5HT1A /B Antagonists

[Guest guest]

I want to start a new thread that focuses on 5HT1A/B receptor

blockade, because I think this is where our problem and solution

ultimately lie.

From the scientific abstracts I've read on the internet, SSRI's

downregulate 5HT1A postsynaptic receptors -among others- and that the

use of 5HT1A antagonists can restore receptor sensitivity/density.

The problem we face is: What medication can we reasonably ask for that

will help our situation? Most 5HT1A antagonists are found in a class

of psych meds called neuroleptics or antipsychotic, antischizphrenic

drugs which usually have associated dopamine antagonist properties.

It may be difficult for a patient suffering from SSRI induced sexual

dysfunction to ask for Spiperone or Chlorpromazine as simply an

adjuvant to or remedy for SSRI.

I'm hoping that one of us will soon find such an agent.

I already know Nefazodone works so-so for this problem, but it has

problems due to adrenoreceptor antagonism and very slight chance of

liver toxicity.

I should also post a retraction about Yohimbine HCL. According to

Wikipedia it IS classified as a 5HT1A/B Antagonist, but there is no

citation for this. When I Googled Yohimbine HCL on the internet, I

find that Yohimbine HCL is only listed as a 5HT1A/B agonist, so now

I'm not sure what to believe, but I apologize for passing along what

could be incorrect info from Wikipedia. I felt some improvement from

Yohimbine, but now I'm thinking it was entirely from the

norepinepherine increase.

In past posts, people have brought up MDMA as a possibility, but I

just don't see that or Nefazodone for that matter as long term

solutions or cures. MDMA is similar to amphetamine in that it boosts

SERT /5HTT and oxytocin. In the short term, this increase in

catecholamines may give you a feeling of heightened libido as does

methylphenidate or adderall, but they may ultimately further down

regulate our already marginal 5HT1A receptors causing even less

sensitivity.

Vornan, have you tried any sort of 5HT1 antagonist?

C