Re-post IVIG research

May 21, 2006

Repost w/comments from Cheryl regarding the choices

between IVIG and IMGG....

Our children don't have the type of immune defects

that cause life

threatening illnesses. In those cases the benefits

outweigh the risks.

For our children the known risks (no matter how small)

and the unknown risks

(emerging pathogens) don't outweigh any potential

benefit.

Cheryl

------------------------------------------------------------------

Thromb Res 2002 Oct 31;107 Suppl:S39 Related Articles,

Links

Virus safety of human blood, plasma, and derived

products.

Guertler L.

Friedrich Loeffler Institute for Medical Microbiology,

University of

Greifswald, Luther Strasse 6, D-17489,

Greifswald, Germany

The reconstitution of blood and its components is

hampered by factors of

compatibility, availability, and the risk of

transmission of infectious

diseases. Protozoal agents such as plasmodium malariae

and trypanosoma cruzi

are only regionally relevant. Bacterial transmissions

are easy to prevent

and treat. Antibody, antigen, and nucleic acid

screening have been

implemented to prevent transmission of blood-borne

viruses.

Transfusion-relevant viruses include hepatitis B and C

virus (HBV and HCV),

human immunodeficiency virus (HIV), human T leukemia

virus (HTLV-I), and in

certain circumstances, parvovirus B19, hepatitis A

virus (HAV), and

cytomegalovirus (CMV).Of great concern is the possible

transmission of prion

protein causing transmissible spongiform

encephalopathy. Of future interest

will be whether other viruses such as Nipah and Hendra

virus are blood-borne

and whether viruses such as TT, SEN, and GBV-C are

involved in diseases or

their progression, while not causing hepatitis.

PMID: 12379292 [PubMed - in process]

Br J Haematol 2002 Sep;118(4):1187-9

Life-threatening human parvovirus B19 infection

transmitted by intravenous

immune globulin.

Hayakawa F, Imada K, Towatari M, Saito H.

First Department of Internal Medicine, Nagoya

University School of Medicine,

Nagoya, and Toyota Medical Corporation Kariya General

Hospital, Kariya,

Japan.

Infection of human parvovirus B19 (B19) is usually a

self-limiting febrile

illness, but can sometimes be life-threatening under

certain circumstances,

such as aplastic crisis in patients with haemolytic

anaemia, hydrops fetalis

in pregnant women and fulminant hepatitis. B19 canbe

transmitted through

respiratory secretions, transplacentally and by

transfusion of blood or

blood products. In the present case, administration of

intravenous immune

globulin (i.v.Ig) transmitted B19 infection and

consequently caused pure red

cell aplasia and aggravation of hepatitis to fulminant

hepatitis. Our case

may raise important questions as to the safety of

i.v.Ig and possible

contamination by B19.

PMID: 12199806 [PubMed - in process]

Transfus Med 2002 Aug;12(4):275-83 Related Articles,

Links

Nucleic acid testing for emerging viral infections.

Allain JP, I, Sauleda S.

Division of Transfusion Medicine, Department of

Haematology, East Anglia

Blood Centre, Cambridge, UK. jpa1000@...

The development of new technologies leads to the

discovery of new viruses.

For each of these new infectious agents, relevance to

transfusion, including

transmissibility by transfusion, pathogenicity,

prevalence in blood donors,

persistence and the availability of screening assays

needs to be assessed.

Since 1995, one virus and a new family of viruses have

been identified. GB

virus-C/hepatitis G virus (GBV-C/HGV), a flavi virus

with some homology with

and epidemiological features of HCV, is not related to

post-transfusion

hepatitis but seems to positively interfere with human

immunodeficiency

virus replication. Human circoviruses include TT virus

(TTV) and SEN-V. Both

are highly variable, constituting a large family of

distantly related

viruses. They appear ubiquitous, infecting humans very

early in life and are

largely persistent. No clinical symptoms or

pathogenicity is associated with

TTV, but SEN-V might be associated with some non-A-E

post-transfusion

hepatitis. Parvovirus B19 has been known for many

years, but its

transmission to recipients of plasma derivatives

despite viral inactivation

raised the issue of screening plasma pools by nucleic

acid testing. Most

fractionators quantify B19 DNA in plasma pools to

ensure a viral load of

<10(4) IU mL-1.

PMID: 12220257 [PubMed - in process]

J Virol Methods 2002 Jun;104(1):59-67 Related

Articles, Links

Real-time PCR methods for independent quantitation of

TTV and TLMV.

Moen EM, Sleboda J, Grinde B.

Department of Virology, National Institute of Public

Health, P.O. Box 4404

Nydalen, N-0403, Oslo, Norway.

There is considerable interest in the possible

clinical effects of the human

circoviruses TT virus (TTV) and TTV-like mini virus

(TLMV). Most people

appear to have at least one of these viruses

replicating actively in their

bodies, thus mere correlation of the presence of virus

and disease states

are probably less informative than a quantitative

analysis of viraemia.

Real-time PCR based methods, with either SYBR Green or

TaqMan probe,

designed to quantitate selectively TTV and TLMV are

described. The suggested

TaqMan-based protocols were suitable for quantitation

of viruses in the

range of 10(2)-10(9) copies/ml of sample; and proved,

by sequencing of PCR

products, to be specific for each of the two viruses.

PMID: 12020793 [PubMed - indexed for MEDLINE]

Boneva RS, Grindon AJ, Orton SL, Switzer WM, Shanmugam

V, Hussain AI,

Bhullar VB, Chamberland ME, Heneine W, Folks TM,

Chapman LE. Related

Articles, Links

Simian foamy virus infection in a blood donor.

Transfusion. 2002 Jul;42(7):886-91.

PMID: 12375661 [PubMed - indexed for MEDLINE]

3: JI, Rud EW, Pilon RG, JM, Switzer WM,

Sandstrom PA. Related

Articles, Links

Cross-species retroviral transmission from macaques to

human beings.

Lancet. 2002 Aug 3;360(9330):387-8.

PMID: 12241782 [PubMed - indexed for MEDLINE]

: Herwaldt BL, Neitzel DF, Gorlin JB, Jensen KA,

EH, Peglow WR,

Slemenda SB, Won KY, Nace EK, Pieniazek NJ, M.

Sign In

Re-post IVIG research

Recommended Posts

Guest guest

Link to comment

Share on other sites

Join the conversation

Activity