RESEARCH - Replication of association of IL1 gene complex members with ankylosing spondylitis

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Ann Rheum Dis. 2006 Aug;65(8):1106-9. Epub 2005 Dec 16.

Replication of association of IL1 gene complex members with ankylosing

spondylitis in Taiwanese Chinese.

Chou CT, Timms AE, Wei JC, Tsai WC, Wordsworth BP, Brown MA.

Centre for Immunology and Cancer Research, Princess andra Hospital,

Ipswich Road, Woolloongabba, Queensland 4102, Australia.

OBJECTIVE: To test the association of interleukin 1 (IL1) gene family

members with ankylosing spondylitis (AS), previously reported in Europid

subjects, in an ethnically remote population. METHODS: 200 Taiwanese Chinese

AS patients and 200 ethnically matched healthy controls were genotyped for

five single nucleotide polymorphisms (SNPs) and the IL1RN.VNTR, markers

previously associated with AS. Allele, genotype, and haplotype frequencies

were compared between cases and controls. RESULTS: Association of alleles

and genotypes of the markers IL1F10.3, IL1RN.4, and IL1RN.VNTR was observed

with AS (p<0.05). Haplotypes of pairs of these markers and of the markers

IL1RN.6/1 and IL1RN.6/2 were also significantly associated with AS. The

strongest associations observed were with the marker IL1RN.4, and with the

two-marker haplotype IL1RN.4-IL1RN.VNTR (both p = 0.004). Strong linkage

disequilibrium was observed between all marker pairs except those involving

IL1B-511 (D' 0.4 to 0.9, p<0.01).

CONCLUSIONS: The IL1 gene cluster is associated with AS in Taiwanese

Chinese. This finding provides strong statistical support that the

previously observed association of this gene cluster with AS is a true

positive finding. These authors contributed equally to the study.

PMID: 16361275

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

6361275

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