RE: Testosterone & autoimmune encephalitis/Need Help with Article Referenced

[Guest guest]

Am I reading this article below to indicate that testosterone was

administered to rats which in turn elevated cortisol which lessened the

risk of autoimmune encephalitis? Thus, the testosterone is protective??

I had always assumed that heightened levels of testosterone was probably

a negative thing in correlation with ASD due to the fact that it is a

predominately male disorder. However, if testosterone is protective in

the context of this article, then theoretically, wouldn't it be

contraindicated to give Lupron to an ASD child with such a neurological

autoimmune disease/dysfunction? Is this right or am I reading it

wrong??? I want to understand this.

Re: Testosterone & autoimmune enceph.

What is the drug Lupron?? Also, I haven't seen the earlier thread on

this conversation, but I'm sure you are referring to the effect on

anti-myelin basic protein and relation to previous studies on autism.

Beverly

On Jun 10, 2006, at 1:39 AM, Rob or Sunseri wrote:

> Interesting since the drug Lupron is being used off-label for/and

> reportedly helps some boys with autism.

>

> -

>

>

> Doris and Steve <sjsmithcablespeed (DOT)

<mailto:sjsmith%40cablespeed.com> com> wrote:

> ssages in this topic (3)

>

> 5.

>

> testosterone in rats and the development of autoimmune

> encephalomyel

> <http://us.lrd. <http://us.lrd./> /

> _ylc=X3oDMTJycGxqZ3V2BF9TAzk3MzU5NzE1BGdycElkAzE5NTc3MjQEZ3Jwc3BJZAMxN

> jAwMDYxNjE2BG1zZ0lkAzY2NTkyBHNlYwNkbXNnBHNsawN2bXNnBHN0aW1lAzExNDk4MDQ

> wOTk-;_ylg=1/SIG=11lmvfgn3/**http%3a///group/abmd/

> message/66592>

>

> Posted by: " natasa778 " nenodalmaholidays (DOT)

<mailto:neno%40dalmaholidays.co.uk> co.uk

> <mailto:nenodalmaholidays (DOT) <mailto:neno%40dalmaholidays.co.uk>

co.uk?Subject=Re:%20testosterone%20in%

> 20rats%20and%20the%20development%20of%20autoimmune%20encephalomyel>

> natasa778 <http://profiles. <natasa778>

/natasa778>

>

> Thu Jun 8, 2006 3:35 am (PST)

>

> Neuroimmunomodulation. 2005;12(4):246-54.

>

> Oral testosterone in male rats and the development of experimental

> autoimmune encephalomyelitis.

>

> Maccio DR, Calfa G, Roth GA. Departamento de Quimica Biologica y

> Centro de Investigaciones en Quimica Biologica de Cordoba, Facultad de

> Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba,

> Argentina.

>

> OBJECTIVES: Considering that sex steroids can influence the immune

> system, we studied the development of experimental autoimmune

> encephalomyelitis (EAE), a T-cell-mediated autoimmune disease of the

> central nervous system, and the concomitant cell-mediated immunity in

> gonadally intact and gonadectomized male Wistar rats given

> testosterone

> supplementation. METHODS/RESULTS: Sham-operated rats and surgically

> castrated animals were orally self-administered with vehicle or

> testosterone added in the water bottle for 20 days before EAE

> induction.

> The androgenic effect of oral testosterone self-administration was

> evidenced by changes in body weight, and in the weights of

> androgen-dependent testes and seminal vesicles. Testosterone

> administration reduced the incidence of clinical signs of EAE in

> sham-operated animals and reversed the clinical symptoms of the

> disease

> associated with castrated EAE animals. The clinical signs observed in

> the different groups correlated with changes in delayed-type

> hypersensitivity and mononuclear cell-proliferative responses to the

> encephalitogenic myelin basic protein. Moreover, testosterone but not

> cholesterol supplementation in vitro suppressed the proliferative

> response of mononuclear cells to myelin basic protein suggesting that

> testosterone may affect specific immune functions through direct

> actions

> on immune cells. Finally, self-administration of testosterone induced

> also elevated corticosterone levels that in sham-operated rats

> correlated with the low incidence of the disease and in gonadectomized

> animals could be involved in the remission of clinical symptoms of

> EAE.

> CONCLUSIONS: These results suggest that orally self-administered

> testosterone can modulate specific cellular immune responses and serum

> corticosterone levels leading to changes in the development of EAE.

> Copyright 2005 S. Karger AG, Basel.

>

> PMID: 15990455 [PubMed - indexed for MEDLINE

>

>

[Guest guest]

My pediatrician said that Nizoral has an effect on

increasing testosterone levels and that this was a

probably benefit to " ASD " ...

--- " K. Fischer " <elfischer@...> wrote:

> Am I reading this article below to indicate that

> testosterone was

> administered to rats which in turn elevated cortisol

> which lessened the

> risk of autoimmune encephalitis? Thus, the

> testosterone is protective??

> I had always assumed that heightened levels of

> testosterone was probably

> a negative thing in correlation with ASD due to the

> fact that it is a

> predominately male disorder. However, if

> testosterone is protective in

> the context of this article, then theoretically,

> wouldn't it be

> contraindicated to give Lupron to an ASD child with

> such a neurological

> autoimmune disease/dysfunction? Is this right or am

> I reading it

> wrong??? I want to understand this.

>

>

>

> Re: Testosterone & autoimmune

> enceph.

>

> What is the drug Lupron?? Also, I haven't seen the

> earlier thread on

> this conversation, but I'm sure you are referring to

> the effect on

> anti-myelin basic protein and relation to previous

> studies on autism.

>

> Beverly

>

> On Jun 10, 2006, at 1:39 AM, Rob or Sunseri

> wrote:

>

> > Interesting since the drug Lupron is being used

> off-label for/and

> > reportedly helps some boys with autism.

> >

> > -

> >

> >

> > Doris and Steve <sjsmithcablespeed (DOT)

> <mailto:sjsmith%40cablespeed.com> com> wrote:

> > ssages in this topic (3)

> >

> > 5.

> >

> > testosterone in rats and the development of

> autoimmune

> > encephalomyel

> > <http://us.lrd. <http://us.lrd./>

> /

> >

>

_ylc=X3oDMTJycGxqZ3V2BF9TAzk3MzU5NzE1BGdycElkAzE5NTc3MjQEZ3Jwc3BJZAMxN

>

> >

>

jAwMDYxNjE2BG1zZ0lkAzY2NTkyBHNlYwNkbXNnBHNsawN2bXNnBHN0aW1lAzExNDk4MDQ

>

> >

>

wOTk-;_ylg=1/SIG=11lmvfgn3/**http%3a///group/abmd/

>

> > message/66592>

> >

> > Posted by: " natasa778 " nenodalmaholidays (DOT)

> <mailto:neno%40dalmaholidays.co.uk> co.uk

> > <mailto:nenodalmaholidays (DOT)

> <mailto:neno%40dalmaholidays.co.uk>

> co.uk?Subject=Re:%20testosterone%20in%

> >

>

20rats%20and%20the%20development%20of%20autoimmune%20encephalomyel>

> > natasa778 <http://profiles.

> <natasa778>

> /natasa778>

> >

> > Thu Jun 8, 2006 3:35 am (PST)

> >

> > Neuroimmunomodulation. 2005;12(4):246-54.

> >

> > Oral testosterone in male rats and the development

> of experimental

> > autoimmune encephalomyelitis.

> >

> > Maccio DR, Calfa G, Roth GA. Departamento de

> Quimica Biologica y

> > Centro de Investigaciones en Quimica Biologica de

> Cordoba, Facultad de

> > Ciencias Quimicas, Universidad Nacional de

> Cordoba, Cordoba,

> > Argentina.

> >

> > OBJECTIVES: Considering that sex steroids can

> influence the immune

> > system, we studied the development of experimental

> autoimmune

> > encephalomyelitis (EAE), a T-cell-mediated

> autoimmune disease of the

> > central nervous system, and the concomitant

> cell-mediated immunity in

> > gonadally intact and gonadectomized male Wistar

> rats given

> > testosterone

> > supplementation. METHODS/RESULTS: Sham-operated

> rats and surgically

> > castrated animals were orally self-administered

> with vehicle or

> > testosterone added in the water bottle for 20 days

> before EAE

> > induction.

> > The androgenic effect of oral testosterone

> self-administration was

> > evidenced by changes in body weight, and in the

> weights of

> > androgen-dependent testes and seminal vesicles.

> Testosterone

> > administration reduced the incidence of clinical

> signs of EAE in

> > sham-operated animals and reversed the clinical

> symptoms of the

> > disease

> > associated with castrated EAE animals. The

> clinical signs observed in

> > the different groups correlated with changes in

> delayed-type

> > hypersensitivity and mononuclear

> cell-proliferative responses to the

> > encephalitogenic myelin basic protein. Moreover,

> testosterone but not

> > cholesterol supplementation in vitro suppressed

> the proliferative

> > response of mononuclear cells to myelin basic

> protein suggesting that

> > testosterone may affect specific immune functions

> through direct

> > actions

> > on immune cells. Finally, self-administration of

> testosterone induced

> > also elevated corticosterone levels that in

> sham-operated rats

> > correlated with the low incidence of the disease

> and in gonadectomized

> > animals could be involved in the remission of

> clinical symptoms of

> > EAE.

> > CONCLUSIONS: These results suggest that orally

> self-administered

> > testosterone can modulate specific cellular immune

> responses and serum

> > corticosterone levels leading to changes in the

> development of EAE.

> > Copyright 2005 S. Karger AG, Basel.

> >

> > PMID: 15990455 [PubMed - indexed for MEDLINE

> >

> > [Non-text portions of this message have been

> removed]

> >

> > __________________________________________________

> >