Re: Testosterone & autoimmune enceph.

[Guest guest]

Interesting since the drug Lupron is being used off-label for/and reportedly

helps some boys with autism.

-

Doris and Steve <sjsmith@...> wrote:

ssages in this topic (3)

5.

testosterone in rats and the development of autoimmune

encephalomyel

<http://us.lrd./_ylc=X3oDMTJycGxqZ3V2BF9TAzk3MzU5NzE1BGdycElkAzE5NTc3Mj\

QEZ3Jwc3BJZAMxNjAwMDYxNjE2BG1zZ0lkAzY2NTkyBHNlYwNkbXNnBHNsawN2bXNnBHN0aW1lAzExND\

k4MDQwOTk-;_ylg=1/SIG=11lmvfgn3/**http%3a///group/abmd/message/6\

6592>

Posted by: " natasa778 " neno@...

<mailto:neno@...?Subject=Re:%20testosterone%20in%20rats%20and%20\

the%20development%20of%20autoimmune%20encephalomyel>

natasa778 <natasa778>

Thu Jun 8, 2006 3:35 am (PST)

Neuroimmunomodulation. 2005;12(4):246-54.

Oral testosterone in male rats and the development of experimental

autoimmune encephalomyelitis.

Maccio DR, Calfa G, Roth GA. Departamento de Quimica Biologica y

Centro de Investigaciones en Quimica Biologica de Cordoba, Facultad de

Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina.

OBJECTIVES: Considering that sex steroids can influence the immune

system, we studied the development of experimental autoimmune

encephalomyelitis (EAE), a T-cell-mediated autoimmune disease of the

central nervous system, and the concomitant cell-mediated immunity in

gonadally intact and gonadectomized male Wistar rats given testosterone

supplementation. METHODS/RESULTS: Sham-operated rats and surgically

castrated animals were orally self-administered with vehicle or

testosterone added in the water bottle for 20 days before EAE induction.

The androgenic effect of oral testosterone self-administration was

evidenced by changes in body weight, and in the weights of

androgen-dependent testes and seminal vesicles. Testosterone

administration reduced the incidence of clinical signs of EAE in

sham-operated animals and reversed the clinical symptoms of the disease

associated with castrated EAE animals. The clinical signs observed in

the different groups correlated with changes in delayed-type

hypersensitivity and mononuclear cell-proliferative responses to the

encephalitogenic myelin basic protein. Moreover, testosterone but not

cholesterol supplementation in vitro suppressed the proliferative

response of mononuclear cells to myelin basic protein suggesting that

testosterone may affect specific immune functions through direct actions

on immune cells. Finally, self-administration of testosterone induced

also elevated corticosterone levels that in sham-operated rats

correlated with the low incidence of the disease and in gonadectomized

animals could be involved in the remission of clinical symptoms of EAE.

CONCLUSIONS: These results suggest that orally self-administered

testosterone can modulate specific cellular immune responses and serum

corticosterone levels leading to changes in the development of EAE.

Copyright 2005 S. Karger AG, Basel.

PMID: 15990455 [PubMed - indexed for MEDLINE

[Guest guest]

What is the drug Lupron?? Also, I haven't seen the earlier thread on

this conversation, but I'm sure you are referring to the effect on

anti-myelin basic protein and relation to previous studies on autism.

Beverly

On Jun 10, 2006, at 1:39 AM, Rob or Sunseri wrote:

> Interesting since the drug Lupron is being used off-label for/and

> reportedly helps some boys with autism.

>

> -

>

>

> Doris and Steve <sjsmith@...> wrote:

> ssages in this topic (3)

>

> 5.

>

> testosterone in rats and the development of autoimmune

> encephalomyel

> <http://us.lrd./

> _ylc=X3oDMTJycGxqZ3V2BF9TAzk3MzU5NzE1BGdycElkAzE5NTc3MjQEZ3Jwc3BJZAMxN

> jAwMDYxNjE2BG1zZ0lkAzY2NTkyBHNlYwNkbXNnBHNsawN2bXNnBHN0aW1lAzExNDk4MDQ

> wOTk-;_ylg=1/SIG=11lmvfgn3/**http%3a///group/abmd/

> message/66592>

>

> Posted by: " natasa778 " neno@...

> <mailto:neno@...?Subject=Re:%20testosterone%20in%

> 20rats%20and%20the%20development%20of%20autoimmune%20encephalomyel>

> natasa778 <natasa778>

>

> Thu Jun 8, 2006 3:35 am (PST)

>

> Neuroimmunomodulation. 2005;12(4):246-54.

>

> Oral testosterone in male rats and the development of experimental

> autoimmune encephalomyelitis.

>

> Maccio DR, Calfa G, Roth GA. Departamento de Quimica Biologica y

> Centro de Investigaciones en Quimica Biologica de Cordoba, Facultad de

> Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba,

> Argentina.

>

> OBJECTIVES: Considering that sex steroids can influence the immune

> system, we studied the development of experimental autoimmune

> encephalomyelitis (EAE), a T-cell-mediated autoimmune disease of the

> central nervous system, and the concomitant cell-mediated immunity in

> gonadally intact and gonadectomized male Wistar rats given

> testosterone

> supplementation. METHODS/RESULTS: Sham-operated rats and surgically

> castrated animals were orally self-administered with vehicle or

> testosterone added in the water bottle for 20 days before EAE

> induction.

> The androgenic effect of oral testosterone self-administration was

> evidenced by changes in body weight, and in the weights of

> androgen-dependent testes and seminal vesicles. Testosterone

> administration reduced the incidence of clinical signs of EAE in

> sham-operated animals and reversed the clinical symptoms of the

> disease

> associated with castrated EAE animals. The clinical signs observed in

> the different groups correlated with changes in delayed-type

> hypersensitivity and mononuclear cell-proliferative responses to the

> encephalitogenic myelin basic protein. Moreover, testosterone but not

> cholesterol supplementation in vitro suppressed the proliferative

> response of mononuclear cells to myelin basic protein suggesting that

> testosterone may affect specific immune functions through direct

> actions

> on immune cells. Finally, self-administration of testosterone induced

> also elevated corticosterone levels that in sham-operated rats

> correlated with the low incidence of the disease and in gonadectomized

> animals could be involved in the remission of clinical symptoms of

> EAE.

> CONCLUSIONS: These results suggest that orally self-administered

> testosterone can modulate specific cellular immune responses and serum

> corticosterone levels leading to changes in the development of EAE.

> Copyright 2005 S. Karger AG, Basel.

>

> PMID: 15990455 [PubMed - indexed for MEDLINE

>

>

[Guest guest]

Beverly <bevanderson@...> wrote: What is the drug Lupron??

When ASD kids become teens, boys generally become worse, girls often improve

-- testosterone is cited by some as the culprit. Some docs are using Lupron on

preschool age ASD children and seeing improvements.

What is Lupron? • Lupron is related to a naturally

occurring hormone called gonadotropin-releasing hormone (GnRH). GnRH influences

the release of the hormones testosterone and estrogen in the body. •

Lupron is used to reduce the amount of testosterone or estrogen in the body. It

is used for conditions such as cancer of the prostate, endometriosis (growth of

uterine lining outside of the womb), uterine fibroids, and early puberty (before

8 years of age in females and 9 years of age in males). • Lupron may

also be used for purposes other than those listed in this medication guide.

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