Guest guest Posted January 3, 2008 Report Share Posted January 3, 2008 Hi EVERYONE We got the urine amino acid test result from Great plain I am concer about 3 thins has anyone had similar issues and what can be done for them any suggestion much appreciated Beta Alanine is ver high 86 ref range <20 Carnosine is high 770 ref range<500 1-Metlyhistidine is 540 ref range 115-430 Thanks Yahya Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 3, 2008 Report Share Posted January 3, 2008 > > > Hi EVERYONE > > We got the urine amino acid test result from Great plain > > I am concer about 3 thins has anyone had similar issues and what can > be done for them > any suggestion much appreciated > > Beta Alanine is ver high 86 ref range <20 > Carnosine is high 770 ref range<500 > 1-Metlyhistidine is 540 ref range 115-430 > > > Thanks > Yahya >Beta Alanine might be high due to bacteria and fungus overgrowth or high asparatic acid, and beta-alanine will inhibit carnosne and Arserine, so the arserine should be high? try less meat diet, and Yasko beleves if all those 3 come to normal range it is time to add DMG. i hope it helps. happy new year. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 4, 2008 Report Share Posted January 4, 2008 Yahya, Was taurine elevated too? Most of the time beta alanine levels go up because the transporter that reabsorbs beta alanine also reabsorbs taurine, and when taurine levels in the blood are high, there is just too much of both of these compounds to reabsorb it all. If taurine is not high, this could be an issue with a different transporter. Methylhistidine and histidine and beta alanine share transport via NBAT, a neutral and basic amino acid transporter. If this is the issue, you might see an elevation in cystine in the urine when plasma cystine is not elevated. You didn't mention taurine or cystine being out of range. The NBAT transporter (and many other transporters that help us reabsorb amino acids) change in their ability to transport amino acids based on pH. You may find that changes in his pH are hurting reabsorption. You could certainly monitor urinary pH, and do what you can to balance his pH. You can buy testing strips for pH at the pharmacy that you can use at home. How much protein does your child eat? Is it normal for his age? The body goes after the body's muscle trying to compensate when dietary protein gets too low. 3- methylhistidine is the more frequent marker of muscle catabolism, but it and 1-Methylhistidine being high can be a sign of muscle breakdown which might occur if you are restricting protein too much or under other stresses like what happens when carbohydrate gets too low,. When the body isn't getting enough carbohydrate, muscle breakdown might occur for a process called gluconeogenesis. In that case, you might see elevated plasma alanine. But, 1-methylhistidine can also be formed from eating too much muscle meat, so it is really important to evaluate where the methylhistidine is coming from, for what you do about it is completely opposite based on which source it represents. How old is your child? How much protein does he get per day from meat? From other sources? Maybe this will help: From: http://www.bcm.edu/cnrc/consumer/archives/proteinchildren.htm The Recommended Dietary Allowances (RDA) for protein are based on body weight and include age-related adjustments for the extra protein needed for growth, said nutritionists at the USDA/ARS Children's Nutrition Research Center at Baylor College of Medicine in Houston. Healthy 1-to-3-year-old children need 0.55 grams of protein per pound of body weight per day, which means the average 29-pound toddler needs 16 grams of protein each day. The RDAs for older children are 0.5 grams of protein per pound of body weight for 4-to-6-year-olds; 0.45 grams for 7-to-14-year olds; and 0.4 grams for 15-to-18-year-old boys. The RDA for girls over 15 and boys over 18 is 0.36 grams of protein per pound of body weight, the same as for adults. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jul 5;821(1):53-9. Related Articles, Links Click here to read Determination of 3-methylhistidine and 1-methylhistidine in untreated urine samples by capillary electrophoresis. Tuma P, Samcova E, Balinova P. University, 3rd Faculty of Medicine, Centre of Biomedical Sciences, Ruska 87, 100 00 Prague 10, Czech Republic. Capillary electrophoretic (CE) method was developed for the determination of urinary 3-methylhistidine (3MH) and 1-methylhistidine (1MH) indicating the extent of degradation of skeletal muscle proteins and thereby the state of human health. .... PMID: 15899597 [PubMed - indexed for MEDLINE] Metabolism. 1987 Dec;36(12):1175-84.Links Urinary excretion of 1-methylhistidine: a qualitative indicator of exogenous 3-methylhistidine and intake of meats from various sources. Sjölin J, Hjort G, Friman G, Hambraeus L. Department of Infectious Diseases, University Hospital, Uppsala, Sweden. In order to investigate whether the urinary excretion of 1-methylhistidine (1MH) might serve as an objective indicator of meat ingestion and exogenous 3-methylhistidine (3MH) intake, healthy subjects were fed an ovolactovegetarian diet. At five-day intervals they were given meat of different origin and 24-hour urinary excretions of 1MH and 3MH were determined. After beef intake there was a marked increase of 3MH and 1MH excretion. The elimination curves were found to follow first-order kinetics and to indicate similar elimination rates. 1MH was present in ten different types of meat analyzed. A strong linear relationship was found between increase in 3MH and 1MH excretion and the amount of chicken, pork, or plaice ingested. IMH may serve as an objective indicator of meat and exogenous 3MH intake, since it is present in meat, and, regardless of source, shows similar dose-independent kinetics, and has similar half-life to 3MH. PMID: 3683186 [PubMed - indexed for MEDLINE] Ann Surg. 1985 Jul;202(1):21-7.[] Links Whole-body protein breakdown and 3-methylhistidine excretion during brief fasting, starvation, and intravenous repletion in man. Lowry SF, Horowitz GD, Jeevanandam M, Legaspi A, Brennan MF. Simultaneous whole-body protein breakdown (using 15N-glycine) and urinary 3-methylhistidine (3MH) excretion rates were determined in six hospitalized normal volunteers after 10 days of starvation and a subsequent 10-day period of total parental nutrition (TPN). These data were contrasted to whole-body protein breakdown and urinary 3MH excretion in ten depleted (14.8% body weight loss) patients with benign intraabdominal disease studied in the basal (48 hours without nutrient intake) and intravenously refed states. The rates of whole-body protein breakdown were significantly reduced from basal (brief fasting or starvation) conditions in both normal volunteers (p less than 0.01) and depleted patients (p less than 0.01) during TPN. The rate of protein catabolism normalized for creatinine excretion in patients was higher than that observed in normal subjects during both basal (p less than 0.05) and intravenous feeding conditions. Daily urinary 3MH excretion was reduced during intravenous feeding in both starved normal volunteer (235 +/- 13 mumol/d to 197 +/- 9 mumol/d p less than 0.05) and in depleted patients (209 +/- 31 mumol/d to 140 +/- 35 mumol/d), and an apparent linear relationship between protein breakdown and urinary 3MH, normalized for creatinine excretion, was obtained in both volunteer and patient (r = 0.85) populations during fasting-refeeding. However, separate regression analysis of the protein breakdown and 3MH responses of both volunteer and patient groups under conditions of fasting, starvation, and refeeding revealed significant differences between volunteer and patient populations during intravenous refeeding (p less than 0.01). Further analysis of 3MH excretion in relationship to nitrogen balance during refeeding suggests a complex relationship between urinary 3MH excretion and whole-body protein metabolism that may be partly related to the degree of antecedent malnutrition. PMID: 3925903 [PubMed - indexed for MEDLINE] Biochem J. 1999 Oct 1;343 Pt 1:169-76.[] [] Links Interactions between the thiol-group reagent N-ethylmaleimide and neutral and basic amino acid transporter-related amino acid transport. GJ, Davies A, Watt PW, Birrell J, PM. Department of Anatomy and Physiology, University of Dundee, Dundee DD1 4HN, Scotland, U.K. The neutral and basic amino acid transport protein (NBAT) expressed in renal and jejunal brush-border membranes is involved in amino acid and cystine absorption. NBAT mutations result in Type 1 cystinuria....... The synthetic amino acid 2-trifluoromethylhistidine (TFMH) stimulated alanine efflux at pH 7.5 and arginine at pH 5.5, but not vice versa, establishing the existence of distinct pathways for cationic and neutral amino acid homoexchange (TFMH is zwitterionic at pH 7.5 and cationic at pH 5.5). We suggest that NBAT expresses a combination of system b(0,+) and y(+)L-like activities, possibly by interacting with different light-chain subunits endogenous to oocytes (as does the homologous 4F2hc protein). The C-terminus of NBAT may also have an additional, direct role in the mechanism of System b(0,+) transport (the major transport activity that is defective in Type 1 cystinuria). PMID: 10493926 [PubMed - indexed for MEDLINE] At 12:27 AM 1/4/2008, you wrote: > > > > > > > Hi EVERYONE > > > > We got the urine amino acid test result from Great plain > > > > I am concer about 3 thins has anyone had similar issues and what >can > > be done for them > > any suggestion much appreciated > > > > Beta Alanine is ver high 86 ref range <20 > > Carnosine is high 770 ref range<500 > > 1-Metlyhistidine is 540 ref range 115-430 > > > > > > Thanks > > Yahya > >Beta Alanine might be high due to bacteria and fungus overgrowth or >high asparatic acid, and beta-alanine will inhibit carnosne and >Arserine, so the arserine should be high? try less meat diet, and >Yasko beleves if all those 3 come to normal range it is time to add >DMG. i hope it helps. >happy new year. > > -- Internal Virus Database is out-of-date. Checked by AVG Free Edition. Version: 7.5.503 / Virus Database: 269.17.8/1196 - Release Date: 12/25/2007 12:18 PM Quote Link to comment Share on other sites More sharing options...
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