperstein, E. Yakubov, P. Dinerman, S. Gil, R. Eylam, N. Salem

Jr., E.

> Yavin, Overexpression of dopamine receptor genes and their products

in

> the postnatal rat brain following maternal n-3 FA dietary

deficiency, J.

> Neurochem. 95 (2005) 1550-1562]. Over-expression of DA receptors has

> been attributed to a compensatory mechanism resulting from

impairment in

> DA neurotransmitter production, storage and processing. In

conclusion,

> DHA is a versatile molecule with a wide range of actions spanning

from

> participation in cellular oxidative processes and intracellular

> signaling to modulatory roles in gene expression and growth

regulation.

>

> PMID: 16839753 [PubMed - indexed for MEDLINE]

>