Re: Opinion on recent posts/Lori

[Guest guest]

Not Kristy, but are you saying all B-12 disorders can be corrected in that way?

It might be a different issue with the child if the mother has a b-12 metabolism

disorder, as my friend does.

Dr. Goldberg makes sense to me in saying that the metabolic issue is secondary

to the autoimmune issue (therefore correct the problem where it originates), but

there could be kids that have inherited a parent's b-12 disorder too. This is

the real reason my friend's child responded so amazingly to b-12 shots (in her

opinion). He does well on hydroxy or methyl, so he probably does not have a

methylation defect per se, but an inherited b-12 disorder. He is going through

genetic tests to verify. He might not be the only child out there like this.

I saw a re-run on discovery health recently (mystery diagnosis) about a boy

who was assumed to have autism with seizures. His mom was learning about the

GF/CF diet, when she wondered if he might have inherited her celiac's disease.

He tested positive, they removed gluten only, did nothing else and he became

completely normal. The doctors said he was hard to diagnose as he had an

unusual presentation of celiacs (it made him appear autistic w/seizures). My

friend's son seems to be this way with his b-12 problems, but this is certainly

not the case with every child with autism taking b-12.

-

Lori <lbharris@...> wrote:

Wouldn't excessively high B12 on your child's bloodwork be

contra-indicated

to giving them more? When does it become toxic? Isn't it better to get

their bodies healthy so that they can absorb it properly thorough food and

basic OTC supplementation?

Just by humble opinion and one from a Mom who's kid's was sky high and is

now normal.

Lori

RE: Re: Opinion on recent posts/Rhoda

Rhoda,

I, too, need B12 shots, but the B12 shots I get are different than the

ones

Dr. Neubrander uses. I am definitely interested in more info on this, if

you

have any.

My son, too, tested off-the-charts high for B12.

Kristy

Rhoda Boyd <rboyd@...> wrote:

For example, information from this group makes me wonder if B-12 plays a

larger role with my son than others. His levels were through the roof at

two

years old and have never been tested again. I have a B-12 absorption

problem

and have to get shots so maybe there is something to that. I need to

research all of that a little more.

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[Guest guest]

But .maybe the B12 disorder that seems to be inherited is simply a

symptom of an inherited immune disorder - from parent to child? Thqat

immune dysfunction is likely as Dr Goldberg often states have a genetic

component!

_____

From: [mailto: ] On Behalf Of Rob or

Sunseri

Sent: Sunday, June 11, 2006 6:34 AM

Subject: RE: Re: Opinion on recent posts/Lori

Not Kristy, but are you saying all B-12 disorders can be corrected in that

way? It might be a different issue with the child if the mother has a b-12

metabolism disorder, as my friend does.

Dr. Goldberg makes sense to me in saying that the metabolic issue is

secondary to the autoimmune issue (therefore correct the problem where it

originates), but there could be kids that have inherited a parent's b-12

disorder too. This is the real reason my friend's child responded so

amazingly to b-12 shots (in her opinion). He does well on hydroxy or methyl,

so he probably does not have a methylation defect per se, but an inherited

b-12 disorder. He is going through genetic tests to verify. He might not be

the only child out there like this.

I saw a re-run on discovery health recently (mystery diagnosis) about a boy

who was assumed to have autism with seizures. His mom was learning about the

GF/CF diet, when she wondered if he might have inherited her celiac's

disease. He tested positive, they removed gluten only, did nothing else and

he became completely normal. The doctors said he was hard to diagnose as he

had an unusual presentation of celiacs (it made him appear autistic

w/seizures). My friend's son seems to be this way with his b-12 problems,

but this is certainly not the case with every child with autism taking b-12.

-

Lori <lbharriscogeco (DOT) <mailto:lbharris%40cogeco.ca> ca> wrote:

Wouldn't excessively high B12 on your child's bloodwork be contra-indicated

to giving them more? When does it become toxic? Isn't it better to get

their bodies healthy so that they can absorb it properly thorough food and

basic OTC supplementation?

Just by humble opinion and one from a Mom who's kid's was sky high and is

now normal.

Lori

RE: Re: Opinion on recent posts/Rhoda

Rhoda,

I, too, need B12 shots, but the B12 shots I get are different than the

ones

Dr. Neubrander uses. I am definitely interested in more info on this, if

you

have any.

My son, too, tested off-the-charts high for B12.

Kristy

Rhoda Boyd <rboydcyberus (DOT) <mailto:rboyd%40cyberus.ca> ca> wrote:

For example, information from this group makes me wonder if B-12 plays a

larger role with my son than others. His levels were through the roof at

two

years old and have never been tested again. I have a B-12 absorption

problem

and have to get shots so maybe there is something to that. I need to

research all of that a little more.

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[Guest guest]

Hi, all.

I just want to make some comments on the B12 issue. As you may

know, the methylation cycle uses B12 in the methylcobalamin form.

Many of the children with autism as well as (it is beginning to

appear) many of the adults with chronic fatigue syndrome are either

unable to convert other forms of B12 to methylcobalamin, or they are

unable to recycle methylcobalamin to use it again, as is normal. If

they are unable to convert, they may supplement B12 and test high in

it, but they are not able to utilize it as methylcobalamin. The

same can happen with folate, which can show up as high Figlu in a

urinary organic acids test, indicating that even though there is a

lot of folate in the body, it cannot be converted to the active

forms for use. Whethter these things occur depends on the

particular genetic polymorphisms that the person has.

Glutathione is required to convert other forms of B12 to

methylcobalamin, and many people with autism and CFS are depleted in

glutathione.

The enzymes methionine synthase and methionine synthase reductase

need to be operating properly in order to utilize and recycle

methylcobalamin. Many of the people with autism or CFS have

polymorphisms in these enzymes.

In these cases, supplementing with methylcobalamin (subcutaneous is

best, because it is released more slowly into the blood) has helped

quite a few. Depending on the particular combination of

polymorphisms that is present in the person, they may need other

supplements as well, such as active forms of folate or

trimethylglycine or others. This is the basis for the major gains

in treatment that have been made by the DAN! project and by Dr. Amy

Yasko. I think there are still unresolved issues, but this approach

really has helped many.

I realize that the approach involves supporting the immune

system, and the immune system is certainly involved in these

disorders, but I think it is important to consider that this may be

a downstream effect in the pathogenesis in many cases. The reason

is that both glutathione depletion and a block in the folate

metabolism will cause immune dysfunction, particularly in the cell-

mediated part of the immune response, which is necessary to fight

viruses, intracellular bacteria and yeasts.

Glutathione depletion has been shown by a lot of published research

to interfere with proper T cell function. A correct folate

metabolism is necessary to make new DNA, RNA and thymidine, which

are needed to make new cells, as normally occurs when the

lymphocytes proliferate (clone themselves) in response to a viral

(or other) infection. The methylation cycle and the folate

metabolism are linked, so that when there is a block in the

methylation cycle, there is also a block in the folate metabolism.

I would encourage people to consider these possibilities.

Rich

> For example, information from this group makes me wonder if B-12

plays a

> larger role with my son than others. His levels were through the

roof at

> two

> years old and have never been tested again. I have a B-12

absorption

> problem

> and have to get shots so maybe there is something to that. I need

to

> research all of that a little more.

>

> We Made Changes

> Your email is all new.

> Learn More

>

> Share Feedback

>

> Recent Activity

>

> 6

> New Members

>

> Visit Your Group

>