Mar 21 07-maternal antibrain antibodies in asd

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2007 Mar;21(3):351-7. Epub 2006 Oct 6.Click here to read

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Maternal antibrain antibodies in autism.

* Zimmerman AW

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_AbstractPlus & term=%22Zimmerman+AW%22%5BAuthor%5D>,

* Connors SL

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_AbstractPlus & term=%22Connors+SL%22%5BAuthor%5D>,

* Matteson KJ

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_AbstractPlus & term=%22Matteson+KJ%22%5BAuthor%5D>,

* Lee LC

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_AbstractPlus & term=%22Lee+LC%22%5BAuthor%5D>,

* Singer HS

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_AbstractPlus & term=%22Singer+HS%22%5BAuthor%5D>,

* Castaneda JA

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_AbstractPlus & term=%22Castaneda+JA%22%5BAuthor%5D>,

* Pearce DA

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_AbstractPlus & term=%22Pearce+DA%22%5BAuthor%5D>.

Department of Neurology and Developmental Medicine, Kennedy Krieger

Institute, 707 North Broadway, Baltimore, MD 21205, USA.

zimmerman@...

Autism is a neurodevelopmental disorder of prenatal onset that is

behaviorally defined. There is increasing evidence for systemic and

neuroimmune mechanisms in children with autism. Although genetic

factors are important, atypical prenatal maternal immune responses

may also be linked to the pathogenesis of autism. We tested serum

reactivity in 11 mothers and their autistic children, maternal

controls, and several groups of control children, to prenatal,

postnatal, and adult rat brain proteins, by immunoblotting. Similar

patterns of reactivity to prenatal (gestational day 18), but not

postnatal (day 8) or adult rat brain proteins were identified in

autistic children, their mothers, and children with other

neurodevelopmental disorders, and differed from mothers of normal

children, normal siblings of children with autism and normal child

controls. Specific patterns of antibody reactivity were present in

sera from the autism mothers, from 2 to 18 years after the birth of

their affected children and were unrelated to birth order.

Immunoblotting using specific antigens for myelin basic protein

(MBP) and glial acidic fibrillary protein (GFAP) suggests that these

proteins were not targets of the maternal antibodies. The

identification of specific serum antibodies in mothers of children

with autism that recognize prenatally expressed brain antigens

suggests that these autoantibodies could cross the placenta and

alter fetal brain development.

PMID: 17029701 [PubMed - in process]