RESEARCH - Comparison of the effects of two antidepressants on exercise performance in fibromyalgia

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Clin Rheumatol. 2006 Jul;25(4):495-7. Epub 2005 Nov 3.

Comparison of the effects of two antidepressants on exercise performance of

the female patients with fibromyalgia.

Department of Physical Medicine and Rehabilitation, Faculty of Medicine,

Selcuk University, Meram, Konya, Turkey. ozerbil@...

OBJECTIVE: To compare the effects of two antidepressants on exercise

performance of the female patients with fibromyalgia. METHODS: Fifteen

patients with fibromyalgia participated in this randomized, double-blind

crossover study composed of two trials separated by a 2-week washout phase.

The pharmacy randomly assigned patients to two groups: (a) placebo (glucose)

in the morning and 25 mg amitriptyline at bedtime or ( 20 mg fluoxetine in

the morning and placebo at bedtime. The VO(2max) and Wingate anaerobic test

were evaluated. Within 24 h after 15-day medication, the tests were

repeated. RESULTS: Peak power and fatigue index increased, and VO(2max) and

VT did not change with both fluoxetine and amitriptyline. Mean power

significantly increased after fluoxetine but not after amitriptyline.

CONCLUSION: Both amitriptyline administration and fluoxetine administration

in patients with fibromyalgia have beneficial effects on anaerobic

performance. These effects may be important in life quality of the female

patients with fibromyalgia.

PMID: 16267603

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrieve & dopt=Abstra\

ctPlus & list_uids=16267603

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Mayo Clinic in Rochester

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s Hopkins Medicine

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