Re: Genetic explanations for neuro-immune issues

[Guest guest]

Hi Gaylan

I haven't posted in a while but your post intrigued me. My son has the

same abnormals in his labs that your son does. We thought it had to do with

his Chiari because after his decompression surgeries , when his brain once

again had normal CSF and blood flow, these issues resolved.

However, their back now, and it's once again a mystery to me. Our Dr. is

blaming these abnormal labs on the drug Diamox, which he needs to lower his

intracranial pressure, due to pseudo-tumor cerebri. I'm skeptical though, I

believe that it's neuro-immune related.

Maybe I'll look into Amy Yasko's testing? What can be done, if anything,

with the results? Is this for research only or is there a treatment

protocol to follow?

Thank you for any information and take good care,

>From: Googahly@...

>Reply-

> , Autism-Immune ,

>neuroendocrineimmune

>Subject: Genetic explanations for neuro-immune issues

>Date: Sun, 13 May 2007 13:53:37 EDT

>

>Hi Everyone,

>

>As I've been researching the issues shown in my son's Nutrigenomic Test

>results (the genetic test that explores the mutations Dr. Amy Yasko is

>researching), I've been intrigued that many of these could start to explain

>the problems

>that are seen in patients with and neuroimmune problems. I am also

>intrigued by how these explanations fit so well into what we have found

>through

>trial and error through the years. One in particular, is that my son's

>testing

>showed positive for the mutation in both COMT gene areas which affects the

>enzyme that breaks down dopamine in the body. According to the

>explaination

>detailed in a book and DVD of a Yasko lecture, this issue can lead to too

>much

>dopamine in the body and a greater need for seratonin, as well as problems

>when

>alot of supplements are used.

>

>Other mutations that he tested positive for could explain some of the

>strange

>results we've seen through the years on lab tests (ie: low CO2, elevated

>EOS

>no matter what we do, low creatinine/high BUN, etc.) I'm hoping that as I

>delve further, we may also find an answer to his extremely low natural

>killer

>cells.

>

>This research is very new and constantly evolving so I don't think it gives

>us a clear picture of what's going on yet but I think it could be helpful

>as we

>try to figure out how to help our kids. I'd be very interested to hear

>some

>thoughts on how some of these findings would or wouldn't apply to an

>overall

> or neuroimmune protocol. Any thoughts?

>Gaylen

>

>

>

>

>************************************** See what's free at

>http://www.aol.com.

>

>

>

[Guest guest]

When you say genetic, I am thinking it implies passed along traits from the

mother or father. Are you referring to this or some mutation on the gene caused

by environmental factors, such as toxic exposure? We are undoubtably sure our

son's illness was caused by vaccinations (he was typical with language and all

until his year and a half round of shots). My impression is that most feel that

our children's illness is due to vaccine injury, so please, can further

explanation be given to the use of " genetic " ?

>From: LINDA A <lsa5885@...>

>Date: 2007/05/14 Mon AM 08:02:01 CDT

>

>Subject: RE: Genetic explanations for neuro-immune issues

>

>Hi Gaylan

>

>I haven't posted in a while but your post intrigued me. My son has the

>same abnormals in his labs that your son does. We thought it had to do with

>his Chiari because after his decompression surgeries , when his brain once

>again had normal CSF and blood flow, these issues resolved.

>

>However, their back now, and it's once again a mystery to me. Our Dr. is

>blaming these abnormal labs on the drug Diamox, which he needs to lower his

>intracranial pressure, due to pseudo-tumor cerebri. I'm skeptical though, I

>believe that it's neuro-immune related.

>

>Maybe I'll look into Amy Yasko's testing? What can be done, if anything,

>with the results? Is this for research only or is there a treatment

>protocol to follow?

>

>Thank you for any information and take good care,

>

>

>

>>From: Googahly@...

>>Reply-

>> , Autism-Immune ,

>>neuroendocrineimmune

>>Subject: Genetic explanations for neuro-immune issues

>>Date: Sun, 13 May 2007 13:53:37 EDT

>>

>>Hi Everyone,

>>

>>As I've been researching the issues shown in my son's Nutrigenomic Test

>>results (the genetic test that explores the mutations Dr. Amy Yasko is

>>researching), I've been intrigued that many of these could start to explain

>>the problems

>>that are seen in patients with and neuroimmune problems. I am also

>>intrigued by how these explanations fit so well into what we have found

>>through

>>trial and error through the years. One in particular, is that my son's

>>testing

>>showed positive for the mutation in both COMT gene areas which affects the

>>enzyme that breaks down dopamine in the body. According to the

>>explaination

>>detailed in a book and DVD of a Yasko lecture, this issue can lead to too

>>much

>>dopamine in the body and a greater need for seratonin, as well as problems

>>when

>>alot of supplements are used.

>>

>>Other mutations that he tested positive for could explain some of the

>>strange

>>results we've seen through the years on lab tests (ie: low CO2, elevated

>>EOS

>>no matter what we do, low creatinine/high BUN, etc.) I'm hoping that as I

>>delve further, we may also find an answer to his extremely low natural

>>killer

>>cells.

>>

>>This research is very new and constantly evolving so I don't think it gives

>>us a clear picture of what's going on yet but I think it could be helpful

>>as we

>>try to figure out how to help our kids. I'd be very interested to hear

>>some

>>thoughts on how some of these findings would or wouldn't apply to an

>>overall

>> or neuroimmune protocol. Any thoughts?

>>Gaylen

>>

>>

>>

>>

>>************************************** See what's free at

>>http://www.aol.com.

>>

>>

>>

[Guest guest]

I am just trying to understand her work right now but from what I gather, the

genetic mutations are mostly what is passed down through families. How they

are expressed can be changed with various environmental conditions though and

there is certainly science to suggest that genes themselves can be changed

over time due to various environmental factors.

Dr. Yasko does offer various treatments to compensate for the genetic

mutations but it is extremely individualized and complicated because the doctor

needs

to take into consideration all of the various combinations of problems. From

what I've been able to understand so far, the 37 gene sites that the test

checks all contribute to four different issues: increased homocysteine,

decreased methylation, decreased BH4 and elevated ammonia. People can have a

variety

of mixtures of these mutations which leads to various disease states.

Her treatments involve a combination of rx medications, supplements, dietary

changes and probably some other stuff I haven't learned about yet. The one

area I've read the most about is the COMT mutation, which my son has on both of

the " problem " locations they investigate but not on the site that can mitigate

the problem a bit. Since this leads to a build-up of too much dopamine, the

recommendation is to limit foods containing high dopamine (ie: bananas,

avocados, etc) and increase foods that containing high levels of seratonin.

Interestingly, we had already removed all of the foods on the high-dopamine list

because we saw that my son did not do as well when he ate these foods. I'm not

sure yet if she recommends a SSRI in this case, but I would think it wouldn't

be a big leap to think it would be helpful.

Another interesting thing from the DVD lecture I watched yesterday, was her

assertion that creatinine helps the body battle and excrete viruses. One of

the pathways they examine with this test, is the urea cycle and creatinine.

Several sites on the NOS and CBS genes are supposedly involved in this. My

son's

test showed positive for the NOS mutation. If I'm understanding this

properly, this mutation makes it more difficult for the body to creatinine and

urea

properly. Then ammonia builds up in the body and the body starts " burning

arginine " in an attempt to create creatinine. One of the many signs of ammonia

build-up that she mentions is arm flapping and body tensing (something we've

seen with my son over the years, especially before we started ). This

really

got my attention because my son has had chronically low creatinine levels for

years until the past few months. A year ago, we added an arginine supplement

to help boost growth hormone levels due to very delayed growth. (NOTE: This

was on the advise of an endocrinologist and not at all related to the

protocol which is extremely limited in which supplements are recommended.)

After adding the arginine, we noticed a definite improvement not only in growth

and muscle-building but also in overall functioning. I found this to be very

interesting since other reports say arginine is contraindicated for people with

viral problems. I have to explore this much further but I wonder if this was

inadvertingly treating this NOS problem.

While I am cautious about jumping into other treatments and supplements since

the protocol has helped my son a great deal, I think the information

provided by the Nutrigenomic test could possibly be very helpful in guiding the

process someday and would love to see Dr. Goldberg or others with a better

understanding of neuroimmune issues look into it and give their comments.

Gaylen

************************************** See what's free at http://www.aol.com.

[Guest guest]

Dr. Yasko cannot prescribe medications so what treatments is she offering? Kathy

Re: Genetic explanations for neuro-immune issues

I am just trying to understand her work right now but from what I gather, the

genetic mutations are mostly what is passed down through families. How they

are expressed can be changed with various environmental conditions though and

there is certainly science to suggest that genes themselves can be changed

over time due to various environmental factors.

Dr. Yasko does offer various treatments to compensate for the genetic

mutations but it is extremely individualized and complicated because the doctor

needs

to take into consideration all of the various combinations of problems. From

what I've been able to understand so far, the 37 gene sites that the test

checks all contribute to four different issues: increased homocysteine,

decreased methylation, decreased BH4 and elevated ammonia. People can have a

variety

of mixtures of these mutations which leads to various disease states.

Her treatments involve a combination of rx medications, supplements, dietary

changes and probably some other stuff I haven't learned about yet. The one

area I've read the most about is the COMT mutation, which my son has on both of

the " problem " locations they investigate but not on the site that can mitigate

the problem a bit. Since this leads to a build-up of too much dopamine, the

recommendation is to limit foods containing high dopamine (ie: bananas,

avocados, etc) and increase foods that containing high levels of seratonin.

Interestingly, we had already removed all of the foods on the high-dopamine list

because we saw that my son did not do as well when he ate these foods. I'm not

sure yet if she recommends a SSRI in this case, but I would think it wouldn't

be a big leap to think it would be helpful.

Another interesting thing from the DVD lecture I watched yesterday, was her

assertion that creatinine helps the body battle and excrete viruses. One of

the pathways they examine with this test, is the urea cycle and creatinine.

Several sites on the NOS and CBS genes are supposedly involved in this. My son's

test showed positive for the NOS mutation. If I'm understanding this

properly, this mutation makes it more difficult for the body to creatinine and

urea

properly. Then ammonia builds up in the body and the body starts " burning

arginine " in an attempt to create creatinine. One of the many signs of ammonia

build-up that she mentions is arm flapping and body tensing (something we've

seen with my son over the years, especially before we started ). This really

got my attention because my son has had chronically low creatinine levels for

years until the past few months. A year ago, we added an arginine supplement

to help boost growth hormone levels due to very delayed growth. (NOTE: This

was on the advise of an endocrinologist and not at all related to the

protocol which is extremely limited in which supplements are recommended.)

After adding the arginine, we noticed a definite improvement not only in growth

and muscle-building but also in overall functioning. I found this to be very

interesting since other reports say arginine is contraindicated for people with

viral problems. I have to explore this much further but I wonder if this was

inadvertingly treating this NOS problem.

While I am cautious about jumping into other treatments and supplements since

the protocol has helped my son a great deal, I think the information

provided by the Nutrigenomic test could possibly be very helpful in guiding the

process someday and would love to see Dr. Goldberg or others with a better

understanding of neuroimmune issues look into it and give their comments.

Gaylen

************************************** See what's free at http://www.aol.com.

[Guest guest]

In a message dated 5/15/2007 4:18:02 PM Central Daylight Time,

JOSKAT95@... writes:

<<Dr. Yasko cannot prescribe medications so what treatments is she offering?

>>

I haven't gotten very far into reading about the actual treatments yet. At

this point, I'm more interested in the research into the specific genetic

mutations and the problems they cause in the body. Early on, I had read a

little

bit about her using a lot of supplements and some sort of homeopathic stuff.

For that reason, I hestitated quite awhile in really looking into her work.

However, the genetic test really intrigued me and after talking to several

parents who had run the test just to know about breakdowns in their kids'

systems,

I thought it might be helpful.

I have read/heard in the lectures about three meds so far -- one that reduces

ammonia in the body, progesterone that's used for the ACE deletion and one

currently being used in China for one of the mutations that my son doesn't have.

So far, I've come across mention of dietary changes for two of the areas that

showed to be problems on my son's test -- limiting dopamine-increasing foods

and bumping up seratonin-increasing foods; and limiting protein when ammonia

is building up too fast in the body. He was already doing the first without

knowing why because we had seen a clear pattern of difficulty with most of the

foods on the high-dopamine list and found he did better when eating many on the

seratonin list. Over the last week, he's been a bit stimmy and body tensing

with no obvious cause. This can be a sign of high ammonia for those with the

NOS and/or CBS mutations, according to the Dr. Yasko lecture I watched. We're

experimenting with temporarily lowering his meat intake and bumping up fruits

and veggies. He is doing much better today but it could be just a

coincidence.

I believe there is a section on her website where she details treatments for

various mutations that you can read if you're interested in knowing how she

treats the problems. I'm not sure how much we'll get into the non-dietary

treatments with my son. I mostly ran the test to be aware of the mutations in

making decisions for him. Then again, once I understand them fully, I may feel

comfortable venturing into some of the treatments that would address some

specific areas that haven't budged. Since these mutations have been studied by

other researchers, it will also be interesting to see how others are addressing

them.

Gaylen

************************************** See what's free at http://www.aol.com.