Guest guest Posted June 3, 2008 Report Share Posted June 3, 2008 I've been trying tumeric for depression/lethargy and tiredness. The good thing about this drug is that it interacts with the 5ht1a, 5ht1b and 5ht2c repeptors. This should help to reduce slow wave sleep and deep sleep, and increease wakefullness. The other thing it does is increases serotonin and dopamine (obviously increasing wakefullness). I think really the root cause of pssd is that serotonin receptors in the dorsal raphe and or hypothalumus do not work properly, causing too much slow wave sleep, loss of dreams, poor REM sleep, lack of wakefullness. In the long run, this could effect the hypothalumus sleep/wake switch causing reductions in dopamine, cortisol, testosterone, oxytocin, poor neurotransmission at 5ht2a, 5ht2c, a1 sites, and lack of nitric oxide. I believe that this is why very severe sleep deprivation temporarily cures all aspects of pssd. I'm not sure whether tumeric would help with this or not, for instance, will it pass the blood brain barrier? Quote Link to comment Share on other sites More sharing options...
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