Elevated cytokine levels in children with autism spectrum disorder.

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Molloy CA, Morrow AL, Meinzen-Derr J, Schleifer K, Dienger K,

Manning->>P, Altaye M, Wills-Karp M.>>Neuroimmunol. 2005 Dec 14; [Epub

ahead of print]>>Center for Epidemiology and Biostatistics, Cincinnati

Children's Hospital>>Medical Center, 3333 Burnet Avenue, MLC 5041, Cincinnati,

OH 45229-3039, United>>States; Division of Developmental and Behavioral

Pediatrics, Cincinnati>>Children's Hospital Medical Center, 3333 Burnet Avenue,

MLC 4002, Cincinnati, OH>>45229-3039, United States; Department of Pediatrics,

University of Cincinnati>>College of Medicine, United States.>> >>This study

compared production of IL-2, IFN-gamma, IL-4, IL-13, IL-5 and IL-10>>in

peripheral blood mononuclear cells from 20 children with autism

spectrum>>disorder to those from matched controls. Levels of all Th2 cytokines

were>>significantly higher in cases after incubation in media alone, but

the>>IFN-gamma/IL-13 ratio was not significantly different between cases

and>>controls. Cases had significantly higher IL-13/IL-10 and IFN-gamma/IL-10

than>>controls. Conclusion: Children with ASD had increased activation of both

Th2 and>>Th1 arms of the adaptive immune response, with a Th2 predominance, and

without>>the compensatory increase in the regulatory cytokine IL-10.>> >>PMID:

16360218 [PubMed - as supplied by publisher]>> >>