RESEARCH - Longitudinal analysis of gray and white matter loss in patients with SLE

[Guest guest]

Neuroimage. 2007 Jan 15;34(2):694-701. Epub 2006 Nov 16.

Longitudinal analysis of gray and white matter loss in patients with

systemic lupus erythematosus.

Rheumatology Unit, State University of Campinas, Brazil; Neuroimaging

Laboratory, State University of Campinas, Brazil.

Cerebral atrophy has been described to occur in systemic lupus erythematosus

(SLE) with variable frequency. The aim of this study was to determine white

and gray matter abnormalities in brain magnetic resonance imaging (MRI) of

patients with SLE and to determine if these abnormalities progress over a

one-year period. Seventy-five patients with SLE and 44 healthy age and

sex-matched controls were enrolled in this study. T1-weighted volumetric

images were used for voxel based morphometry (VBM) analyses. SLE patients

exhibited a significant reduction in white matter and gray matter volume

compared to controls (p=0.001). Follow-up images, after an average interval

of 19 months, revealed a progressive white matter and gray matter atrophy

(p=0.001). Reduced white and gray matter volume was associated with disease

duration and the presence of antiphospholipid antibodies. Patients with

severe cognitive impairment had a more pronounced white and gray matter

reduction than patients with moderate cognitive impairment. Total

corticosteroid dose was associated with gray matter reduction and not with

white matter loss in SLE patients. We concluded that brain tissue loss

associated with SLE is significant and progresses over a relatively short

period of time. Disease duration, the presence of antiphospholipid

antibodies and cognitive impairment were associated with white and gray

matter loss. Corticosteroid was associated only with gray matter atrophy.

PMID: 17112740

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrieve & dopt=Abstra\

ctPlus & list_uids=17112740

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[Guest guest]

URKK! How many times have I said " I've got half a mind to... "

Turns out I may have been right!

>

> Neuroimage. 2007 Jan 15;34(2):694-701. Epub 2006 Nov 16.

>

>

> Longitudinal analysis of gray and white matter loss in patients

with

> systemic lupus erythematosus.

>

>

> Rheumatology Unit, State University of Campinas, Brazil;

Neuroimaging

> Laboratory, State University of Campinas, Brazil.

>

>

> Cerebral atrophy has been described to occur in systemic lupus

erythematosus

> (SLE) with variable frequency. The aim of this study was to

determine white

> and gray matter abnormalities in brain magnetic resonance imaging

(MRI) of

> patients with SLE and to determine if these abnormalities progress

over a

> one-year period. Seventy-five patients with SLE and 44 healthy age

and

> sex-matched controls were enrolled in this study. T1-weighted

volumetric

> images were used for voxel based morphometry (VBM) analyses. SLE

patients

> exhibited a significant reduction in white matter and gray matter

volume

> compared to controls (p=0.001). Follow-up images, after an average

interval

> of 19 months, revealed a progressive white matter and gray matter

atrophy

> (p=0.001). Reduced white and gray matter volume was associated

with disease

> duration and the presence of antiphospholipid antibodies. Patients

with

> severe cognitive impairment had a more pronounced white and gray

matter

> reduction than patients with moderate cognitive impairment. Total

> corticosteroid dose was associated with gray matter reduction and

not with

> white matter loss in SLE patients. We concluded that brain tissue

loss

> associated with SLE is significant and progresses over a

relatively short

> period of time. Disease duration, the presence of antiphospholipid

> antibodies and cognitive impairment were associated with white and

gray

> matter loss. Corticosteroid was associated only with gray matter

atrophy.

>

>

> PMID: 17112740

>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

db=pubmed & cmd=Retrieve & dopt=AbstractPlus & list_uids=17112740

>

>

>

>

> Not an MD

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

>