RESEARCH - Specific antinuclear antibodies are associated with clinical features in SLE

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Ann Rheum Dis. 2004 Sep;63(9):1155-8.

Specific antinuclear antibodies are associated with clinical features in

systemic lupus erythematosus.

Hoffman IE, Peene I, Meheus L, Huizinga TW, Cebecauer L, Isenberg D, De

Bosschere K, Hulstaert F, Veys EM, De Keyser F.

Department of Rheumatology, Ghent University Hospital, Ghent, Belgium.

Ilse.Hoffman@...

OBJECTIVES: To study associations between antinuclear antibodies (ANA) and

signs/symptoms in patients with systemic lupus erythematosus (SLE). METHODS:

A consecutive cohort of 289 patients with SLE was included; 235 fulfilled

ACR criteria for SLE and were further analysed. ANA profiles were determined

by line immunoassay and by indirect immunofluorescence on Crithidia

luciliae. An extensive list of signs/symptoms was evaluated. RESULTS: Five

clusters of antibodies were defined by cluster analysis: 1-antibodies to

SmB, SmD, RNP-A, RNP-C, and RNP-70k; 2-antibodies to Ro52, Ro60, and SSB; 3,

4, and 5-antibodies to ribosomal P, histones and dsDNA, respectively.

Significant associations (p< or =0.01) were found between anti-RNP-70k,

anti-RNP-A, anti-RNP-C and Raynaud's phenomenon, between anti-RNP-A,

anti-RNP-70k and leucopenia, and between anti-RNP-A, anti-RNP-C and a lower

prevalence of urine cellular casts. Anti-SSA, anti-SSB were associated with

xerostomia, and anti-SSB with pericarditis. Antibodies to ribosomal P were

associated with haemolytic anaemia, leucopenia, and alopecia. Patients with

anti-dsDNA antibodies had a higher risk for cellular casts and a lower risk

for photosensitivity. Antihistone antibodies were associated with arthritis.

CONCLUSIONS: In a large and consecutive cohort of patients with SLE,

clusters of antibodies were identified. Previously reported associations of

antibodies with symptoms were confirmed and new associations found.

PMID: 15308527

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=15308527

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