sorry for my brain fog

[Guest guest]

Dear Rhoda

I totally apologize to you but the amount of fake people we have on this

list are ridiculous and we are now putting steps in place where anyone can

still join the list but we will know who is and isn’t a patient. I

literally took a fall, have a concussion (not myself) and haven’t viewed the

list lately, I saw your post and pulled the wrong IP again I apologize.

Truth be told I feel sorry for your son. Canada is the only place that has

recently published reports, saying there is no immune connection (even

though the rest of the research world, keeps supporting the immune

connection, even if they don’t want to). To deny the importance of low NK

cells in your child is very sad (low NK cells, linked to low NK cell

activity > chronic viral activation, etc.) . In research we do at

university levels, when you sub-define the immune system down to cytokines

and other things that are way above my head, but I do know that they are

learning these virus’s do damage to the brain and are probably changing and

replicating in our DNA as I type (I’m sure you have read “ The Virus

Within”). This is not meant to scare anyone but just a harsh reality. I’m,

sorry if you have had a bad experience and you are of course entitled to

your opinion. However what the doctor’s have told you is like before they

treated ulcers with antibiotics before it was totally proved it was a

bacteria causing the problem. The work Dr. Goldberg is doing at research

levels, proves the damage and is clearly shown on Spect scans. We have

scans showing an active viral process. So please ask these doctors if they

will guarantee you your son won’t have seizures and scalloping of his brain

in years to come from non treatment. Most of the drugs Dr. Goldberg uses

are neuro-protective and stop or at least slows down the viral process in

the brain. (It may have been wise to speak with Dr. Goldberg re the

specifics of your child before making a decision like this. Many times

there can seem to be a “honeymoon” off therapy, then progress slows or

stops, and if there has been a virus present, it proceeds in SlOW, likely

destructive manner).

Here are some links on low NK cells if you like or for others, there are

MANY more if you wish to do a pub med search . . .

Again sorry for my brain fog

Elyse Goldberg

: HYPERLINK " javascript:AL_get(this,%20'jour',%20'J%20Virol.'); " J Virol.

2007 Feb 7; [Epub ahead of print]HYPERLINK

" http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?itool=AbstractPlus-def & P

rId=3051 & uid=17287257 & db=pubmed & url=http://jvi.asm.org/cgi/pmidlookup?view=l

ong & pmid=17287257 " \nClick here to read HYPERLINK

" javascript:PopUpMenu2_Set(Menu17287257); " Links

Induction of Natural Killer Cell Responses by Ectromelia Virus Controls

Infection.

· HYPERLINK

" http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pu

bmed_AbstractPlus & term=%22+AK%22%5BAuthor%5D " AK,

· HYPERLINK

" http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pu

bmed_AbstractPlus & term=%22+S%22%5BAuthor%5D " S,

· HYPERLINK

" http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pu

bmed_AbstractPlus & term=%22Yokoyama+WM%22%5BAuthor%5D " Yokoyama WM,

· HYPERLINK

" http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pu

bmed_AbstractPlus & term=%22Corbett+JA%22%5BAuthor%5D " Corbett JA,

· HYPERLINK

" http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pu

bmed_AbstractPlus & term=%22Buller+RM%22%5BAuthor%5D " Buller RM.

Departments of Molecular Microbiology and Immunology and; Biochemistry and

Molecular Biology, Saint Louis University Health Sciences Center, 1402 South

Grand Blvd., Saint Louis, MO 63104, USA; Medical Institute,

Rheumatology Division, Department of Medicine, Washington University School

of Medicine, St. Louis, MO 63110, USA.

Natural killer (NK) cells play a pivotal role in the innate immune response

to viral infections, particularly murine cytomegalovirus (MCMV) and human

herpesviruses. In poxvirus infections the role of NK cells is less clear. We

examined disease progression in C57BL/6 mice after removal of NK cells by

both antibody depletion and genetic means. We found that NK cells were

crucial for survival and the early control of virus replication in spleen

and to a lesser extent in liver in C57BL/6 mice. Studies of various knockout

mice suggested that gammadelta T cells and NKT cells are not important in

the C57BL/6 mousepox model and CD4(+) and CD8(+) T cells do not exhibit

antiviral activity at 6 days post-infection when the absence of NK cells has

a profound effect on virus titers in spleen and liver. NK cell cytotoxicity

and/or IFN-gamma secretion likely mediated the antiviral effect needed to

control virus infectivity in target organs. Studies of the effects of ECTV

infection on NK cells demonstrated that NK cells proliferate within target

tissues (spleen and liver) and become activated following a low dose footpad

infection, although the mechanism of activation appears distinct from the

ligand-dependent activation observed with MCMV. NK cell IFN-gamma secretion

was detected by intracellular cytokine staining (ICS) transiently at 32-72

hours p.i. in the lymph node suggesting a role in establishing a TH1

response. These results confirm a crucial role for NK cells in controlling

an ectromelia virus infection.

PMID: 17287257 [PubMed - as supplied by publisher]