Ghrelin

[Guest guest]

PSSD is caused by a disturbance in the release of Orexin and grehlin.

SSRI's cause a disturbance in grehlin

http://www.anxietyinsights.info/abstract__ssris_decrease_ghrelins_effe

ct_on_memory_retention.htm

Greater levels of Orexin are produced after you have suffered from

sleep deprivation (but only after you have had a few hours sleep to

recover from the sleep deprivation).

Greater levels of erexine are produced when you have been fasting and

have not eaten any food for a long time.

Greater levels of orexine are produced when you exercise.

Taking too much zinc can lower orexitine.

Orexine's main function seems to be to promote wakefulness. People

with low orexine may have symptoms of narcolepsy.

Orexine neurons also strongly excite the following neurons:

Dopamine, neuropipheramine, histamine, acetylcholine (as we always

expected).

Orexine makes you feel awake and energetic. If you have too little

orexine you will constantly self medicate with things like caffeine

etc, and also you will have some form of disturbances in your sleep

patterns.

Orexine increases cravings for food: It is closely linked to another

protein called grehlin. Grehlin is the hormone that makes you feel

hungry.

If you have low levels of grehlin you will not feel hungry very

often. Grehlin also causes nitric oxide synthase. Nitric oxide

synthase causes smooth muslce relaxation that allows erections to

take place.

If you go for 24 hours without sleep, don't each much food, and do a

few sit ups, and then sleep for 8 hours, you will see that when you

wake up you have an almost uncanny ability to get erections like you

used to do, feelings of energy and excitement come back to normal,

fantisies return to normal, appetite returns to normal, muscle pains

return to normal.

It is very difficult to stimulate the response of the dopamine,

neuropipheramine, histamine, acetylcholine properly without

increasing levels of orexine.

One drug that may increase levels of orexine is modafinil.

I would like to know more about G proteins and how they are formed,

does anyone know? If we can produce more G proteins?

There is a drug that agonises grehlin called TZP-101 (tranzyme). Has

anyone tried it? That would cure pssd I'm sure. I can't work out if

it was even allowed for release. But I think the FDA have cleared it.

http://www.datamonitor.com/industries/news/article/?pid=BFE7F717-A996-

4DA5-9ABF-7A58B00CFA75 & type=NewsWire