Re: Re: Crohn's Disease and mold

[Guest guest]

Cassidy,

I am not a physician, but I can answer that question. Autoimmune diseases are Type III Hypersensitivity Reactions. One of the more serious illnesses that people experience after excessive mold exposure, is Hypersensitivity Pneumonitis (HP). It to, is a Type III Hypersensitivity Reaction. In its advanced stages, the symptoms of HP are similar to many other Type III, autoimmune reactions.

That's why you see so many mold victims being tested for the HIV virus which causes AIDS. What is AIDS? It is an acquired immune deficiency with a variety of symptoms similar to many autoimmune diseases or advanced HP brought on by excessive mold exposure.

Basically, I think it would be correct to say, all are conditions that cause the body trouble because of the excessive increase in antibody production while trying to fight off whatever the antigen is. The term autoimmune disease implies the body is turning on itself. But, the evidence that illnesses such as Crohns, MS, Lupus, etc are actually environmentally induced illnesses is becoming stronger everyday. With mold, it is a given what is the antigen that is forcing the over production of antibodies.

Sharon

To any Docs or Immunologists in the group:Crohn's disease is an autoimmune disease resulting fromself-recognizing antibodies - as is rheumatoid arthritis.How has (or is) the research connected autoimmune disease to increasedand persistant antibody generation by atopic individuals who arecontinually exposed to an allergen?Cassidy Kuchenbeckers Engineering

[Guest guest]

Sharon, Be very very careful with making such sweeping generalisations and associations especially when you state that you are not a physician. Unless you know for certain that the biochemical process and clinical progression for each disease is the same then it verges on irresponsibility to make such statements. It is akin to saying that the cold and the flu are the same because they are both caused by viruses. They are not the same. They have completely different causes. And medically they have different treatments and outcomes depending on the individual affected. You just posted articles on lapses in scientific ethics in academia. So why is it ok for you to answer questions in which you are not qualified? When you require others to hold high standards of behaviour it would be fitting for you to do the same. No? Stuart McCallum ---------------------------------------------------------------------------------------------------------------------------- Message: 9 Date: Fri, 14 Apr 2006 20:46:07 EDT From: snk1955@...Subject: Re: Re: Crohn's Disease and mold Cassidy, I am not a physician, but I can answer that question. Autoimmune diseases are Type III Hypersensitivity Reactions. One of the more serious illnesses that people experience after excessive mold exposure, is Hypersensitivity Pneumonitis (HP). It to, is a Type III Hypersensitivity Reaction. In its advanced stages, the symptoms of HP are similar to many other Type III,

autoimmune reactions. That's why you see so many mold victims being tested for the HIV virus which causes AIDS. What is AIDS? It is an acquired immune deficiency with a variety of symptoms similar to many autoimmune diseases or advanced HP brought on by excessive mold exposure. Basically, I think it would be correct to say, all are conditions that cause the body trouble because of the excessive increase in antibody production while trying to fight off whatever the antigen is. The term autoimmune disease implies the body is turning on itself. But, the evidence that illnesses such as Crohns, MS, Lupus, etc are actually environmentally induced illnesses is becoming stronger everyday. With mold, it is a given what is the antigen that is forcing the over production of antibodies.

Sharon

[Guest guest]

Thank you, Tony! Just the little bit that you were able to share of that document appears to me to be something that could really help move the science forward.

Sharon

[Guest guest]

It is not mine to share in that fashion although we (pH2) paid for it. This was from a piece we (pH2) hired him to prepare for some work in California. I had hired him to review a report on a set of asthma cases as well .

[Definition of Compentency - knowing your business well enough to have a very very low rate of failure; knowing enough about what you don't know and being willing to either a) decline the work or find someone who can do it competently]

I will be talking with Dr. s today (on another review) and will see if he has a chapter in a book or an article that might be available for release.

He and others did a wonderful session on "Management of Type I Respiratory Allergens" at the AIHA Conference in 1998. I have it on tape; it may still be available through AIHA. s did a review from which this was a part (mr. First intro to him). Other speakers included industry experts for P & G and other enzyme producers and on maleic anhydride. The production and history of enzymes in the detergent industry (late 1960s - a lot of Type I Respiratory sensitization to subtilisins from B. subtilis) and similar enzymes today was excellent. Dealt with peak dose, sampling problems, low level limits (ng/m^3), mouse models and verification with other agents besides subtilisins. Best summary I've come across.

As a side note, one of the Protor and Gamble PhDs from that era of model production is now at NIOSH - unfortunately they have no money to produce the review necessary. I'll be speaking with him later this week and will give an update if any.

Tony

........................................................................... "Tony" Havics, CHMM, CIH, PEpH2, LLCPO Box 34140Indianapolis, IN 46234 cell90% of Risk Management is knowing where to place the decimal point...any consultant can give you the other 10%â„ This message is from pH2. This message and any attachments may contain legally privileged or confidential information, and are intended only for the individual or entity identified above as the addressee. If you are not the addressee, or if this message has been addressed to you in error, you are not authorized to read, copy, or distribute this message and any attachments, and we ask that you please delete this message and attachments (including all copies) and notify the sender by return e-mail or by phone at . Delivery of this message and any attachments to any person other than the intended recipient(s) is not intended in any way to waive confidentiality or a privilege. All personal messages express views only of the sender, which are not to be attributed to pH2 and may not be copied or distributed without this statement.

-----Original Message-----From: iequality [mailto:iequality ] On Behalf Of snk1955@...Sent: Saturday, April 15, 2006 2:58 PMTo: iequality Subject: Re: Re: Crohn's Disease and mold

Sharon,

You stated" I am not a physician, but I can answer that question. Autoimmune diseases are Type III Hypersensitivity Reactions. One of the more serious illnesses that people experience after excessive mold exposure, is Hypersensitivity Pneumonitis (HP). It to, is a Type III Hypersensitivity Reaction. In its advanced stages, the symptoms of HP are similar to many other Type III, autoimmune reactions

Tony,

Wow! Can you share the rest of that document?

At the risk of being jumped for not having a medical degree, yet stating my understanding of the matter, I am speaking primarily of non-IgE mediated illnesses from mold and mycotoxin exposure. This would include IgG and IgM responses from an immunological standpoint along with symptoms indicative of colonization within various organs.

Also physical responses from a toxicity standpoint indicative more of a poisoning effect from the mycotoxins, endotoxins, etc, as opposed to the molds themselves.

Also, in my humble opinion, there is a genetic factor that plays into the propencity for serious illnesses as a result of excessive mold and mycotoxin exposure (and endotoxins, etc) that do not go away simply by removing one from the moldy environment. Just as there is a currently undetermined genetic propensity for some autoimmune diseases.

So is it a classic Type III hypersensitivity response? I think that it very well could be. And that many illnesses that are currently chalked up to inflamation associated with autoimmune response, are in reality simply the body fighting very hard against an antigen of unknown etiology - that current medical testings are not able to establish.

But let me state again: I am not a doctor. I am not a doctor. I am not a doctor. Please don't jump me for simply stating my understanding of the matter.

Sharon