Re: Tumuric is possbility for PSSD depresion

[Guest guest]

It may be of interest to you that I had a test at a sleep study.

Sleep Apnea runs in my family, and since I've been sleepy for the last

6 years or so, we thought we'd give it a try.

I had a hard time falling asleep with all those wires and stuff, plus

I'd been sick and was rather nervous. But I did get aboout 3 hours of

sleep.

I didn't think this would be enough to determine anything, but when we

got the test results I learned that was not so. According to my

doctor, I went through all the major cycles of sleep in those 3 hours

and everything looked normal. So I don't know if that sheds any light

on your theory or not.

However, the doctor still half suspected some form of narcolepsy. We

had planned to do a narcolepsy test the next day, but couldn't because

an 8-hour sleep study is a prerequisite and I only got 3.

I don't have very many of the indications for narcolepsy - I don't

have uncontrollable " sleep attacks " and I don't have cataplexy. From

what I understand narcolepsy doesn't really affect libido, although

some have reported that Xyrem, one of the drugs for it, increased

their libido. What I DO have is a lot of excessive daytime sleepiness,

resistable sleep attacks, and a propensity to dream during short naps.

the last seemed to particularly interest my doctor, but the only way

to truly diagnose it is with that test.

The daytime test is almost 2 grand, and the night time one before it

is about the same. So I'd have to spend at least 4 grand, and while I

can usually sleep anywhere anytime, I couldn't seem to do it that

night with all those wires and people watching. So even if I spent

another 2 grand on another try, I might not make it that night or the

following day...

We did a blood test that looks for a gene associate with narcolepsy,

but that is not a sure thing one way or the other (while many people

with narcolepsy have it, some don't). Still, I didn't have the gene.

Narcolepsy is treated with the kind of drug you're talking about,

though... I think. Interestingly, amphetamines are something that some

of the PSSD people have had some success with.

--

>

> I've been trying tumeric for depression/lethargy and tiredness.

>

> The good thing about this drug is that it interacts with the 5ht1a,

> 5ht1b and 5ht2c repeptors. This should help to reduce slow wave sleep

> and deep sleep, and increease wakefullness. The other thing it does is

> increases serotonin and dopamine (obviously increasing wakefullness).

>

> I think really the root cause of pssd is that serotonin receptors in

> the dorsal raphe and or hypothalumus do not work properly, causing too

> much slow wave sleep, loss of dreams, poor REM sleep, lack of

> wakefullness. In the long run, this could effect the hypothalumus

> sleep/wake switch causing reductions in dopamine, cortisol,

> testosterone, oxytocin, poor neurotransmission at 5ht2a, 5ht2c, a1

> sites, and lack of nitric oxide. I believe that this is why very severe

> sleep deprivation temporarily cures all aspects of pssd.

>

> I'm not sure whether tumeric would help with this or not, for instance,

> will it pass the blood brain barrier?

>

[Guest guest]

Can you tell me more about tumeric? It looks like it's just some

Indian herb or something. What is it typically used for and where do

you get it?

>

> I've been trying tumeric for depression/lethargy and tiredness.

>

> The good thing about this drug is that it interacts with the 5ht1a,

> 5ht1b and 5ht2c repeptors. This should help to reduce slow wave sleep

> and deep sleep, and increease wakefullness. The other thing it does is

> increases serotonin and dopamine (obviously increasing wakefullness).

>

> I think really the root cause of pssd is that serotonin receptors in

> the dorsal raphe and or hypothalumus do not work properly, causing too

> much slow wave sleep, loss of dreams, poor REM sleep, lack of

> wakefullness. In the long run, this could effect the hypothalumus

> sleep/wake switch causing reductions in dopamine, cortisol,

> testosterone, oxytocin, poor neurotransmission at 5ht2a, 5ht2c, a1

> sites, and lack of nitric oxide. I believe that this is why very severe

> sleep deprivation temporarily cures all aspects of pssd.

>

> I'm not sure whether tumeric would help with this or not, for instance,

> will it pass the blood brain barrier?

>

[Guest guest]

It is used in curries, so you should be able to get it in the

supermarket or online. The main properties are neuroprotective. it

helps to build new neurons and also protects the brain from oxidative

stress. It is also an antidepressant. Obviously I would not promise

any miracles overnight. I would suggest mixing it with somethign that

increases nitric oxide a bit, such as caffeine, as otherwise your No

levels will drop.

> >

> > I've been trying tumeric for depression/lethargy and tiredness.

> >

> > The good thing about this drug is that it interacts with the

5ht1a,

> > 5ht1b and 5ht2c repeptors. This should help to reduce slow wave

sleep

> > and deep sleep, and increease wakefullness. The other thing it

does is

> > increases serotonin and dopamine (obviously increasing

wakefullness).

> >

> > I think really the root cause of pssd is that serotonin

receptors in

> > the dorsal raphe and or hypothalumus do not work properly,

causing too

> > much slow wave sleep, loss of dreams, poor REM sleep, lack of

> > wakefullness. In the long run, this could effect the hypothalumus

> > sleep/wake switch causing reductions in dopamine, cortisol,

> > testosterone, oxytocin, poor neurotransmission at 5ht2a, 5ht2c,

a1

> > sites, and lack of nitric oxide. I believe that this is why very

severe

> > sleep deprivation temporarily cures all aspects of pssd.

> >

> > I'm not sure whether tumeric would help with this or not, for

instance,

> > will it pass the blood brain barrier?

> >

>

[Guest guest]

Yes I have tried amphetamines. The information you have given me is

very usefull. Apart from going through all 3 major stages of sleep

were there any abnormalities? I have always thought that PSSD would

have some similarites to narcolepsy or EDS.

> >

> > I've been trying tumeric for depression/lethargy and tiredness.

> >

> > The good thing about this drug is that it interacts with the

5ht1a,

> > 5ht1b and 5ht2c repeptors. This should help to reduce slow wave

sleep

> > and deep sleep, and increease wakefullness. The other thing it

does is

> > increases serotonin and dopamine (obviously increasing

wakefullness).

> >

> > I think really the root cause of pssd is that serotonin

receptors in

> > the dorsal raphe and or hypothalumus do not work properly,

causing too

> > much slow wave sleep, loss of dreams, poor REM sleep, lack of

> > wakefullness. In the long run, this could effect the hypothalumus

> > sleep/wake switch causing reductions in dopamine, cortisol,

> > testosterone, oxytocin, poor neurotransmission at 5ht2a, 5ht2c,

a1

> > sites, and lack of nitric oxide. I believe that this is why very

severe

> > sleep deprivation temporarily cures all aspects of pssd.

> >

> > I'm not sure whether tumeric would help with this or not, for

instance,

> > will it pass the blood brain barrier?

> >

>

[Guest guest]

I was really hoping we would find some abnormalities in my sleep

study, but we didn't find any. The main thing we were looking for was

sleep apnea. I had a few minor apneas but nothing disruptive - the

same as what a normal person has.

I'm not an expert in how all the sleep cycles work, but the sleep

specialist doctor said I hit all the major cycles and that nothing

looked unusual.

Had we been able to do the narcolepsy test, I would have taken

monitored naps the next day to see how quickly I jumped into REM sleep

(I think). Apparently narcoleptics go straight into dream sleep or

REM or something. On my overnight study, though, nothing was unusual

about that, but I guess it takes the daytime study to really know for

sure. But that will probably never happen now. It would be a ton of

money for something that may not show anything IF I can even manage to

take the naps, and IF I managed to get 8 monitered hours the night

before... it's a lot of expensive IFs.

Have you seen any improvements with the tumeric? How long have you

been using it? Also which amphetamines did you try and did they do

anything for you?

--

> > >

> > > I've been trying tumeric for depression/lethargy and tiredness.

> > >

> > > The good thing about this drug is that it interacts with the

> 5ht1a,

> > > 5ht1b and 5ht2c repeptors. This should help to reduce slow wave

> sleep

> > > and deep sleep, and increease wakefullness. The other thing it

> does is

> > > increases serotonin and dopamine (obviously increasing

> wakefullness).

> > >

> > > I think really the root cause of pssd is that serotonin

> receptors in

> > > the dorsal raphe and or hypothalumus do not work properly,

> causing too

> > > much slow wave sleep, loss of dreams, poor REM sleep, lack of

> > > wakefullness. In the long run, this could effect the hypothalumus

> > > sleep/wake switch causing reductions in dopamine, cortisol,

> > > testosterone, oxytocin, poor neurotransmission at 5ht2a, 5ht2c,

> a1

> > > sites, and lack of nitric oxide. I believe that this is why very

> severe

> > > sleep deprivation temporarily cures all aspects of pssd.

> > >

> > > I'm not sure whether tumeric would help with this or not, for

> instance,

> > > will it pass the blood brain barrier?

> > >

> >

>

[Guest guest]

The truth is that sleep is primarily controlled by nitric oxide, and

neurotransmittors only play a sceondary role. I did not expect sleep

cycles to be " missed out " in people with PSSD, but what I would

expect is prolonged slow wave sleep, absence of dreams, and possibly

some changes in REM sleep.

I have tried phet yes, very strong stuff. I don't know what kind it

was, this stuff does not come with a label on it.

The only drug that really works for PSSD is ecstacy. Phet only makes

you feel really awake, less moody etc. it also brings back the

ability to cry (or perhaps this was intense exercise). Ecstacy brings

back erections completely, and also gets rid of genital numbness.

I would suggest cannibis over phet, because it improves your sleep

and wakefullness, and is probably better for libido.

The tumeric stuff is ok. Not very strong, but nevertheless good. It

has some effects on libido but hit and miss, better mixed with l-

argine and caffeine as it lowers nitric oxide otherwise.

If you want a drug that will actually work I think mCCP will be the

best thing.

http://labresearchsupply.com/buy-mcpp-1-3-chlorophenyl-piperazine-

dihydrochloride/

http://www.purebzp.com/html/buy_mcpp.html

> > > >

> > > > I've been trying tumeric for depression/lethargy and

tiredness.

> > > >

> > > > The good thing about this drug is that it interacts with the

> > 5ht1a,

> > > > 5ht1b and 5ht2c repeptors. This should help to reduce slow

wave

> > sleep

> > > > and deep sleep, and increease wakefullness. The other thing

it

> > does is

> > > > increases serotonin and dopamine (obviously increasing

> > wakefullness).

> > > >

> > > > I think really the root cause of pssd is that serotonin

> > receptors in

> > > > the dorsal raphe and or hypothalumus do not work properly,

> > causing too

> > > > much slow wave sleep, loss of dreams, poor REM sleep, lack of

> > > > wakefullness. In the long run, this could effect the

hypothalumus

> > > > sleep/wake switch causing reductions in dopamine, cortisol,

> > > > testosterone, oxytocin, poor neurotransmission at 5ht2a,

5ht2c,

> > a1

> > > > sites, and lack of nitric oxide. I believe that this is why

very

> > severe

> > > > sleep deprivation temporarily cures all aspects of pssd.

> > > >

> > > > I'm not sure whether tumeric would help with this or not, for

> > instance,

> > > > will it pass the blood brain barrier?

> > > >

> > >

> >

>