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eating non-edible items.rhondabalque wrote: Could some explain to me what PICA is my daughter will at time shed paper and eat it or chew on it and give it to me.

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PICA is the eating, chewing, or mouthing

of inedible objects. My son chews on paper and plastic. To our knowledge,

however, he does not swallow them. He spits them back out.

Pamela

" Courage is doing

what you're afraid to do. There can be no courage unless you're scared. "

Eddie Rickenbacker,

top US

fighter ace, WWI

From: mb12 valtrex [mailto:mb12 valtrex ] On Behalf Of rhondabalque

Sent: Friday, January 04, 2008

9:09 PM

To: mb12 valtrex

Subject: What is

PICA

Could some

explain to me what PICA is my

daughter will at time shed

paper and eat it or chew on it and give it to me.

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I think pica is usually linked to zinc deficiency. My daughter had pica and it went away when we started supplementing zinc.

From: mb12 valtrex [mailto:mb12 valtrex ] On Behalf Of Pamela LeighSent: Saturday, January 05, 2008 12:23 PMTo: mb12 valtrex Subject: RE: What is PICA

PICA is the eating, chewing, or mouthing of inedible objects. My son chews on paper and plastic. To our knowledge, however, he does not swallow them. He spits them back out.

Pamela

"Courage is doing what you're afraid to do. There can be no courage unless you're scared."

Eddie Rickenbacker, top US fighter ace, WWI

From: mb12 valtrex [mailto:mb12 valtrex ] On Behalf Of rhondabalqueSent: Friday, January 04, 2008 9:09 PMTo: mb12 valtrex Subject: What is PICA

Could some explain to me what PICA is my daughter will at time shed paper and eat it or chew on it and give it to me.

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My son has always had bad pica and we just got back

spectracell results that say he is zinc deficient. May

I ask which zinc you used? I was just researching and

founf their are different forms. Thank you,

--- Chuck & Chase wrote:

> I think pica is usually linked to zinc deficiency.

> My daughter had pica and

> it went away when we started supplementing zinc.

>

>

>

> _____

>

> From: mb12 valtrex

> [mailto:mb12 valtrex ] On

> Behalf Of Pamela Leigh

> Sent: Saturday, January 05, 2008 12:23 PM

> To: mb12 valtrex

> Subject: RE: What is PICA

>

>

>

>

> PICA is the eating, chewing, or mouthing of inedible

> objects. My son chews

> on paper and plastic. To our knowledge, however, he

> does not swallow them.

> He spits them back out.

>

> Pamela

>

> " Courage is doing what you're afraid to do. There

> can be no courage unless

> you're scared. "

>

> Eddie Rickenbacker, top US fighter ace, WWI

>

> _____

>

> From: mb12 valtrex

> [mailto:mb12 valtrex ] On

> Behalf Of rhondabalque

> Sent: Friday, January 04, 2008 9:09 PM

> To: mb12 valtrex

> Subject: What is PICA

>

> Could some explain to me what PICA is my daughter

> will at time shed

> paper and eat it or chew on it and give it to me.

>

>

>

________________________________________________________________________________\

____

Never miss a thing. Make Yahoo your home page.

http://www.yahoo.com/r/hs

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Did you find the Spectracell results helpful? I am waiting on our results. We did the FIA test.CarolynMy son has always had bad pica and we just got backspectracell results that say he is zinc deficient. MayI ask which zinc you used? I was just researching andfounf their are different forms. Thank you, --- Chuck & Chase <cachase> wrote:> I think pica is usually linked to zinc deficiency. > My daughter had pica and> it went away when we started supplementing zinc.> > > > _____ > > From: mb12 valtrex > [mailto:mb12 valtrex ] On> Behalf Of Pamela Leigh> Sent: Saturday, January 05, 2008 12:23 PM> To: mb12 valtrex > Subject: RE: What is PICA> > > > > PICA is the eating, chewing, or mouthing of inedible> objects. My son chews> on paper and plastic. To our knowledge, however, he> does not swallow them.> He spits them back out.> > Pamela > > "Courage is doing what you're afraid to do. There> can be no courage unless> you're scared."> > Eddie Rickenbacker, top US fighter ace, WWI> > _____ > > From: mb12 valtrex > [mailto:mb12 valtrex ] On> Behalf Of rhondabalque> Sent: Friday, January 04, 2008 9:09 PM> To: mb12 valtrex > Subject: What is PICA> > Could some explain to me what PICA is my daughter> will at time shed > paper and eat it or chew on it and give it to me.> > > __________________________________________________________Never miss a thing. Make Yahoo your home page. http://www.yahoo.com/r/hs

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kirkmans has a good liquid zinc (has a fruity flavor) It helped my daughter with the chewing/mouthing of things."L. T" wrote: My son has always had bad pica and we just got backspectracell results that say he is zinc deficient. MayI ask which zinc you used? I was just researching andfounf their are different forms. Thank you, --- Chuck & Chase <cachase> wrote:> I think pica is usually linked to zinc deficiency. > My daughter

had pica and> it went away when we started supplementing zinc.> > > > _____ > > From: mb12 valtrex > [mailto:mb12 valtrex ] On> Behalf Of Pamela Leigh> Sent: Saturday, January 05, 2008 12:23 PM> To: mb12 valtrex > Subject: RE: What is PICA> > > > > PICA is the eating, chewing, or mouthing of inedible> objects. My son chews> on paper and plastic. To our knowledge, however, he> does not swallow them.> He spits them back out.> > Pamela > > "Courage is doing what you're afraid to do. There> can be no courage unless> you're scared."> >

Eddie Rickenbacker, top US fighter ace, WWI> > _____ > > From: mb12 valtrex > [mailto:mb12 valtrex ] On> Behalf Of rhondabalque> Sent: Friday, January 04, 2008 9:09 PM> To: mb12 valtrex > Subject: What is PICA> > Could some explain to me what PICA is my daughter> will at time shed > paper and eat it or chew on it and give it to me.> > > __________________________________________________________Never miss a thing. Make Yahoo your home page. http://www.yahoo.com/r/hs

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I just got them yesterday and have not had a chance to

go over them with my son's doc They did coincide with

some other tests I had run. The only thing I need to

ask about is the fact that the test said the reference

ranges are for children " 12 yrs and up. My child is 4

yrs old. I am also doing the " Doctor's Data cell

elements test " as per my DAN!. I like to compare test

results (while it kills my pocket book) to be sure.

I'll keep you posted.

--- thatgirl wrote:

> Did you find the Spectracell results helpful? I am

> waiting on our

> results. We did the FIA test.

>

> Carolyn

>

>

>

> > My son has always had bad pica and we just got

> back

> > spectracell results that say he is zinc deficient.

> May

> > I ask which zinc you used? I was just researching

> and

> > founf their are different forms. Thank you,

> > --- Chuck & Chase wrote:

> >

> > > I think pica is usually linked to zinc

> deficiency.

> > > My daughter had pica and

> > > it went away when we started supplementing zinc.

> > >

> > >

> > >

> > > _____

> > >

> > > From: mb12 valtrex

> > > [mailto:mb12 valtrex ] On

> > > Behalf Of Pamela Leigh

> > > Sent: Saturday, January 05, 2008 12:23 PM

> > > To: mb12 valtrex

> > > Subject: RE: What is PICA

> > >

> > >

> > >

> > >

> > > PICA is the eating, chewing, or mouthing of

> inedible

> > > objects. My son chews

> > > on paper and plastic. To our knowledge, however,

> he

> > > does not swallow them.

> > > He spits them back out.

> > >

> > > Pamela

> > >

> > > " Courage is doing what you're afraid to do.

> There

> > > can be no courage unless

> > > you're scared. "

> > >

> > > Eddie Rickenbacker, top US fighter ace, WWI

> > >

> > > _____

> > >

> > > From: mb12 valtrex

> > > [mailto:mb12 valtrex ] On

> > > Behalf Of rhondabalque

> > > Sent: Friday, January 04, 2008 9:09 PM

> > > To: mb12 valtrex

> > > Subject: What is PICA

> > >

> > > Could some explain to me what PICA is my

> daughter

> > > will at time shed

> > > paper and eat it or chew on it and give it to

> me.

> > >

> > >

> > >

> >

> >

>

__________________________________________________________

> > Never miss a thing. Make Yahoo your home page.

> > http://www.yahoo.com/r/hs

> >

> >

>

>

________________________________________________________________________________\

____

Be a better friend, newshound, and

know-it-all with Yahoo! Mobile. Try it now.

http://mobile.yahoo.com/;_ylt=Ahu06i62sR8HDtDypao8Wcj9tAcJ

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We've used several different forms over the years. Kirkman's has a zinc sulfate cream that is used transdermally, which is nice if your child doesn't like pills.

From: mb12 valtrex [mailto:mb12 valtrex ] On Behalf Of L. TSent: Saturday, January 05, 2008 9:36 PMTo: mb12 valtrex Subject: RE: What is PICA

My son has always had bad pica and we just got backspectracell results that say he is zinc deficient. MayI ask which zinc you used? I was just researching andfounf their are different forms. Thank you, --- Chuck & Chase <cachase> wrote:> I think pica is usually linked to zinc deficiency. > My daughter had pica and> it went away when we started supplementing zinc.> > > > _____ > > From: mb12 valtrex > [mailto:mb12 valtrex ] On> Behalf Of Pamela Leigh> Sent: Saturday, January 05, 2008 12:23 PM> To: mb12 valtrex > Subject: RE: What is PICA> > > > > PICA is the eating, chewing, or mouthing of inedible> objects. My son chews> on paper and plastic. To our knowledge, however, he> does not swallow them.> He spits them back out.> > Pamela > > "Courage is doing what you're afraid to do. There> can be no courage unless> you're scared."> > Eddie Rickenbacker, top US fighter ace, WWI> > _____ > > From: mb12 valtrex > [mailto:mb12 valtrex ] On> Behalf Of rhondabalque> Sent: Friday, January 04, 2008 9:09 PM> To: mb12 valtrex > Subject: What is PICA> > Could some explain to me what PICA is my daughter> will at time shed > paper and eat it or chew on it and give it to me.> > > __________________________________________________________Never miss a thing. Make Yahoo your home page. http://www.yahoo.com/r/hs

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,

Pica can also be caused by iron deficiency.

I have an adult friend with polycystic kidney disease, and she (along with

many others with her condition) has pica. She has told me how she really

craves dirt, and how she has even sent off to her mother to get some dirt

from her hometown. PKD has issues with anemia and with the kidneys failing

to produce the chemical that encourages the body to make red blood

cells. It is also known that many of them have oxalate issues because

dialysis doesn't get rid of sufficient oxalate.

The molecule that delivers iron into our cells is called transferrin. This

molecule " holds " iron inside itself bound to a carbonate ion, and then it

releases the iron once inside the cell. Unfortunately, when oxalate is

high in the blood, it can muscle out the carbonate ion in transferrin and

sit in its place in the molecule. That works OK for binding iron, but

unfortunately, the oxalate works more like superglue, and it won't then

release the iron when it gets to the right place, so the iron is unuseable.

This probably explains why some kids that have been anemic despite taking

lots of supplemental iron may have their anemia correct without extra iron

when they finally get low in oxalate. This might help the pica, too, if it

was caused by iron deficiency that occurred in the context of high

oxalate. The tricky part in measuring the iron in this situation is that

it is still in the body, and maybe even inside the cells, but it is just

not getting to where it needs to go and doing what it needs to do. I don't

know this for certain, but it may be that the RBC mineral test would be

misleading if the oxalate had gotten into transferrin and was mucking up

the works!

Just some food for thought that may be particularly important for people

who may be thinking that the iron in spinach (which is extremely high

oxalate) would correct anemia.

Oxalate all by itself (without the enzyme) also binds iron, forming iron

oxalate. That would also take iron out of service.

If you still have anemia or develop pica while eating a high oxalate diet,

take note!

J Control Release. 2007 Feb 26;117(3):403-12. Epub 2006 Dec 8.[] Links

Inhibition of transferrin iron release increases in vitro drug carrier

efficacy.

Lao BJ, Tsai WL, Mashayekhi F, Pham EA, Mason AB, Kamei DT.

Department of Bioengineering, University of California, Los Angeles, CA

90095, USA.

Transferrin (Tf) conjugates of CRM107 are currently being tested in

clinical trials for treatment of malignant gliomas. However, the rapid

cellular recycling of Tf limits its efficiency as a drug carrier. We have

developed a mathematical model of the Tf/TfR trafficking cycle and have

identified the Tf iron release rate as a previously unreported factor

governing the degree of Tf cellular association. The release of iron from

Tf is inhibited by replacing the synergistic carbonate anion with oxalate.

Trafficking patterns for oxalate Tf and native Tf are compared by measuring

their cellular association with HeLa cells. The amount of Tf associated

with the cells is an average of 51% greater for oxalate Tf than for native

Tf over a two hour period at Tf concentrations of 0.1 nM and 1 nM.

Importantly, diphtheria toxin (DT) conjugates of oxalate Tf are more

cytotoxic against HeLa cells than conjugates of native Tf. Conjugate IC(50)

values were determined to be 0.06 nM for the oxalate Tf conjugate vs. 0.22

nM for the native Tf conjugate. Thus, we show that inhibition of Tf iron

release improves the efficacy of Tf as a drug carrier through increased

association with cells expressing TfR.

PMID: 17239470 [PubMed - indexed for MEDLINE]

At 05:57 PM 1/5/2008, you wrote:

>I think pica is usually linked to zinc deficiency. My daughter had pica

>and it went away when we started supplementing zinc.

>

>

>

>

>----------

>From: mb12 valtrex [mailto:mb12 valtrex ] On

>Behalf Of Pamela Leigh

>Sent: Saturday, January 05, 2008 12:23 PM

>To: mb12 valtrex

>Subject: RE: What is PICA

>

>PICA is the eating, chewing, or mouthing of inedible objects. My son

>chews on paper and plastic. To our knowledge, however, he does not

>swallow them. He spits them back out.

>

>Pamela

>

> " Courage is doing what you're afraid to do. There can be no courage

>unless you're scared. "

>

>Eddie Rickenbacker, top US fighter ace, WWI

>

>

>----------

>From: mb12 valtrex [mailto:mb12 valtrex ] On

>Behalf Of rhondabalque

>Sent: Friday, January 04, 2008 9:09 PM

>To: mb12 valtrex

>Subject: What is PICA

>

>Could some explain to me what PICA is my daughter will at time shed

>paper and eat it or chew on it and give it to me.

>

>

--

Internal Virus Database is out-of-date.

Checked by AVG Free Edition.

Version: 7.5.503 / Virus Database: 269.17.8/1196 - Release Date: 12/25/2007

12:18 PM

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