RESEARCH - Anti-inflammatory cytokines in gingival crevicular fluid in patients with periodontitis and RA

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Cytokine. 2006 Aug;35(3-4):180-5. Epub 2006 Sep 18.

Anti-inflammatory cytokines in gingival crevicular fluid in patients with

periodontitis and rheumatoid arthritis: a preliminary report.

Suleyman Demirel University, Faculty of Dentistry, Department of

Periodontology, Isparta, Turkey.

Cytokines which are produced by host cells play an important role in

pathogenesis both rheumatoid arthritis (RA) and chronic periodontitis (CP).

In this study, we aim to investigate the levels of Interleukin (IL)-4 and

IL-10 in gingival crevicular fluid (GCF). Seventeen patients with CP, 17

patients with RA and 17 healthy controls (HC) were included. The RA group

was divided into two groups according to gingival sulcus depths (RA-a: PD <

or =3mm, (n=12), RA-b: PD>3mm, (n=5)). For each patient, clinical parameters

were recorded. The GCF samples were evaluated by enzyme-linked immunosorbent

assay (ELISA) for IL-4 and IL-10 levels. IL-4 levels in the RA-a, RA-b and

CP subjects were significantly lower compared to the HC subjects (p<0.05).

The mean level of IL-4 in RA-b group was significantly higher than that in

CP group (p<0.05). IL-10 mean level in the HC group was higher than those in

the other groups (p<0.05). In the RA-a group, higher IL-10 level was found

compared to the CP patients (p<0.05). Within the limitations of this

preliminary report, it can be concluded that the initiation and progression

of periodontal inflammation may be due to a lack or inappropriate response

of the anti-inflammatory cytokines in both CP and RA.

PMID: 16982199

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