Guest guest Posted September 3, 2006 Report Share Posted September 3, 2006 My rheumy just diagnosed me with RA. She prescribed folic acid & methotrexate. I took both on Thursday night. Friday morning, I awoke vomiting & with diarrhea. I couldn't have gotten out of bed on Friday if my house had been of fire. Same for Saturday. I have never felt so groggy and sleepy. I slept off & on for two days. (mostly sleeping) My question is this: Is this what I can expect every time i take methotrexate? I am also on meds for bi-polar, anxiety, & depression. All of these make me sleepy as well. How does anyone work this way? Thanks, Sadie Quote Link to comment Share on other sites More sharing options...
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