CASE REPORTS - Neurological complications of Remicade

[Guest guest]

J Rheumatol. 2006 May;33(5):1018-20. Epub 2006 Mar 1.

Neurological complications of infliximab.

Jarand J, Zochodne DW, LO, Voll C.

Department of Medicine, University of Calgary, Calgary, Alberta T2N 4NI.

The use of anti-tumor necrosis factor-a (TNF-a) therapies has led to

improved outcomes in the treatment of rheumatoid arthritis (RA). However,

the use of these new therapeutic agents requires careful monitoring for

adverse effects. We describe 3 patients who developed neurological disease

closely associated with the use of infliximab, a monoclonal antibody that

binds to and inactivates TNF-a. All had evidence of polyneuropathy,

demyelinating in one and axonal in 2. One patient had a central nervous

system syndrome. Physicians should be aware of these potential adverse

effects when treating patients with infliximab.

PMID: 16511935

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

6511935

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org