RESEARCH - What are effective medication combinations for dyslipidemia?

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J Fam Pract. 2006 Jan;55(1):70-2.

What are effective medication combinations for dyslipidemia?

Saseen J, Tweed E, Crawford P.

University of Colorado at Denver and Health Sciences Center, Denver, CO USA.

Many combination drug therapies are effective in treating dyslipidemia.

Compared with statin monotherapy, combinations that include ezetimibe

(Zetia), a bile acid sequestrant, or niacin further lower low-density

lipoprotein (LDL) cholesterol (strength of recommendation [sOR]: A), and

increase the likelihood of attaining National Cholesterol Education Program

(NCEP) LDL cholesterol goals (SOR: . Adding ezetimibe to a bile acid

sequestrant reduces LDL cholesterol (SOR: . Fibrate or niacin added to

statin monotherapy provide mixed lipid-modifying effects for combined

dyslipidemia (SOR: A). Most combination therapies increase the risk of

intolerance or side effects, including myopathy. The statin/gemfibrozil

combination has the highest risk of myopathy, whereas statin/ezetimibe or

statin/bile acid sequestrant have the least increased risk (SOR: . Studies

evaluating patient-oriented outcomes (morbidity, mortality) with combination

therapy vs monotherapy have not yet been conducted; however, combination

therapies have demonstrated reduced atherosclerotic lesion progression. .

PMID: 16388773

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=16388773 & itool=iconabstr & query_hl=7 & itool=pubmed_DocSum

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Mayo Clinic in Rochester

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s Hopkins Medicine

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