RESEARCH - Antibodies to centromere proteins in primary Sjogren's syndrome compared with limited scleroderma

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Ann Rheum Dis. 2006 Aug;65(8):1028-32. Epub 2006 Jan 13.

Distinct recognition of antibodies to centromere proteins in primary

Sjogren's syndrome compared with limited scleroderma.

Gelber AC, Pillemer SR, Baum BJ, Wigley FM, Hummers LK, S, Rosen A,

Casciola-Rosen L.

s Hopkins University School of Medicine, 5200 Eastern Avenue, Mason F

Lord Building Center Tower, Suite 4100, Room 407, Baltimore MD 21224, USA.

agelber@...

BACKGROUND: Anticentromere antibodies are characteristically observed in

scleroderma but have recently been reported in other autoimmune rheumatic

disorders, including Sjogren's syndrome. It is not known whether distinct

centromere proteins (CENP) are targeted in primary Sjogren's syndrome (pSS)

and scleroderma. OBJECTIVE: To determine whether antibodies to CENP-B and

CENP-C are present in these two disorders. METHODS: Sera from 45 patients

with pSS and 33 with limited scleroderma were studied. All patients met

classification criteria for pSS and scleroderma, respectively. Sera were

used to immunoprecipitate in vitro translated CENP-B and CENP-C. The

proportions recognising CENP-B or CENP-C were compared. RESULTS: 10 of 45

patients (22%) with pSS and 18 of 33 (55%) with scleroderma had antibodies

recognising CENPs (p = 0.004). Seven of 10 (70%) CENP positive patients with

pSS recognised CENP-C alone, compared with one of 18 (6%) CENP positive

patients with scleroderma (odds ratio (OR) = 40 (95% confidence interval

(CI), 3.5 to 450) (p = 0.003). In contrast, the majority (15 of 18 (83%)) of

CENP positive scleroderma sera recognised both CENP-B and CENP-C, compared

with none of 10 pSS sera (OR = 93 (95% CI, 4.4 to 1979) (p = 0.0001).

CONCLUSIONS: The pattern of CENP recognition differs markedly in pSS and

limited scleroderma. While patients with pSS predominantly recognise CENP-C

alone, dual recognition of CENP-B and CENP-C is most frequent in

scleroderma. These findings suggest that obtaining antibodies to specific

centromere antigens is useful diagnostically, and imply that distinct

mechanisms underlie the unique patterns of centromere autoreactivity in pSS

and scleroderma.

PMID: 16414973

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

6414973

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