Carnitine and Q10: synergism and complementary action

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6: Int J Tissue React. 1990;12(3):183-6.

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Carnitine and coenzyme Q10: biochemical properties and functions,

synergism and complementary action.

Bertelli A, Ronca G.

Department of Pharmacology, University of Milan, Italy.

The mechanisms by which carnitine and coenzyme Q10 intervene in the

energetic metabolism are described. In particular, the metabolic stages

in which the action of carnitine is complementary to the action of

coenzyme Q10 are illustrated. The synergism of the pharmacological and

therapeutic actions that is found when these compounds are administered

together is explained on the basis of their biochemical and metabolic

complementarity.

Publication Types: * Review

PMID: 2276898 [PubMed - indexed for MEDLINE]

Arch Anim Nutr. 2007 Feb;61(1):50-60.

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Effects of dietary L-carnitine and coenzyme Q10 at different

supplemental ages on growth performance and some immune response in

ascites-susceptible broilers.

Geng A, Li B, Guo Y.

College of Animal Science and Technology, The State Key Lab of

Animal Nutrition, China Agricultural University, Beijing, PR China.

Effects of dietary L-carnitine and coenzyme Q10 (CoQ10) at different

supplemental ages on performance and some immune response were

investigated in ascites-susceptible broilers. A 3 x 2 x 2 factorial

design was used consisting of L-carnitine supplementation (0, 75, and

100 mg/kg), CoQ10 supplementation (0 and 40 mg/kg) and different

supplemental ages (from day 1 on and from day 10 on). A total of 480

one-day-old Arbor Acre male broiler chicks were randomly allocated to 12

groups, every group had five replicates, each with eight birds. The

birds were fed a corn-soybean based diet for six weeks. From day 10-21,

all the birds were exposed to a low ambient temperature (12-15 degrees

C) to increase the susceptibility to ascites. No significant effects

were observed on growth performance by L-carnitine, CoQ10

supplementation, and different supplemental ages. Packed cell volume was

significantly decreased by L-carnitine supplementation alone, and

ascites heart index and ascites mortality were decreased by L-carnitine,

CoQ10 supplementation alone, and L-carnitine + CoQ10 supplementation

together (p < 0.05). Heart index of broilers was significantly improved

by L-carnitine, CoQ10 supplementation alone during 0-3 week. Serum IgG

content was improved by L-carnitine supplementation alone (p < 0.05),

but lysozyme activity was increased by L-carnitine + CoQ10

supplementation together (p < 0.05). A significant L-carnitine by

supplemental age interaction was observed in lysozyme activity.

L-carnitine supplementation alone had no effects on the peripheral blood

lymphocyte (PBL) proliferation in response to concanavalin A (ConA) and

lipopolysaccharide, but supplemental CoQ10 alone and L-carnitine+ CoQ10

together decreased the PBL proliferation in response to ConA (p < 0.05).

The present study suggested that L-carnitine + CoQ10 supplementation

together had positive effects on some immune response of

ascites-susceptible broilers, which might benefit for the reduction of

broilers' susceptibility to ascites.

Publication Types: * Research Support, Non-U.S. Gov't

PMID: 17361948 [PubMed - indexed for MEDLINE]

2: Arch Anim Nutr. 2004 Dec;58(6):473-82.

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Effects of dietary L-carnitine and coenzyme Q10 supplementation on

performance and ascites mortality of broilers.

Geng A, Guo Y, Yuan J.

Department of Animal Nutrition and Feed Science, College of Animal

Science and Technology, China Agricultural University, Beijing, P R

China. ailiangengcau@...

The study was conducted to determine the effects of dietary

L-carnitine and coenzyme Q10 (CoQ10) supplementation on growth

performance and ascites mortality of broilers. A 3 x 3 factorial

arrangement was employed with three levels (0, 75 and 150 mg/kg) of

L-carnitine and three levels of CoQ10 (0, 20 and 40 mg/kg)

supplementation during the experiment. Five hundred and forty

one-day-old Arbor Acre male broiler chicks were randomly allocated into

nine groups with six replicates each. All birds were fed with the basal

diets from day 1 to 7 and changed to the experimental diets from day 8.

During day 15 to 21 all the birds were exposed to low ambient

temperature (15-18 degrees C) to induce ascites. The results showed that

under this condition, growth performance of broilers were not

significantly affected by CoQ10 or L-carnitine + CoQ10 supplementation

during week 0-3 and 0-6, but body weight gain (BWG) of broilers was

significantly reduced by 150 mg/ kg L-carnitine during week 0-6. Packed

cell volume (PCV) of broilers was significantly decreased by L-carnitine

and L-carnitine + CoQ10 supplementation (P < 0.05). Erythrocyte osmotic

fragility (EOF), ascites heart index (AHI) and ascites mortality of

broilers were significantly decreased by L-carnitine, CoQ10 and

L-carnitine + CoQ10 supplementation. Though no significant changes were

observed in total antioxidative capability (T-AOC), total superoxide

dismutase (T-SOD) was increased by L-carnitine, CoQ10 and L-carnitine +

CoQ10 supplementation (P < 0.05). Malonaldehyde (MDA) content was

significantly decreased by CoQ10 and L-carnitine + CoQ10

supplementation. The results indicate that dietary L-carnitine and CoQ10

supplementation reduce ascites mortality of broilers; the reason may be

partially associated with their antioxidative effects.

Publication Types:

* Research Support, Non-U.S. Gov't