Testosterone & autoimmune enceph.

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5.

testosterone in rats and the development of autoimmune

encephalomyel

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Posted by: " natasa778 " neno@...

<mailto:neno@...?Subject=Re:%20testosterone%20in%20rats%20and%20\

the%20development%20of%20autoimmune%20encephalomyel>

natasa778 <natasa778>

Thu Jun 8, 2006 3:35 am (PST)

Neuroimmunomodulation. 2005;12(4):246-54.

Oral testosterone in male rats and the development of experimental

autoimmune encephalomyelitis.

Maccio DR, Calfa G, Roth GA. Departamento de Quimica Biologica y

Centro de Investigaciones en Quimica Biologica de Cordoba, Facultad de

Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina.

OBJECTIVES: Considering that sex steroids can influence the immune

system, we studied the development of experimental autoimmune

encephalomyelitis (EAE), a T-cell-mediated autoimmune disease of the

central nervous system, and the concomitant cell-mediated immunity in

gonadally intact and gonadectomized male Wistar rats given testosterone

supplementation. METHODS/RESULTS: Sham-operated rats and surgically

castrated animals were orally self-administered with vehicle or

testosterone added in the water bottle for 20 days before EAE induction.

The androgenic effect of oral testosterone self-administration was

evidenced by changes in body weight, and in the weights of

androgen-dependent testes and seminal vesicles. Testosterone

administration reduced the incidence of clinical signs of EAE in

sham-operated animals and reversed the clinical symptoms of the disease

associated with castrated EAE animals. The clinical signs observed in

the different groups correlated with changes in delayed-type

hypersensitivity and mononuclear cell-proliferative responses to the

encephalitogenic myelin basic protein. Moreover, testosterone but not

cholesterol supplementation in vitro suppressed the proliferative

response of mononuclear cells to myelin basic protein suggesting that

testosterone may affect specific immune functions through direct actions

on immune cells. Finally, self-administration of testosterone induced

also elevated corticosterone levels that in sham-operated rats

correlated with the low incidence of the disease and in gonadectomized

animals could be involved in the remission of clinical symptoms of EAE.

CONCLUSIONS: These results suggest that orally self-administered

testosterone can modulate specific cellular immune responses and serum

corticosterone levels leading to changes in the development of EAE.

Copyright 2005 S. Karger AG, Basel.

PMID: 15990455 [PubMed - indexed for MEDLINE