Guest guest Posted April 20, 2007 Report Share Posted April 20, 2007 Immune Dysregulation in a Cohort of Children with Autism Spectrum Disorders Faber, Carolyn Kobelak, Caminos. Medicine, The Childrens Institute, Pittsburgh, PA. BACKGROUND: Children with autism spectrum disorders demonstrate increased frequency of immunologic abnormalities including signs of elevated innate and humoral immunity. T and B cell subsets provide a method of assessing T helper (CD4) and suppressor (CD8) cell ratio, which influences B cell antibody production. Elevated CD4/CD8 ratio can lead to excessive B cell antibody production, increasing the creation of cross-reactive antibodies that can mediate autoimmune and inflammatory reactions. About 10% of children are sensitive to gluten, as demonstrated by increased antigliadin IgG and/or IgA antibody production. Only 1% of children demonstrate elevated tissue transglutaminase (tTGA), suggesting the presence of celiac disease. OBJECTIVE: This study sought to determine the frequency and pattern of immunological abnormalities in a cohort of children with autism spectrum disorders, to search for a set of immunologic markers that help define this population. DESIGN/METHODS: A retrospective review of data from 47 children (35 male, 12 female, mean age 5.71, SD 3.4 ) with Autistic Disorder, PDD.NOS, and Aspergers Disorder diagnosed by structured interview, rating scales, and play observation was performed. T and B cell subset, serum immunoglobulin, antigliadin antibody, and tTGA data, obtained after the diagnostic visit, was reviewed. RESULTS: CD4 number was elevated in 22 children (47 %), while CD4% was elevated in 14 children (30 %). CD8 number was decreased in 19 children (40 %) while CD8% was low in 42 children (89 %). Elevated CD4/CD8 ratio was found in 24 children (51 %). Total B cell (CD19) number was elevated in 24 (51 %) of the children while total T cell (CD3) number was increased in 20 (43 %) of the children. Abnormalities of NK cell % or number were present in 38 (81 %) of the children. Three, one, and 10 children displayed elevations of serum IgG, IgA, and IgM respectively. Twenty-five children (53 %) demonstrated antigliadin IgG elevations, while three (6 %) had increased antigliadin IgA. Elevated tTGA was not seen in the cohort. CONCLUSIONS: Children with autism spectrum disorders frequently display high CD4/CD8 ratios, supporting the presence of hyperreactivity of the humoral immune system. Low CD8% may be a sensitive marker of immune dysregulation in this population. Innate immune system (NK cell) dysfunction and gluten sensitivity, without evidence of celiac disease, are commonly present. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2007 Report Share Posted April 24, 2007 Thank you for posting this. It is great to see this data coming from yet another source. Anyone else ever feel like we should hold a conference like they did in the movie " Lorenzo's Oil " and get all of these folks in the same room? --- In , Doris and Steve <sjsmith@...> wrote: > > Immune Dysregulation in a Cohort of Children with Autism Spectrum Disorders > > Faber, Carolyn Kobelak, Caminos. Medicine, The Childrens > Institute, Pittsburgh, PA. > > BACKGROUND: Children with autism spectrum disorders demonstrate > increased frequency of immunologic abnormalities including signs of > elevated innate and humoral immunity. T and B cell subsets provide a > method of assessing T helper (CD4) and suppressor (CD8) cell ratio, > which influences B cell antibody production. Elevated CD4/CD8 ratio can > lead to excessive B cell antibody production, increasing the creation of > cross-reactive antibodies that can mediate autoimmune and inflammatory > reactions. About 10% of children are sensitive to gluten, as > demonstrated by increased antigliadin IgG and/or IgA antibody > production. Only 1% of children demonstrate elevated tissue > transglutaminase (tTGA), suggesting the presence of celiac disease. > OBJECTIVE: This study sought to determine the frequency and pattern of > immunological abnormalities in a cohort of children with autism spectrum > disorders, to search for a set of immunologic markers that help define > this population. > DESIGN/METHODS: A retrospective review of data from 47 children (35 > male, 12 female, mean age 5.71, SD 3.4 ) with Autistic Disorder, > PDD.NOS, and Aspergers Disorder diagnosed by structured interview, > rating scales, and play observation was performed. T and B cell subset, > serum immunoglobulin, antigliadin antibody, and tTGA data, obtained > after the diagnostic visit, was reviewed. > RESULTS: CD4 number was elevated in 22 children (47 %), while CD4% was > elevated in 14 children (30 %). CD8 number was decreased in 19 children > (40 %) while CD8% was low in 42 children (89 %). Elevated CD4/CD8 ratio > was found in 24 children (51 %). Total B cell (CD19) number was elevated > in 24 (51 %) of the children while total T cell (CD3) number was > increased in 20 (43 %) of the children. Abnormalities of NK cell % or > number were present in 38 (81 %) of the children. Three, one, and 10 > children displayed elevations of serum IgG, IgA, and IgM respectively. > Twenty-five children (53 %) demonstrated antigliadin IgG elevations, > while three (6 %) had increased antigliadin IgA. Elevated tTGA was not > seen in the cohort. > CONCLUSIONS: Children with autism spectrum disorders frequently display > high CD4/CD8 ratios, supporting the presence of hyperreactivity of the > humoral immune system. Low CD8% may be a sensitive marker of immune > dysregulation in this population. Innate immune system (NK cell) > dysfunction and gluten sensitivity, without evidence of celiac disease, > are commonly present. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2007 Report Share Posted April 24, 2007 Maybe I need to watch that movie. I have told my husband that we need to lock Dr. Pardo in a room with Dr. G (sorry Dr. G) for a couple of days (we'd give you two some really good food). I can think of several others I'd like to send in there, too. We'd let them out when they had a plan. Oh, and we'd have to put someone rich and powerful in there... lots of funding and ways to make it happen. Maybe we could lock them in Trader Joe's... with some air mattresses and nice sleeping bags. They'd have lots of food, a microwave... hey... I could spend a few days in there having samples! Caroline > From: meljackmom <meljackmom@...> > Reply-< > > Date: Tue, 24 Apr 2007 13:31:17 +0000 > < > > Subject: Re: Immune Dys in ASD > > Anyone else ever feel like we should hold a conference like they did > in the movie " Lorenzo's Oil " and get all of these folks in the same > room? > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2007 Report Share Posted April 24, 2007 The only problem is Dr. G doesn't cook , in our 25 yr relationship he has never made me a meal. He say its because he loves me and doesn't want to kill me . so please add a chef to the plan Elyse Goldberg No virus found in this outgoing message. Checked by AVG Free Edition. Version: 7.5.463 / Virus Database: 269.5.10/774 - Release Date: 4/23/2007 5:26 PM Quote Link to comment Share on other sites More sharing options...
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