RESEARCH - Ant-CCP antibodies in psoriatic patients with or without joint inflammation

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Ann Rheum Dis. 2006 Mar;65(3):398-400. Epub 2005 Aug 11.

Antibodies against cyclic citrullinated peptide (CCP) in psoriatic patients

with or without joint inflammation.

Department of Rheumatology, University Hospital, SE-901 85 Umea, Sweden.

gerdmarie.alenius@...

OBJECTIVE: To compare the prevalence of anti-CCP antibodies in psoriatic

patients with and without joint inflammation, patients with early RA, and

controls. METHODS: Anti-CCP antibodies (cut off level 5 U/ml) were measured

in 160 patients with psoriatic arthritis (PsA), 146 patients with psoriasis

but no arthritic disease, 101 patients with early RA, and 102 healthy

controls by ELISA. RESULTS: 11 (7%) patients with PsA, 75 (74%) patients

with early RA, 2 (2%) healthy controls (2%), and 1 (0.7%) patient with

psoriasis without arthritis had anti-CCP antibodies above the cut off level.

The presence of anti-CCP antibodies was not related to radiological changes

and/or deformity and functional impairment in PsA. 8/11 patients with PsA

and anti-CCP antibodies had a polyarthritic disease, and all fulfilled the

ACR criteria for RA at 4 year follow up. Five of these 8 patients also had

manifestations such as dactylitis, DIP involvement, radiological changes

associated with PsA, and/or enthesitis. In multiple logistic regression

analysis with polyarthritis as the dependent variable, anti-CCP antibodies

and rheumatoid factor significantly distinguished RA from PsA.

CONCLUSIONS:

Anti-CCP antibodies were more prevalent in patients with PsA than in

patients with psoriasis without arthritis, but less prevalent than in

patients with early RA. Patients with PsA positive for anti-CCP antibodies

more often had polyarthritic disease, but the presence of anti-CCP

antibodies did not relate to radiological changes and/or deformity and

functional impairment.

PMID: 16096328

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus & db=pubmed & cmd=R\

etrieve & dopt=abstractplus & list_uids=16096328

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