RESEARCH - Ear-nose-throat manifestations of autoimmune rheumatic diseases

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Clin Exp Rheumatol. 2004 Jul-Aug;22(4):485-94.

Ear-nose-throat manifestations of autoimmune rheumatic diseases.

Department of Rheumatology, Clinical Immunology and Allergy, University

Hospital, Medical School, University of Crete, Heraklion, Greece.

Ear-nose-throat (ENT) manifestations of connective tissue disorders

represent a diagnostic challenge for clinicians as they often constitute the

initial sign of an otherwise asymptomatic autoimmune disease. Moreover, in

patients with known autoimmune rheumatic diseases, ENT manifestations can be

overlooked. Hearing disturbances may be seen in patients with systemic lupus

erythematosus, Wegener's granulomatosis, relapsing polychondritis,

polyarteritis nodosa, Cogan's syndrome, Sjogren's syndrome, and less

frequently in Churg-Strauss syndrome and Adamantiades-Behcet's disease. Nose

and paranasal sinuses are variably affected during the course of Wegener's

granulomatosis, Churg-Strauss syndrome, relapsing polychondritis and

sarcoidosis. Recurrent mucosal ulcerations are common in systemic lupus

erythematosus and Adamantiades-Behcet's disease. Xerostomia is a common

feature of primary and secondary Sjogren's syndrome; salivary gland

enlargement may be also seen in these patients, as well as in patients with

sarcoidosis. The cricoarytenoid joint can be involved during the course of

rheumatoid arthritis, ankylosing spondylitis and gout; osteoarthritic

changes have also been described. Motility disorders of the upper and/or the

lower portions of the esophagus have been reported in patients with

dermatomyositis/polymyositis, systemic sclerosis and systemic lupus

erythematosus. Trigeminal nerve dysfunction may occur in patients with

Sjogren's syndrome, systemic sclerosis, systemic lupus erythematosus and

mixed connective tissue disease. Peripheral facial nerve palsy has been

described to complicate the course of Sjogren's syndrome and sarcoidosis.

PMID: 15301251

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrieve & dopt=Abstra\

ctPlus & list_uids=15301251

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