tianeptine suppresses asthmatic symptoms in children

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Studies have shown that levels of free serotonin in plasma are

increased in symptomatic patients with asthma.

In addition, the concentration of free serotonin in symptomatic

patients with asthma correlates positively with clinical status and

negatively with pulmonary function.

Thus, reducing the concentration of free serotonin in plasma might be

useful in treating patients with asthma. We studied the effectiveness

of tianeptine in treating patients with asthma.

Tianeptine is the only drug known to be able to reduce levels of free

serotonin in plasma and to enhance uptake by platelets.

In this study, 69 children with asthma were assigned in randomized

fashion to receive tianeptine and/or placebo in a double-blind

crossover trial that lasted 52 weeks.

Tianeptine provoked a dramatic and sudden decrease in both clinical

rating and free serotonin plasma levels and an increase in pulmonary

function.

http://jcp.sagepub.com/cgi/content/abstract/38/10/918

Alana