Re: I'm new: anyone have good results with caronosine?

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>

Thanks Sue for the additional info...I have found some research that

warns of some negative effects from long term usage. If you have

time, check out this link and let me know what you think. (scroll

down to " Pangborn: opposing view

http://www.geocities.com/fishstep/carnosine.html

> 1

> Hi rdklynx1 --from Sue,

> Yes... we have for our ADHD / focus/etc....

> and I will also send another report form a family with a 5 year old

> child with ASD. next.

> While Carnosine is most known for it's antiglycation.. " turning

old cells into new cells "

> associated with anti-aging benefits... it has numerous

neurological benefits as

> Dr. Chez found for children with ASD in his double blind studies

summarized below.

> Note the benefits for SEIZURES as well.

>

> I find that the LW Yage Carnosine patch helps me with my memory,

focus, getting things done

> and motivation...not to mention it's wonderful rejuvenation of

cells due to getting

> rid of metabolic wastes !...

> I also have a study showing Carnosine killed all 7 types of cancer

found in a Petri dish.

> so if anyone wants that study let me know....at st@... ...

>

> See BELOW for summaries on Carnosine studies..

> by another product.(but keep in mind oral supplementation is not as

effective as the LW patches in most cases)

> More info is at the very bottom of this post regarding the NON

trandermal LW Yage Carnosine patches.

>

> L - C A R N O S I N E

>

> What is Carnosine?

>

> The naturally-occurring amino acid is found within the human body,

a by-product of

> proteins digested within the body. The deep frontal part of the

brain (entorhinal

> cortex) is believed to be a site where carnosine tends to

accumulate. It may

> interact with zinc in that area, as well as having effects on GABA,

a brain

> neurotransmitter, which by a complex chemical reaction forms homo-

carnosine.

>

> What Studies Have Been Done with Carnosine?

> Rat and animal studies have been done with carnosine looking

at " neuroprotection. "

> These investigations aimed to examine protective action since

carnosine may be

> protective of muscle and nervefunction. There have been no studies

that have shown

> any evidence of toxicity or teratogenicity in animals where

carnosine has been

> studied. Few scientifically-validated human studies have been

conducted, however,

> and most of the information one finds about carnosine's claims are

of the quality

> found on the internet. Claims have been made for generic

carnosine/carnosine

> formulations aiding in combating a range of maladies from

Alzheimer's to body

> building.

>

> Why Carnosine, then?

> Recent MRI studies by Petroff and colleagues (2001) examining

levels of brain

> chemistry showed a relationship between homo-carnosine and GABA in

temporal

> lobe and generalized myoclonic epilepsies. These authors described

homo-carnosine

> levels that may correlate with SEIZURE CONTROL even when GABA

response is defective

> in human studies. Dr. Chez was intrigued by the results of this

study, and thus began

> a study in June, 2001 that aimed to test if supplementing carnosine

orally could

> enhance seizure protection in children who were already on

anticonvulsants and who

> had recurrent SEIZURES despite being on standard drug therapy. He

hypothesized that

> the addition of carnosine could DECREASE seizure frequency and so

began an

> open-label study of carnosine which he acquired via an industrial

chemical company.

>

> The Open-Label Study

> A total of 75 children, who had " failed " multiple

antiepilepticmedications in an effort

> to stop their seizures (including steroids and the Ketogenic diet)

with histories of

> partial or generalized EPILEPSY entered the open-label study. The

majority had

> fronto-temporal lobe seizures, or generalized epilepsy.

Approximately 25% had EEGs to

> directly compare before and after starting the carnosine. Many

patients had

> reductions in seizure frequency, but without EEG correlation. Two

sisters with

> hypsarrythmia/Lennox-Gastaut variant both showed dramatic

improvements

> in EEG amplitude, spike frequency, and background activity. In

three other patients with

> primary or secondary generalized spike and wave patterns or Lennox-

Gastaut type

> patterns, EEG amplitude and spike frequency improved with carnosine

in dosages

> of 800-2,000 mg. per day. Dosage was titrated upward depending upon

bodyweight.

> No side effects were reported.Unexpectedly, parental diaries showed

a pattern of

> comments related to gains in cognitive domains including language,

alertness,

> energy levels, and even gross motor ability. Dr. Chez was motivated

by such reports

> in addition to comments from other professionals that worked

simultaneously with

> the children (e.g., speech therapists) who, unaware that children

were on the new

> supplement, spontaneously stated that individual children were

showing incremental

> gains not previously seen. Expressive language was described as

more fluent, eye

> contact more frequent, and interest in the environment was more

prominent.

> Dr. Chez thought that this supplement could be of benefit to

children with autism or

> PDD and so began to give it to children with such diagnoses in an

open-label trial.

> Indeed, parents reported benefits in their children after as few as

2 weeks, in the

> areas of socialization, expressive language, alertness level,

energy level, adaptation

> to change, and curiously, gross motor planning.

>

> The Double-Blind Study

> Because of the remarkable cognitive improvements in language,

speech production

> and school performance as well as social alertness, Dr. Chez felt

it important to

> study the effect of the supplement in children with Autistic

Spectrum Disorders.

> Children were included in this study if they had histories of

abnormal EEG, and

> had previously responded to cognitive-enhancing dementia

medications (as part of a

> controlled study at the office) or to anti-convulsants. A double-

blind placebo

> controlled study with carnosine was begun. Children were randomly

placed on either

> active carnosine or placebo. Expressive and receptive language

measures, two

> autism rating scales, and parent rating analog scales were

administered at the start

> and completion of the study. Results of this study indicated

clinically meaningful

> changes in many aspects of autistic features, and also showed that

the carnosine

> supplement improved children's expressive and receptive language

significantly. This

> is the only dietary supplement to date studied in a double-blind

fashion in autism.

>

> Who Benefits and What are the Side Effects?

> The majority of children with either epilepsy or autism treated in

open label studies

> by Dr. Chez benefited from carnosine supplementation. Dr.Chez

estimates that

> approximately 10% of children who have been on the carnosine

supplement have

> had reports of no improvement. A very small percentage (less than

5% of children

> with epilepsy or autistic spectrum disorders) have shown increased

physical

> hyperactivity or verbal hyperactivity, but we are unable to

ascertain if these reports

> are directly related to the carnosine supplement. No sleep

disturbances were

> reported as a result of carnosine therapy even in dosages up to

3,000 mg. a day.

> No abdominal side effects, skin rashes, or any changes in

anticonvulsant blood

> levels, liver functions or hematological studies. No patients had

any urinary changes

> or bowel habit changes from the carnosine.Many children on the

autistic spectrum

> were reported to increase their range of food choices with an

improved range of

> appetite.Responses have been seen in generalized epilepsies, focal

seizure

> disorders, autism, PDD, and head injury to date. Because of its

effect on entorhinal

> cortex, improvements in Alzheimer's disease or other frontal lobe

encephalopathy may

> be possible. Any syndrome that involves apraxia or expressive

language delay may

> benefit from this. Concurrent studies are currently being run or

planned in areas of

> attention disorder, Tourette's syndrome, and various learning

disability syndromes of

> the nonverbal type.

>

>

> PS.....from Sue.....

> One type of LW Yage patches give a continuous boost of Carnosine

for a full 12 -+++hour

> time period since they activate the body to produce more of it's

OWN carnosine.

>

> ( I say ONE type..since YAGE patches come in sets of either

> 1. One pkg. of Carnosine booster..PLUS one pkg. of GSH boosters

> OR

> 2. TWO pks. of the GSH =( Glutathione boosters ) alone.)

>

> They are NON transdermal...and work using resonant energy (similar

to radio waves)

> to achieve this effect...when activated by the bodies INFRARED heat

even up to 6 inches away from the body....so they will work ON

CLOTHING as well as the skin.

>

> There are many studies done on the effectiveness of the various

patches

> shown on the website... www.lifewave.com/jhennings. and a short 8

minute video

> called The Lifewave Report that explains the technology.

> 4.

> I'm new: anyone have good results with carnosine?

> Posted by: " rdklynx1 " rdklynx1@... rdklynx1

> Mon Mar 10, 2008 5:25 pm (PDT)

> I am considering adding carnosine to my 4 1/2 yr. son's biomeds.

Has

> anyone had good results with this? I've researched that this is a

small

> natural protein that has had great results acting as a

> neurotransmitter. A double blind study done at Autism and

Epilepsy

> Specialty Services in Lake Bluff, Il. resulted in an increase in

verbal

> abilities with 30 out of 31 children with autism.

>

> Check out the website for more details:

>

> http://autismcoach.com/Carnosine%20Study.htm

>

>

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