Guest guest Posted September 16, 2006 Report Share Posted September 16, 2006 Hi, Do know of anyone who has used either one of these meds. and if so have they seen any results good or bad yet? TIA, >From: Aut2BMiracles@... >Reply- > >Subject: Re: Imunovir >Date: Fri, 15 Sep 2006 07:48:14 EDT > >Gaylen, > >I don't know much about Immunovir, but I have continued to look into >Nexavir. > >I did a google search and came across this link. It tells how to connect >with the FDA's site and shows the status of Nexavir's FDA approval. It is >currently on the FDA's site and shown as an approved medication. My >understanding >is that it's approval was grandfathered in the same way as Kutapressin. >Good >news! > > >http://www.nexcopharma.com/fda-info.htm > > >Sharon :-) > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 16, 2006 Report Share Posted September 16, 2006 Immunovir known as Isoprinosine or inosine pranobex is manufactured by Clonmel Healthcare Ltd, Waterford Rd, Co Tipperary, Ireland for Newport Pharmaceuticals Ltd, Swords, Co Dublin, Ireland =-see below for contact details. It is an older immune modulator or Th switcher and NK enhancer (Th2 to Th1 response) and has I believe been used with a moderate degree of success with CFIDS patients. It was licenced in 1971 for the treatment of cell mediated immune deficiencies associated with various viral infections. It has been shown to modulate CD4+ and CD8+ T cell functions. It was available in 26 countries last I looked but not the US. I believe that there may be clinical trials commencing in the US in the near future. In early 2004, after Kutapressin disappeared we trialled Immunovir with agreement from Dr Goldberg under or local Dr's direction - the medicine is cleared for use in Singapore but no longer available - we ordered directly from Dublin. After about 6 weeks, we saw little change, except that our son's liver enzyme responses rose very significantly so we stopped the trial. We reported this to the Dr in charge of clinical research at Newport Pharma in Ireland and she had not seen liver enzymes rise like this before, though she suggested that in combination with an antiviral and antifungal - this might tax the system somewhat, especially in children. Dr Goldberg was not about to drop his main defense lines - though. A lot more work has been done on the medicine since, though Dr Goldberg and Dr Galpin see this medicine of limited value in patients. If your interested see: http://www.anapsid.org/cnd/diagnosis/cheneyis.html This article talks abut balancing the TH1/TH2 response. http://www.anapsid.org/cnd/drugs/isoprinosine.html This is specifically about Immunovir. http://www.meao-cfs.on.ca/about_me/res_immunovir.shtml A summary about an early pilot study in CFS patients by Dr Byron Hyde The following is an abstract about results from a pilot study with Immonovir on CFS patients, again one of the researchers is Dr Byron Hyde from Canada. I do not have a link to the article though I can email a copy to you if you contact me offline - it was sent to me by Newport who are a sponsor. Journal of Chronic Fatigue Syndrome. Volume 11, Number 2 2003 ISSN:1057-3321 * Haworth Press Inc Clinical improvement in chronic fatigue syndrome is associated with enhanced natural killer cell-mediated cytotoxicity: the results of a pilot study with Isoprinosine* -Mitoma, F.[1], Turgonyi, E.[2], Kumar, A.[3], Lim, W.[4], Larocque, L.[5], Hyde, B.[6] Division of Virology, Children's Hospital of Eastern Ontario, The Nightingale Research Foundation, Canada and Newport Pharmaceuticals Ltd., Ireland. Abstract. Chronic fatigue syndrome is associated with systemic and cognitive symptoms and with several immune abnormalities. The clinical impact of Isoprino-sineR was evaluated in sixteen CFS patients, followed for 28 weeks in a single-blind, placebo controlled trial. Patients were also monitored for various immune parameters. Improvement based on clinical staging was observed in six of ten treated patients (60%). Clinically improved patients showed significantly enhanced natural killer (NK) cell activity, which correlated with the duration of IsoprinosineR treatment (p < 0.03). Treatment with IsoprinosineR resulted in significantly increased numbers of CD4+ T helper cells (p < 0.03). Treatment with IsoprinosineR for 12 weeks did not appreciably influence the in vitro production of IFN-g, IL-1a, IL-10 or IL-12. However, IL-12 was significantly increased at week 28 (p <0.02) in patients who improved after treatment with IsoprinosineR. These results suggest that taking IsoprinosineR may benefit a subgroup of patients with CFS, and this clinical improvement is associated with enhanced NK cell function and IL-12 levels. Further trials to evaluate the use of IsoprinosineR in the treatment of CFS patients are warranted. Keywords: chronic fatigue syndrome, Isoprinosine*, IFN-g, IL-12, IL-10, IL-2, Natural Killer Cells Supported by grants from Enterprise Ireland (130590/D). www.newport-pharma.com <http://www.newport-pharma.com/> Newport Pharmaceuticals Ltd Frans Maas House Swords Business Park Swords Co Dublin, Ireland TEL: + 353 1 890 3011 FAX: + 353 1 890 3016 Hope this helps _____ From: [mailto: ] On Behalf Of LINDA ANAGNOSTAKOS Sent: Saturday, September 16, 2006 8:26 PM Subject: Re: Imunovir/Nexavir Hi, Do know of anyone who has used either one of these meds. and if so have they seen any results good or bad yet? TIA, >From: Aut2BMiracles@ <mailto:Aut2BMiracles%40aol.com> aol.com >Reply-groups (DOT) <mailto:%40> com >groups (DOT) <mailto:%40> com >Subject: Re: Imunovir >Date: Fri, 15 Sep 2006 07:48:14 EDT > >Gaylen, > >I don't know much about Immunovir, but I have continued to look into >Nexavir. > >I did a google search and came across this link. It tells how to connect >with the FDA's site and shows the status of Nexavir's FDA approval. It is >currently on the FDA's site and shown as an approved medication. My >understanding >is that it's approval was grandfathered in the same way as Kutapressin. >Good >news! > > >http://www.nexcopha <http://www.nexcopharma.com/fda-info.htm> rma.com/fda-info.htm > > >Sharon :-) > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 18, 2006 Report Share Posted September 18, 2006 , I do know several people who have tried Nexavir (not any who have tried the Imunovir). I have heard mostly positive results, but I don't think it works for everyone. If you are interested in hearing from people who have tried it, I would consider joining the kutapressin list on . Kutapressin was the name of Nexavir under it's old manufacturer. Sharon Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 18, 2006 Report Share Posted September 18, 2006 What are these meds for? Are they to strengthen the immune system? Kristy Re: Imunovir/Nexavir , I do know several people who have tried Nexavir (not any who have tried the Imunovir). I have heard mostly positive results, but I don't think it works for everyone. If you are interested in hearing from people who have tried it, I would consider joining the kutapressin list on . Kutapressin was the name of Nexavir under it's old manufacturer. Sharon Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 19, 2006 Report Share Posted September 19, 2006 Kristy, Nexavir is a pretty strong antiviral, but from what I understand it does have a bit of an immune boost also. The downside is that it is an injection. Some parents don't like to do that. I read on the kutapressin list that it can be compounded into a topical cream also though. Many of the people on the list are using it to treat Chronic Fatigue as well. Sharon Quote Link to comment Share on other sites More sharing options...
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