Re: Bacteria causing depression

[Guest guest]

I think it is for this reason that Yasko recommends a little

tryptophan.

Gayatri

>

> Mol Psychiatry. 2008 Jan 15 [Epub ahead of print]

> Lipopolysaccharide-induced depressive-like behavior is mediated by

> indoleamine 2,3-dioxygenase activation in mice.O'Connor JC

> <http://www.ncbi.nlm.nih.gov/sites/entrez?

Db=pubmed & Cmd=Search & Term=%22O\

> %27Connor%20JC%22%5BAuthor%

5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_\

> ResultsPanel.Pubmed_RVAbstractPlus> ...Integrative Immunology and

> Behavior, Department of Animal Sciences, College of Agricultural,

> Consumer and Environmental Sciences, University of Illinois at

> Urbana-Champaign, Urbana, IL, USA.

> Although elevated activity of the tryptophan-degrading enzyme

> indoleamine 2,3-dioxygenase (IDO) has been proposed to mediate

comorbid

> depression in inflammatory disorders, its causative role has never

been

> tested. We report that peripheral administration of

lipopolysaccharide

> (LPS) activates IDO and culminates in a distinct depressive-like

> behavioral syndrome, measured by increased duration of immobility in

> both the forced-swim and tail suspension tests. Blockade of IDO

> activation either indirectly with the anti-inflammatory tetracycline

> derivative minocycline, that attenuates LPS-induced expression of

> proinflammatory cytokines, or directly with the IDO antagonist

> 1-methyltryptophan (1-MT), prevents development of depressive-like

> behavior. Both minocycline and 1-MT normalize the

kynurenine/tryptophan

> ratio in the plasma and brain of LPS-treated mice without changing

the

> LPS-induced increase in turnover of brain serotonin. Administration

of

> L-kynurenine, a metabolite of tryptophan that is generated by IDO,

to

> naive mice dose dependently induces depressive-like behavior. These

> results implicate IDO as a critical molecular mediator of

> inflammation-induced depressive-like behavior, probably through the

> catabolism of tryptophan along the kynurenine pathway.Molecular

> Psychiatry advance online publication, 15 January 2008;

> doi:10.1038/sj.mp.4002148.

>

> PMID: 18195714 [PubMed - as supplied by publisher]

>

[Guest guest]

Is the article saying that tryptophan is helpful or partly the cause?

Karmen

Re: Bacteria causing depression

I think it is for this reason that Yasko recommends a little tryptophan.Gayatri>> Mol Psychiatry. 2008 Jan 15 [Epub ahead of print]> Lipopolysaccharide-induced depressive-like behavior is mediated by> indoleamine 2,3-dioxygenase activation in mice.O'Connor JC> <http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & Cmd=Search & Term=%22O\> %27Connor%20JC%22%5BAuthor%5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_\> ResultsPanel.Pubmed_RVAbstractPlus> ...Integrative Immunology and> Behavior, Department of Animal Sciences, College of Agricultural,> Consumer and Environmental Sciences, University of Illinois at> Urbana-Champaign, Urbana, IL, USA.> Although elevated activity of the tryptophan-degrading enzyme> indoleamine 2,3-dioxygenase (IDO) has been proposed to mediate comorbid> depression in inflammatory disorders, its causative role has never been> tested. We report that peripheral administration of lipopolysaccharide> (LPS) activates IDO and culminates in a distinct depressive-like> behavioral syndrome, measured by increased duration of immobility in> both the forced-swim and tail suspension tests. Blockade of IDO> activation either indirectly with the anti-inflammatory tetracycline> derivative minocycline, that attenuates LPS-induced expression of> proinflammatory cytokines, or directly with the IDO antagonist> 1-methyltryptophan (1-MT), prevents development of depressive-like> behavior. Both minocycline and 1-MT normalize the kynurenine/tryptophan> ratio in the plasma and brain of LPS-treated mice without changing the> LPS-induced increase in turnover of brain serotonin. Administration of> L-kynurenine, a metabolite of tryptophan that is generated by IDO, to> naive mice dose dependently induces depressive-like behavior. These> results implicate IDO as a critical molecular mediator of> inflammation-induced depressive-like behavior, probably through the> catabolism of tryptophan along the kynurenine pathway.Molecular> Psychiatry advance online publication, 15 January 2008;> doi:10.1038/sj.mp.4002148.> > PMID: 18195714 [PubMed - as supplied by publisher]>

[Guest guest]

I think the Yasko logic was that since tryptophan was broken down and

used up it would be wise to replenish it for the body to use.

Gayatri

> >

> > Mol Psychiatry. 2008 Jan 15 [Epub ahead of print]

> > Lipopolysaccharide-induced depressive-like behavior is mediated

by

> > indoleamine 2,3-dioxygenase activation in mice.O'Connor JC

> > <http://www.ncbi.nlm.nih.gov/sites/entrez?

> Db=pubmed & Cmd=Search & Term=%22O\

> > %27Connor%20JC%22%5BAuthor%

> 5D & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_\

> > ResultsPanel.Pubmed_RVAbstractPlus> ...Integrative Immunology

and

> > Behavior, Department of Animal Sciences, College of

Agricultural,

> > Consumer and Environmental Sciences, University of Illinois at

> > Urbana-Champaign, Urbana, IL, USA.

> > Although elevated activity of the tryptophan-degrading enzyme

> > indoleamine 2,3-dioxygenase (IDO) has been proposed to mediate

> comorbid

> > depression in inflammatory disorders, its causative role has

never

> been

> > tested. We report that peripheral administration of

> lipopolysaccharide

> > (LPS) activates IDO and culminates in a distinct depressive-like

> > behavioral syndrome, measured by increased duration of

immobility in

> > both the forced-swim and tail suspension tests. Blockade of IDO

> > activation either indirectly with the anti-inflammatory

tetracycline

> > derivative minocycline, that attenuates LPS-induced expression

of

> > proinflammatory cytokines, or directly with the IDO antagonist

> > 1-methyltryptophan (1-MT), prevents development of depressive-

like

> > behavior. Both minocycline and 1-MT normalize the

> kynurenine/tryptophan

> > ratio in the plasma and brain of LPS-treated mice without

changing

> the

> > LPS-induced increase in turnover of brain serotonin.

Administration

> of

> > L-kynurenine, a metabolite of tryptophan that is generated by

IDO,

> to

> > naive mice dose dependently induces depressive-like behavior.

These

> > results implicate IDO as a critical molecular mediator of

> > inflammation-induced depressive-like behavior, probably through

the

> > catabolism of tryptophan along the kynurenine pathway.Molecular

> > Psychiatry advance online publication, 15 January 2008;

> > doi:10.1038/sj.mp.4002148.

> >

> > PMID: 18195714 [PubMed - as supplied by publisher]

> >

>