Guest guest Posted July 9, 2008 Report Share Posted July 9, 2008 what do you mean by normalizing?i was under the impression mdma raised serotonin levels and created a state of non-horniness (albeit euphoric)brentSubject: MDMA stimulates the prostateTo: SSRIsex Date: Tuesday, July 8, 2008, 5:27 PM I have been looking again at the effects of MDMA. When I was taking MDMA it had a miraculous effect at normalising the tissue in my testicles and penis. Something which i had not considered before was that it actually stimulates almost every neurotransmittor in the prostate, at the same time. The prostate is rich in M1 muscarinic receptors and alpha 2 receptors, as well as 5ht2 receptors. It also requires nitric oxide to elicit contractions. Furthermore, MDMA also increases oxytocin at the same time, which acts on the prostate to aid the transformation from testosterone to DHT. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 9, 2008 Report Share Posted July 9, 2008 Firstly, MDMA acts on pretty much the whole central nervous system, not just serotonin. -5HT receptors, dopamine, noradrenaline, M1 and M2 receptors, nitric oxide, oxytocin. It is closely related to amphetamine. Amphetamine also raises serotonin levels. Most of the drugs that have worked for PPSD raised serotonin levels. I expect that you have read lots of crap articles on wikipedia about how serotonin blocks sex drive completely and domamine enhances it. This is a huge oversimplification. Although I have taken MDMA several times and it completely stopped my PSSD for several days people are very willing to beleive that I am lying or wrong, mainly due to the huge amount of bad research around. The 5ht2C receptors are imporant for erections. Although 5ht1a receptors are not good for libido, they indirectly raise HPA axis and oxytocin, which also helps to comtrol the prostate and generate DHT from testosterone. Whats more, although MDMA is very similar to speed, it works a lot better interestingly. > > Subject: MDMA stimulates the prostate > To: SSRIsex > Date: Tuesday, July 8, 2008, 5:27 PM > > > > > > > > > > > > > > > > > > > I have been looking again at the effects of MDMA. When I was taking > > MDMA it had a miraculous effect at normalising the tissue in my > > testicles and penis. > > > > Something which i had not considered before was that it actually > > stimulates almost every neurotransmittor in the prostate, at the same > > time. > > > > The prostate is rich in M1 muscarinic receptors and alpha 2 receptors, > > as well as 5ht2 receptors. It also requires nitric oxide to elicit > > contractions. > > > > Furthermore, MDMA also increases oxytocin at the same time, which acts > > on the prostate to aid the transformation from testosterone to DHT. > Quote Link to comment Share on other sites More sharing options...
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