RESEARCH - Anti-CCP versus anti-Sa antibodies in diagnosis of RA

[Guest guest]

J Rheumatol. 2006 Aug;33(8):1476-81.

Anti-Cyclic Citrullinated Peptide versus Anti-Sa Antibodies in Diagnosis of

Rheumatoid Arthritis in an Outpatient Clinic for Connective Tissue Disease

and Spondyloarthritis.

-Longo FJ, -Mahou M, -Ramon S, Estecha A, Balsera M,

Plaza R, Fernandez-Cruz E, LC.

From the Departments of Rheumatology, Immunology, and Experimental Medicine,

Hospital General Universitario Gregorio Maranon, Madrid, Spain.

OBJECTIVE: . To compare the diagnostic value of anti-cyclic citrullinated

peptide (anti-CCP) and anti-Sa antibodies in serum for prediction of

rheumatoid arthritis (RA) in an outpatient clinic for connective tissue

diseases and spondyloarthritides. METHODS: A cross-sectional study was

carried out to analyze the presence or absence of anti-CCP and anti-Sa

antibodies in the sera of 250 randomly selected patients. The disease

distribution in the study was as follows: 87 patients had RA (34.8%); 90

(36%) had other connective tissue diseases (CTD); 50 (20%)

spondyloarthritis; 19 (7.6%) polymyalgia rheumatica; and 4 (1.6%) juvenile

idiopathic arthritis. RESULTS: Anti-CCP antibodies were detected in 63

patients with RA and in 9 patients with other illnesses [sensitivity 72.4%,

specificity 94.4%, positive predictive value (PPV) 87.5%]. Anti-Sa

antibodies were detected in 38 patients with RA and in 6 patients with other

illnesses (sensitivity 43.6%, specificity 96.3%, PPV 86.3%). Anti-CCP and

anti-Sa results were discordant in up to 47 of 87 RA patients. No relation

between the presence of anti-Sa and higher or lower titers of anti-CCP

antibodies was observed.

CONCLUSION: The diagnostic value in RA is similar for both antibodies.

However, the sensitivity of anti-CCP detection is higher than that of

anti-Sa. Our results suggest that presence of anti-Sa antibodies in serum

may be useful as a complementary assay when anti-CCP antibodies are negative

and RA is suspected.

PMID: 16881106

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

6881106

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org