Guest guest Posted October 1, 2008 Report Share Posted October 1, 2008 Zinc status and serum testosterone levels of healthy adults. Prasad AS, Mantzoros CS, Beck FW, Hess JW, Brewer GJ. Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA. Zinc deficiency is prevalent throughout the world, including the USA. Severe and moderate deficiency of zinc is associated with hypogonadism in men. However, the effect of marginal zinc deficiency on serum testosterone concentration is not known. We studied the relationship between cellular zinc concentrations and serum testosterone cross-sectionally in 40 normal men, 20 to 80 y of age. In four normal young men (27.5 +/- 0.5 y), we measured serum testosterone before and during marginal zinc deficiency induced by restricting dietary zinc intake. We also measured serum testosterone in nine elderly men (64 +/- 9 y) who were marginally zinc deficient before and after 3 to 6 mo of supplementation with 459 mumol/ d oral zinc administered as zinc gluconate. Serum testosterone concentrations were significantly correlated with cellular zinc concentrations in the cross-sectional study (lymphocyte zinc versus serum testosterone, r = 0.43, p = 0.006; granulocyte zinc versus serum testosterone, r = 0.30, p = 0.03). Dietary zinc restriction in normal young men was associated with a significant decrease in serum testosterone concentrations after 20 weeks of zinc restriction (baseline versus post-zinc restriction mean +/- SD, 39.9 +/- 7.1 versus 10.6 +/- 3.6 nmol/L, respectively; p = 0.005). Zinc supplementation of marginally zinc-deficient normal elderly men for six months resulted in an increase in serum testosterone from 8.3 +/- 6.3 to 16.0 +/- 4.4 nmol/L (p = 0.02). We conclude that zinc may play an important role in modulating serum testosterone levels in normal men. PMID: 8875519 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/pubmed/8875519 "Testosterone, the most effective anabolic our bodies naturally produce, is known to be closely interrelated with zinc. Although much study still needs to be done, it appears that zinc, at the cellular level, may govern testosterone metabolism. It is also thought to control the metabolism of testosterone in the prostate, which is one of the organs most proliferant in zinc.A major indicator of this is in zinc's effects on male potency and sex drive. Moderate deficiency can lead to regression of the sex glands in men, and just a mild deficiency causes a low sperm count. (Zinc has been shown to be useful in the prevention and treatment of male infertility.) Low zinc levels are shown to lead to decreased sex drive, cause a loss of appetite and even emotional problems. Double blind studies have shown that supplemental zinc can increase blood levels of testosterone and the follicle-stimulating hormone in men with just very mildly deficient zinc levels -- and most people, when tested, are shown to be defficent. Trainers, let me repeat, males, with just mild zinc deficiency, will increase their plasma levels of testosterone with supplementation! This is a clearly proven medical fact! For about 25 cents a week you can take what may be the most powerful legal and natural 'anabolic' supplement. " http://staff.washington.edu/griffin/zinc.txt http://www.nutros.com/nsr-0202g.html http://www.advance-health.com/zinc.html If zinc is going to increase testosterone levels to those who need to, then 30 - 40mg per day for at least 4 - 6 months is required. Don't take more than 40mg per day of zinc as a high dose of zinc has the potential, after a few months, to speed up the thyroid causing symptoms of over-active thyroid. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 1, 2008 Report Share Posted October 1, 2008 I should add that I took zinc supplements in the past for several months but it had no effect on my PSSD because, unbeknown to me at the time, my testosterone levels were within the normal reference ranges. > > Zinc status and serum testosterone levels of healthy adults. Prasad AS > <http://www.ncbi.nlm.nih.gov/sites/entrez? Db=pubmed & Cmd=Search & Term=%22P\ > rasad%20AS%22%5BAuthor% 5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Resu\ > ltsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus> , Mantzoros CS > <http://www.ncbi.nlm.nih.gov/sites/entrez? Db=pubmed & Cmd=Search & Term=%22M\ > antzoros%20CS%22%5BAuthor% 5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_R\ > esultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus> , Beck FW > <http://www.ncbi.nlm.nih.gov/sites/entrez? Db=pubmed & Cmd=Search & Term=%22B\ > eck%20FW%22%5BAuthor% 5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Result\ > sPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus> , Hess JW > <http://www.ncbi.nlm.nih.gov/sites/entrez? Db=pubmed & Cmd=Search & Term=%22H\ > ess%20JW%22%5BAuthor% 5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Result\ > sPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus> , Brewer GJ > <http://www.ncbi.nlm.nih.gov/sites/entrez? Db=pubmed & Cmd=Search & Term=%22B\ > rewer%20GJ%22%5BAuthor% 5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Resu\ > ltsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus> . > Department of Internal Medicine, Wayne State University School of > Medicine, Detroit, Michigan, USA. > > Zinc deficiency is prevalent throughout the world, including the USA. > Severe and moderate deficiency of zinc is associated with hypogonadism > in men. However, the effect of marginal zinc deficiency on serum > testosterone concentration is not known. We studied the relationship > between cellular zinc concentrations and serum testosterone > cross-sectionally in 40 normal men, 20 to 80 y of age. In four normal > young men (27.5 +/- 0.5 y), we measured serum testosterone before and > during marginal zinc deficiency induced by restricting dietary zinc > intake. We also measured serum testosterone in nine elderly men (64 +/- > 9 y) who were marginally zinc deficient before and after 3 to 6 mo of > supplementation with 459 mumol/ d oral zinc administered as zinc > gluconate. Serum testosterone concentrations were significantly > correlated with cellular zinc concentrations in the cross-sectional > study (lymphocyte zinc versus serum testosterone, r = 0.43, p = 0.006; > granulocyte zinc versus serum testosterone, r = 0.30, p = 0.03). Dietary > zinc restriction in normal young men was associated with a significant > decrease in serum testosterone concentrations after 20 weeks of zinc > restriction (baseline versus post-zinc restriction mean +/- SD, 39.9 +/- > 7.1 versus 10.6 +/- 3.6 nmol/L, respectively; p = 0.005). Zinc > supplementation of marginally zinc-deficient normal elderly men for six > months resulted in an increase in serum testosterone from 8.3 +/- 6.3 to > 16.0 +/- 4.4 nmol/L (p = 0.02). We conclude that zinc may play an > important role in modulating serum testosterone levels in normal men. > > PMID: 8875519 [PubMed - indexed for MEDLINE] > > http://www.ncbi.nlm.nih.gov/pubmed/8875519 > <http://www.ncbi.nlm.nih.gov/pubmed/8875519> > > > > " Testosterone, the most effective anabolic our bodies naturally produce, > is known to be closely interrelated with zinc. Although much study still > needs to be done, it appears that zinc, at the cellular level, may > govern testosterone metabolism. It is also thought to control the > metabolism of testosterone in the prostate, which is one of the organs > most proliferant in zinc. > > A major indicator of this is in zinc's effects on male potency and sex > drive. Moderate deficiency can lead to regression of the sex glands in > men, and just a mild deficiency causes a low sperm count. (Zinc has been > shown to be useful in the prevention and treatment of male infertility.) > Low zinc levels are shown to lead to decreased sex drive, cause a loss > of appetite and even emotional problems. Double blind studies have shown > that supplemental zinc can increase blood levels of testosterone and the > follicle-stimulating hormone in men with just very mildly deficient zinc > levels -- and most people, when tested, are shown to be defficent. > Trainers, let me repeat, males, with just mild zinc deficiency, will > increase their plasma levels of testosterone with supplementation! This > is a clearly proven medical fact! For about 25 cents a week you can take > what may be the most powerful legal and natural 'anabolic' supplement. " > > http://staff.washington.edu/griffin/zinc.txt > <http://staff.washington.edu/griffin/zinc.txt> > > http://www.nutros.com/nsr-0202g.html > <http://www.nutros.com/nsr-0202g.html> > > http://www.advance-health.com/zinc.html > <http://www.advance-health.com/zinc.html> > > If zinc is going to increase testosterone levels to those who need to, > then 30 - 40mg per day for at least 4 - 6 months is required. Don't take > more than 40mg per day of zinc as a high dose of zinc has the potential, > after a few months, to speed up the thyroid causing symptoms of > over-active thyroid. > Quote Link to comment Share on other sites More sharing options...
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