The association of RA & treatment w/ sinus disease...........

December 11, 2006

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1: J Rheumatol. 2006 Dec;33(12):2412-5.Related Articles, Links

The association of rheumatoid arthritis and its treatment with sinus disease.

Michaud K, Wolfe F.

OBJECTIVE: To determine if rates of sinus disease are increased in patients with

rheumatoid arthritis (RA) and whether RA treatment alters the risk of sinus

disease. METHODS: As part of a longitudinal study of rheumatic disease outcomes,

7,243 patients with RA, 1,667 with osteoarthritis (OA), and 447 with

fibromyalgia (FM) were evaluated for important sinus problems in 2003. We

defined an important sinus problem as one that required a physician visit.

RESULTS: The lifetime prevalence of sinus disorders among all patients was

42.9%. During the previous 6 months 22.3% of patients with RA, 23.9% with OA,

and 25.1% with FM visited a physician for a sinus problem and 22.4%, 23.9%, and

25.1% , respectively, received a prescription medication for a sinus problem.

After adjustment for age and sex, the rate of physician visits for a sinus

problem was significantly lower for patients with RA (22.1%) compared to

patients with OA (24.8%). The strongest predictor of sinus problems among all

patients was a history of allergy or asthma. Sinus problems were more common

among users of etanercept: odds ratio (OR) 1.2; 95% confidence interval (CI):

1.0-1.4 univariably, and OR 1.2; 95% CI: 1.0-1.4 multivariably. Sulfasalazine

(OR 0.7; 95% CI: 0.5-0.9) and leflunomide (OR 0.8; 95% CI: 0.7-1.0) had a

protective effect on sinus problems. CONCLUSIONS: Sinus problems are decreased

in patients with RA compared to OA and FM. Slight protective effects on sinus

problems are noted with sulfasalazine and leflunomide, and a slight increase in

risk of sinus problems is noted with etanercept.

PMID: 17143978 [PubMed - in process]