Re: running in the family-- genetic hereditary rule of thumb--

[Guest guest]

The " skip one generation " thing is rather simple:

Definitions:

An allele: is an alternative form of a gene located at a particular chromosome

site. In simpler words, it is a little thing that is a component of a

chromosome; and a chromosome is the thing that contains the hereditary stuff.

In order for someone to have any genetic disease, one must inherit 2 flawed

alleles, one from each parent. If a parent only has one flawed allele, that

person will be a carrier of the disease but will not have it. When a carrier has

a child with another carrier of the same disease, that child is likely [not

necessarily] to inherit the 2 flawed alleles, one from each parent then that

child will have the disease.

Sue <marysue@...> wrote:

I figure that I caught most of the diseases in my family (diabetes, RA,

and Fuchs' corneal dystrophy). I'm hoping that they will at least skip

a generation, as some genetic things seem to. Neither of my parents was

ever diagnosed with diabetes, RA or any other auto-immune disease, or

Fuchs' dystrophy. But in looking back, I'm sure that my father had the

Fuchs' since he had the same symptoms that I'm having.

Sue

On Thursday, May 18, 2006, at 11:31 PM, Kathe Sabetzadeh wrote:

> I definately agree with and about their

> being some sort of trigger response that brings on

> autoimmune diseases in individuals, family based or

> not. Just wish I could have disabled my trigger

> before the autoimmune gun fired! Someday hopefully

> research will be able to find that trigger in time to

> save generations to come, including our children and

> grandchildren.

[Guest guest]

Well, yes and no, .

For example, this isn't true for sex-linked diseases such as hemophilia. The

mother alone can be the carrier. And then usually only her male offspring

passed the gene for hemophilia will develop a severe form of the disease. If

the female offspring get the gene (from only their mother), they will more

likely be carriers only.

And, in the case of RA, it's unlikely that only one gene is responsible for

conferring susceptibility.

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

Re: [ ] running in the family-- genetic hereditary rule of

thumb--

> The " skip one generation " thing is rather simple:

>

> Definitions:

> An allele: is an alternative form of a gene located at a particular

> chromosome site. In simpler words, it is a little thing that is a

> component of a chromosome; and a chromosome is the thing that contains the

> hereditary stuff.

>

> In order for someone to have any genetic disease, one must inherit 2

> flawed alleles, one from each parent. If a parent only has one flawed

> allele, that person will be a carrier of the disease but will not have it.

> When a carrier has a child with another carrier of the same disease, that

> child is likely [not necessarily] to inherit the 2 flawed alleles, one

> from each parent then that child will have the disease.

>

>