Guest guest Posted May 6, 2006 Report Share Posted May 6, 2006 , I've never taken it, but I've heard of it. It's an NSAID (non sterodial anti inflammatory drug) (like Celebrex) but usually used only for VERY short term because of potential side effects. I've cut and pasted below some info from Medline. I think you posted a question about Celebrex the other day too. I took it off and on for years for neck problems from a car accident, but stopped taking it when all the news broke about Celebrex and Vioxx causing heart and respiratory problems. I'm curious as to why your doc is trying so many different NSAIDs on you--wouldn't it make more sense to try a DMARD (disease modifying anti rheumatic drug) like methotrexate or an Anti-TNF (anti tumor necrosis factor) like Enbrel or Remicade, since both have better track records for Still's? You should ask him/her. Hope that helps. in Maine Adverse effects of indomethacin Since indomethacin inhibits both COX-1 and COX-2, it inhibits the production of prostaglandins in the stomach and intestines which maintain the mucous lining of the gastrointestinal tract. Indomethacin, therefore, like other nonselective COX inhibitors, can cause ulcers. The ulcers can result in serious bleeding and/or perforation requirering hospitilization of the patient. Some even die from these complications. To reduce the possibility of peptic ulcers, indomethacin should be prescribed at the lowest dosage needed to achieve a therapeutic effect, usually between 50–200 mg/day. It should always be taken after a meal. Nearly all patients benefit from an ulcer protective drug (e.g. highly dosed antacids, ranitidine 150mg at bedtime, or omeprazol 20mg at bedtime). Other common seen gastrointestinal complaints as dyspepsia, heartburn and mild diarrhea are harmless in nature and rarely require discontinuation of Indomethacin. Many NSAIDs, but particularly indomethacin, cause lithium retention by reducing its excretion by the kidneys. Thus indomethacin users have an elevated risk of lithium toxicity. For patients taking lithium supplements (e.g. for treatment of depression or bipolar disorder), less toxic NSAIDs such as sulindac or aspirin, are preferred. Indomethacin also reduces plasma renin activity and aldosterone levels, and increases sodium and potassium retention. It also enhances the effects of vasopressin. Together these may lead to: edema (swelling due to fluid retention) hyperkalemia (high potassium levels) hypernatremia (high sodium levels) hypertension (high blood pressure) The drug may also cause elevations of serum creatinine and more serious renal damage such as acute renal failure, chronic nephritis and nephrotic syndrome. These conditions also often begin with edema and hyperkalema. Additionally, Indomethacin quite often causes headache (10 to 20%), sometimes with vertigo and dizziness, hearing loss, tinnitus, blurred vision with or without retinal damage and worsens Parkinson's disease, epilepsy, and psychic disorders. Cases of life- threatening shock (including angioedema, sweating, severe hypotension and tachycardia as well as acute bronchospasm), severe or lethal hepatits and severe bone marrow damage have all been seen. Skin reactions and photosensitivity are also possible side effects. Due to its strong antipyretic activity Indomethacin may obscure the clinical course of serious infections. The frequency and severity of side effects and the availability of better tolerated alternatives make Indomethacin today a drug of second choice. Its use in acute gout attacks and in dysmennorhea is well established because in these indications the duration of treatment is limited to a few days only, therefore serious side effects are not likely to occur. > > Quick question – has anybody been on this before? > > > > If so can you give me personal experiences of it … did it work, how long > were/are you on it, side effects etc? What did you take it alongside? > > > > Cheers, Steve > > > > > > > -- > No virus found in this incoming message. > Checked by AVG Free Edition. > Version: 7.1.392 / Virus Database: 268.5.5/333 - Release Date: 05/05/2006 > > > > -- > No virus found in this outgoing message. > Checked by AVG Free Edition. > Version: 7.1.392 / Virus Database: 268.5.5/333 - Release Date: 05/05/2006 > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 6, 2006 Report Share Posted May 6, 2006 I've been on Indomethacin for about two years now. At first it worked AMAZINGLY. Took away soooo much of the fevers, rash, joint swelling, overall pain. I took it with plaquenil. After about 3-4 months it's grand effects lessened and indo alone was not cutting it. I still take it and know it works but in no way tames my dragon sufficiantly alone. Enbrel, MTX, indo, plaqu, and pain killers do the trick for me now. So I'm happy on it, oh and one side effect that I noticed was at first my face broke out like CRAZY with blemishes... I was horrified! Then about two or three weeks later it all cleared up and to this day I dont get blemishes. Its better than any achne cream out there!!! Hope that helps Lori in California --- wrote: > Quick question – has anybody been on this before? > > > > If so can you give me personal experiences of it … > did it work, how long > were/are you on it, side effects etc? What did you > take it alongside? > > > > Cheers, Steve > > > > > > > -- > No virus found in this incoming message. > Checked by AVG Free Edition. > Version: 7.1.392 / Virus Database: 268.5.5/333 - > Release Date: 05/05/2006 > > > > -- > No virus found in this outgoing message. > Checked by AVG Free Edition. > Version: 7.1.392 / Virus Database: 268.5.5/333 - > Release Date: 05/05/2006 > > > > [Non-text portions of this message have been > removed] > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 7, 2006 Report Share Posted May 7, 2006 , I’m also on Cyclophosphamide which is used for RA and is also a chemo drug. Rheumy said I wouldn’t qualify for the Infliximab (Remicade) so I have to make do with what I’m on – unless I paid for it myself. He said I would have to fail the Cyc before I went on Remicade. The question is: How could one fail it, if their blood results were normal but it didn’t work with the joint pain? Steve _____ From: Stillsdisease [mailto:Stillsdisease ] On Behalf Of Sent: 07 May 2006 01:13 To: Stillsdisease Subject: Re: Indomethacin , I've never taken it, but I've heard of it. It's an NSAID (non sterodial anti inflammatory drug) (like Celebrex) but usually used only for VERY short term because of potential side effects. I've cut and pasted below some info from Medline. I think you posted a question about Celebrex the other day too. I took it off and on for years for neck problems from a car accident, but stopped taking it when all the news broke about Celebrex and Vioxx causing heart and respiratory problems. I'm curious as to why your doc is trying so many different NSAIDs on you--wouldn't it make more sense to try a DMARD (disease modifying anti rheumatic drug) like methotrexate or an Anti-TNF (anti tumor necrosis factor) like Enbrel or Remicade, since both have better track records for Still's? You should ask him/her. Hope that helps. in Maine Adverse effects of indomethacin Since indomethacin inhibits both COX-1 and COX-2, it inhibits the production of prostaglandins in the stomach and intestines which maintain the mucous lining of the gastrointestinal tract. Indomethacin, therefore, like other nonselective COX inhibitors, can cause ulcers. The ulcers can result in serious bleeding and/or perforation requirering hospitilization of the patient. Some even die from these complications. To reduce the possibility of peptic ulcers, indomethacin should be prescribed at the lowest dosage needed to achieve a therapeutic effect, usually between 50–200 mg/day. It should always be taken after a meal. Nearly all patients benefit from an ulcer protective drug (e.g. highly dosed antacids, ranitidine 150mg at bedtime, or omeprazol 20mg at bedtime). Other common seen gastrointestinal complaints as dyspepsia, heartburn and mild diarrhea are harmless in nature and rarely require discontinuation of Indomethacin. Many NSAIDs, but particularly indomethacin, cause lithium retention by reducing its excretion by the kidneys. Thus indomethacin users have an elevated risk of lithium toxicity. For patients taking lithium supplements (e.g. for treatment of depression or bipolar disorder), less toxic NSAIDs such as sulindac or aspirin, are preferred. Indomethacin also reduces plasma renin activity and aldosterone levels, and increases sodium and potassium retention. It also enhances the effects of vasopressin. Together these may lead to: edema (swelling due to fluid retention) hyperkalemia (high potassium levels) hypernatremia (high sodium levels) hypertension (high blood pressure) The drug may also cause elevations of serum creatinine and more serious renal damage such as acute renal failure, chronic nephritis and nephrotic syndrome. These conditions also often begin with edema and hyperkalema. Additionally, Indomethacin quite often causes headache (10 to 20%), sometimes with vertigo and dizziness, hearing loss, tinnitus, blurred vision with or without retinal damage and worsens Parkinson's disease, epilepsy, and psychic disorders. Cases of life- threatening shock (including angioedema, sweating, severe hypotension and tachycardia as well as acute bronchospasm), severe or lethal hepatits and severe bone marrow damage have all been seen. Skin reactions and photosensitivity are also possible side effects. Due to its strong antipyretic activity Indomethacin may obscure the clinical course of serious infections. The frequency and severity of side effects and the availability of better tolerated alternatives make Indomethacin today a drug of second choice. Its use in acute gout attacks and in dysmennorhea is well established because in these indications the duration of treatment is limited to a few days only, therefore serious side effects are not likely to occur. > > Quick question – has anybody been on this before? > > > > If so can you give me personal experiences of it … did it work, how long > were/are you on it, side effects etc? What did you take it alongside? > > > > Cheers, Steve > > > > > > > -- > No virus found in this incoming message. > Checked by AVG Free Edition. > Version: 7.1.392 / Virus Database: 268.5.5/333 - Release Date: 05/05/2006 > > > > -- > No virus found in this outgoing message. > Checked by AVG Free Edition. > Version: 7.1.392 / Virus Database: 268.5.5/333 - Release Date: 05/05/2006 > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 7, 2006 Report Share Posted May 7, 2006 Hi Lori, When you say these do the trick for you do you mean you are pretty much pain free? At the moment I’m on 1250mg of Cyclophosamide every 4 weeks 10mg Pred 4grams of Sulphasalzine I then take the Indo and things like Paracetamol sometimes. Steve _____ From: Stillsdisease [mailto:Stillsdisease ] On Behalf Of Lori Brown Sent: 07 May 2006 01:54 To: Stillsdisease Subject: Re: Indomethacin I've been on Indomethacin for about two years now. At first it worked AMAZINGLY. Took away soooo much of the fevers, rash, joint swelling, overall pain. I took it with plaquenil. After about 3-4 months it's grand effects lessened and indo alone was not cutting it. I still take it and know it works but in no way tames my dragon sufficiantly alone. Enbrel, MTX, indo, plaqu, and pain killers do the trick for me now. So I'm happy on it, oh and one side effect that I noticed was at first my face broke out like CRAZY with blemishes... I was horrified! Then about two or three weeks later it all cleared up and to this day I dont get blemishes. Its better than any achne cream out there!!! Hope that helps Lori in California --- wrote: > Quick question – has anybody been on this before? > > > > If so can you give me personal experiences of it … > did it work, how long > were/are you on it, side effects etc? What did you > take it alongside? > > > > Cheers, Steve > > > > > > > -- > No virus found in this incoming message. > Checked by AVG Free Edition. > Version: 7.1.392 / Virus Database: 268.5.5/333 - > Release Date: 05/05/2006 > > > > -- > No virus found in this outgoing message. > Checked by AVG Free Edition. > Version: 7.1.392 / Virus Database: 268.5.5/333 - > Release Date: 05/05/2006 > > > > [Non-text portions of this message have been > removed] > > > > Quote Link to comment Share on other sites More sharing options...
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